Interpreting DECIPHER test results? - Advanced Prostate...

Advanced Prostate Cancer

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Interpreting DECIPHER test results?

JPnSD profile image
14 Replies

I have just been informed my DECIPHER test results are in and they are mailing them to me. I don't have an appointment to review them with my doctor until the 24th. Can anyone suggest a good reference I should read about what these results might look like and questions I should have ready for my meeting? Not sure how versed my Dr. is on DECIPHER...as I had to fight tooth and nail to get it done and approved. She may need the references as well. Thank you.

14 Replies
tango65 profile image
tango65

decipherbio.com/wp-content/...

Tall_Allen profile image
Tall_Allen

Decipher includes info on how to interpret results.

DJBUNK profile image
DJBUNK

I had a Decipher test conducted last year after my surgery. The report was informative but I still had questions for which I have been unable to find answers.

First, the report gives an estimate of 5yr metastasis but does not define the term. Does it mean what is typically meant by prostate metastasis which is spread to bones, distant lymph nodes, other organs, etc? Or is spread to any node considered metastasis? In my case, the distinction is significant as I had a positive lymph node detected in the pathology. So does my decipher score refer to chances of further spread, or have I already crossed the threshold of metastasis? Or is that estimate meaningless in my case?

The other question relates to the risk category. Does it refer to a patient's risk relative to their previously determined risk category, or relative to the overall patient population?

tango65 profile image
tango65 in reply to DJBUNK

The cancer is considered metastatic when there are cancerous lesions in the lymph nodes outside the pelvis above the bifurcation of the aorta ( cancer is classified as M1a), in the bones anywhere,( cancer is classified as M1b) and in any organ (cancer is classified as M1c).

If your lymph nodes where found only in the pelvis your cancer is not considered metastatic, even when the cancer left the prostate and invaded the pelvic lymph nodes.

I believe the risk is related to the outcome of a population.

academic.oup.com/ndt/articl...

JRPnSD profile image
JRPnSD in reply to tango65

Thank you for this information. I had microscopic detection of PCA in 1 of 4 lymph nodes during by Prostatectomy....and people continually tell me I am Stage 4, despite vesicles being clear (Stage 3). I look forward to more information for giving me more perspective on where I stand in my journey.. Thank you.

tango65 profile image
tango65 in reply to JRPnSD

Best of luck on this journey!!

Jmr11820 profile image
Jmr11820

I had a DECIPHER as well. The results are fairly cut and dry. First they give you a score... low , intermediate, or high and also your likelihood of metastasis in 5 years and PCSM at 10 years. In my case I had a high score so we acted quickly for radiation rather than wait. I’m not aware of it being helpful in guiding any other treatment options.

bml123abc profile image
bml123abc in reply to Jmr11820

Jmr11820 - had the same experience. Received a high score (.92) and decided to get radiation right away. Still one year away from being clean for 5 years but so far so good.

Jmr11820 profile image
Jmr11820 in reply to bml123abc

Great! My .83 DECIPHER had a 33% chance of metastasis at 5 years. PSA prior to RT was . 03.

10 year PCSM 18%. Those numbers are etched into my brain.

Sound familiar?

bml123abc profile image
bml123abc in reply to Jmr11820

Yes, mine was 50% chance in 5 years. PSA was 6 before RT. Radiation did some damage but still worth it.

JRPnSD profile image
JRPnSD in reply to bml123abc

What was your PSA at the time you elected to have radiation?

Thanks

bml123abc profile image
bml123abc in reply to JRPnSD

it was undetectable right after surgery and stayed that way so far.

Jmr11820 profile image
Jmr11820

Congratulations on a successful treatment. DECIPHER has caused me a lot of stress. Do you mind sharing your 10 year PC mortality risk, according to DECIPHER?

JPnSD profile image
JPnSD in reply to Jmr11820

I have yet to receive it.

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