PARP inhibitor

[Annie1373]

Just wondering if Rucaparib or Olaparib is used by oncologists for BRCA mutated advanced prostate cancer patients?

[LearnAll]

YES. Both Rucaparib and Olaparib (PARP inhibitors) were approved by FDA recently for metastatic prostate cancer which has BRCA mutation.

[Tall_Allen]

Yes. You can read about them here:prostatecancer.news/2019/10...

[Goldberg]

Hi I am Brca2. I have Mets to my bone and lymph glands. I started on Olaparib last August. My PSA had gone from 9 to 70 within 3months. My PSA is now at 5. My scans showno tumor changes. I don’t know how long it will last but I appreciate it as long as it lasts. The only problem is the expense. It cost 14,700/month my copay is 12,000/yr. It puts a big bite on my retirement funds.

[HopingForTheBest1 in reply to Goldberg]

Astra Zeneca has a financial assistance program to help with your copay. It is based on income.

[Hidden]

I have BRCA and ATM mutations and will begin Rucaparib in February. It is via a clinical trial that has you go through 4 sessions of Docetaxel and Carboplatin to assist with getting things 'ready' for the PARP inhibitor. Supposedly this is how it has been used in successful Ovarian cancer cases.

[Danish-patient in reply to Hidden]

What is the name of that trial?

[Hidden in reply to Danish-patient]

clinicaltrials.gov/ct/searc...

[Rsdutcher7]

and if anybody knows...do you have to fail at Chemo or just ADT before having access?