Low Dose Chemotherapy: Has anybody done... - Advanced Prostate...

Advanced Prostate Cancer

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Low Dose Chemotherapy

taylor123 profile image
12 Replies

Has anybody done low dose chemotherapy for their prostate cancer?

Some encouraging studies analysed below on it.

ncbi.nlm.nih.gov/pmc/articl...

12 Replies
Bill2005 profile image
Bill2005

I've used low dose cyclophoxphamide during my vacation from ADT about 10 years ago. Extended my vacation to almost 3 years. Other vacations from ADT without cyclophoxphamide only have lasted 10-12 months. I have currently added cyclophoxphamide to my current vacation from ADT. Very little to no side effects.

taylor123 profile image
taylor123 in reply to Bill2005

Very interesting. Did you previously use taxotere?

Bill2005 profile image
Bill2005 in reply to taylor123

Yes, I did the 6 doses of taxotere about 4 years ago.

taylor123 profile image
taylor123 in reply to Bill2005

So you did chemotherapy before ADT?

Bill2005 profile image
Bill2005 in reply to taylor123

Tried to do the chemo (taxotere) at the beginning 11 yrs ago but it was not accepted practice yet by insurance or oncologists. Only did ADT at the beginning. Did chemo with ADT after my second vacation from ADT after PSA was rising fast.

taylor123 profile image
taylor123

So Taxotere plus another ?

Tall_Allen profile image
Tall_Allen

Why are you considering low dose? Do you have some problem that precludes the full dose? Taxotere was tested at lower dose, but the 75 mg/mm2 dose every 3 weeks was found to be optimal.

tango65 profile image
tango65

It could offer some benefits and be well tolerated:

pubmed.ncbi.nlm.nih.gov/145...

thelancet.com/pdfs/journals...

gourd_dancer profile image
gourd_dancer

Taylor, unless you have serious co-mobility problems, i would not jack around with low dose infusions. Think chemo with Lupron and get as much as you can. It is better to take chemo when your body is strong and your tumor burden minimal.

I was very fortunate to be a guinea pig within weeks of mets at age 57 in 2004. My treatment in a six month clinical trial went way beyond SOC and I have not looked back......

Each course of chemotherapy lasts for 8 weeks. Patients were treated in weeks 1, 3, and 5 with doxorubicin 20 mg/m2 as a 24-hour intravenous infusion on the first day of every week in combination with ketoconazole 400 mg orally 3 times a day daily for 7 days. In weeks 2, 4, and 6, treatment consisted of paclitaxel 100 mg/m2 intravenously on the first day of every week in combination with estramustine 280 mg orally 3 times a day for 7 days. 30 mg of Prednisone everyday through the three courses of chemotherapy.

I admit that I am biased. Time to have a serious talk with your medical oncologist. I am willing to bet that the patients you are reading about have health problems,

GD

arete1105 profile image
arete1105

Dr Shallenberger uses this technique. It is called Insulin PotentiationnTherapy where he administers insulin first and then the chemo methoxrate.

MateoBeach profile image
MateoBeach

Not only is the concept to use lower doses but also to space the treatments over time to maintain a stable balance of susceptible and resistant cancer cell sub-populations to prolong a semi stable state of responsivity through Darwinian evolutionary dynamics. This is a form of “adaptive therapy” which is also the idea underlying BAT and also for adaptive cycling of abiraterone to prolong time to treatment failure.

nature.com/articles/s41467-...

“Brute Force” strategies including Max tolerated doses and high dose cycling most rapidly lead to predominance of the treatment resistant cells. Lower dose adaptive cycling strategies are being explored to surpass this inevitable limitation.

journals.plos.org/plosbiolo...

Union98 profile image
Union98

My husband had 6 doses of taxotere starting Feb 2017 when he was first diagnosed. He convinced the doctor to lower the dosage because at the time we couldn't understand why it was one dosage fits all and he didn't want to have to take Nulesta. His first dose was full strength, 2nd dose at 80% and the remaining doses at 90%. We were lucky to have an oncologist that would work with his wishes (even though he advised against it). Husband is undetectable at this point (ADT + Zytiga) working full time and still playing guitar in his cover band (not that they're gigging right now). Thanks for posting the study!

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