Burnett1948-Chemo Continuation

[Burnett1948]

After my Low Volume metastasised PC was diagnosed in about August 2020 I started Hormone then right on 3 months later in November in had one shot of Chemo. This treatment stopped because I got a abscess (because of incontenence) on my testicles (put on antibiotics). After reading what Tall-Allen and other say about combinations (stampede trial) giving you more time I am seeing my Medical Oncologist to see if I can continue; after this 6 week break, the 5 shot course of chemo. But just now Exercise has me feeling good. I know adding chemo is what I should do for more life but I know it will make me physically weak for about 12 to 15 weeks given that my doctor allows me to continue. I am 72 and I thought I was fit. Is the extra 15 months worth starting chemo again? Advice please?

[Tall_Allen]

Chemo increases QOL. How you feel now is not how you will feel later.

[Burnett1948 in reply to Tall_Allen]

Thanks Tall-Allen

[Shooter1]

I'm 70 and 6 rounds of chemo weren't bad...I pushed through 9 cycles+xtandi. Horrible side effects from xtandi at full dose. Half dose OK.. I'd go for it... I feel good now and cancer in remission. Just my opinion from my experience. Good luck

[Hidden in reply to Shooter1]

🏜

[Burnett1948 in reply to Shooter1]

Thanks for the information about Xtanti.

[tango65]

There is not difference in overall survival when metastatic castration sensitive cancer is treated with abiraterone or docetaxel. You could continue your systemic therapy with ADT plus abiraterone and prednisone and postpone the chemotherapy.

pubmed.ncbi.nlm.nih.gov/295...

[Burnett1948 in reply to tango65]

tango65.Can you explain metastatic castration sensitive cancer please?

[tango65 in reply to Burnett1948]

Metastatic castration sensitive cancer is a cancer with lymph nodes mets outside the pelvis, or metastases in bones or in organs such as liver, lungs etc, which can be controlled by castration (testosterone below 50, preferable below 20). The castration stops the progression of the cancer and causes a drop in PSA (castration sensitive).

[shuckymesh62 in reply to tango65]

My Husband had castration surgery and was put on Zytiga. His testosterone dropped to almost zero but in 9 months his PSA level never dropped below 93. It started to rise sharply so they stopped the Zytiga and started him on Docetaxel. He went through two rounds of that and his platelets dropped to 38 so they stopped that and started radiation and his platelets dropped to 14. The prostate cancer has spread to his bone marrow. He is now on Hospice. He was originally diagnosed 18 months ago with a PSA of 1200 and profuse bone and lymph node involvement. Needless to say he has been in terrible bone and nerve pain the whole time.

[tango65 in reply to shuckymesh62]

Sorry to hear your husband's situation. Perhaps he has a form of prostate cancer that does not respond to castration , regular chemo or the new anti androgens, such as small cell PC or neuroendocrine PC. These cancers may respond for a while to chemo with platinum compounds associated with Jetvana with or without etoposide.

[j-o-h-n in reply to shuckymesh62]

Sorry to hear about you husband's condition. May God ease his pain.... Give him my regards...

j-o-h-n Tuesday 01/05/2021 10:12 PM EST

[shuckymesh62 in reply to j-o-h-n]

Thank you John.

[MateoBeach in reply to shuckymesh62]

So sorry to hear about his very rapid course and pain. Heart goes out to you two.

[tango65 in reply to Burnett1948]

Perhaps the opinions of a real expert in chemo for prostate cancer may be useful to you:

grandroundsinurology.com/dr...

[Burnett1948 in reply to tango65]

Thanks tango65. I’m hormone sensitive not hormone resistant which she said were the 75 per cent of successful PC suffers using both hormone & chemo.

[NevsMates]

If chemo is an option for you, you will never be younger. Go for it now. Best wishes

[Burnett1948 in reply to NevsMates]

Yes NevsMates. And I have been told Chemo is more effective early for PC. Thanks for your message.

[Burnett1948]

Nalakrats I am going to give it one more shot if the Oncologist lets me. If I can’t handle it I will give up. Thanks.