Olaparib (Lynparza) adds 4.4 months to survival among men who have the BRCA mutation

[Tall_Allen]

An update of the PROfound trial proved the benefit in radiographic progression-free survival translated into a significant overall survival benefit too. I updated my article:

prostatecancer.news/2019/10...

nejm.org/doi/10.1056/NEJMoa...

[SPEEDYX]

Thanks for the post....adds another targeted treatment into the mix...let's keep it coming!!!!!

[Bob10]

Why is 4.4 months a “significant survival “

[Tall_Allen in reply to Bob10]

It's statistically significant, but it is also meaningful. That is also about what all the other medicines (e.g., chemo, advanced hormonals, Provenge, and radiologicals) we have add in men who are metastatic and already castration resistant. It is a median, which means half the men do better, some men do a lot better. The men willing to try something untested in a randomized clinical trial may not be representative of the average patient in that setting.

[Bob10 in reply to Tall_Allen]

Ty

[tango65]

Link to the full paper:

sci-hub.st/https://www.nejm...

[Loves2golf]

Whenever you speak to a person who has lost a loved one, they often say, “if I could only have one more day to be with him/her”. Yet doctors say, “it only extends life 6 months. I’ll take those extra days!

[j-o-h-n]

4.4 months.... hmmm just enough time to get a gun license.......

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 09/23/2020 5:58 PM DST

[Hirsch in reply to j-o-h-n]

You live in New York. Gun license a good idea 👍

[j-o-h-n in reply to Hirsch]

If you need a gun permit in NYC you ain't gonna get one.... Gotta buy a discounted Saturday night special from a guy named Hector.......

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 4:41 PM DST

[SPEEDYX in reply to j-o-h-n]

We dont need any stinking license...or badges

[j-o-h-n in reply to SPEEDYX]

So you know Hector..... Hmmmmm

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 4:48 PM DST

[SPEEDYX in reply to j-o-h-n]

Si senor

[j-o-h-n in reply to SPEEDYX]

and Mucho Pistolas to you too........

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 6:13 PM DST

[SPEEDYX in reply to j-o-h-n]

Iam sure you will say hello to my little friend

[j-o-h-n in reply to SPEEDYX]

Hector the protector, inspector detector..........

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 6:19 PM DST

[SPEEDYX in reply to j-o-h-n]

Of an island

[j-o-h-n in reply to SPEEDYX]

Devil's

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 6:31 PM DST

[SPEEDYX in reply to j-o-h-n]

Papillon...great movie

[j-o-h-n in reply to SPEEDYX]

Good not great..... (held my interest however)

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 6:42 PM DST

[j-o-h-n in reply to j-o-h-n]

I'm not into current hollywood junk..... but we watched the movie.... "Marriage Story" which I think is a remake of Kramer vs Kramer but with curse words. I am not a prude by any stretch of the imagination but the movie sucked. They also threw in a knock against the Catholic church..... and I'm not religious but I do respect other people's beliefs even though they are not mine..... (soap box derby time) sorry.

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 6:50 PM DST

[Hidden in reply to j-o-h-n]

That’s what I would do with 4.4 months left!! Make sure I can’t be prosecuted!! Hahaha

[j-o-h-n in reply to Hidden]

Definitely D.A. will not prosecute you if know a guy named Hector....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 4:46 PM DST

[Fairwind]

My first month on Olaparib showed a big improvement in PSA numbers..But then it just stopped working just as quickly...It also has some rough side-effects, red blood cells and hemoglobin dropping to low numbers. (I needed a transfusion).. QOL became an issue when RBC's went below 2.6..All you want to do is sleep..

[immunity1]

Yes it is a good point Fairwind, Olaparib does tend to knock the erythrocytic cell pogenitor cells around and we do tend to overlook QOL outcomes with such treatments.