Aberaterone fast heartbeats

[Dondodoc]

Suffering from tachycardia cardiologist arranging angiogram. Spoke to consultant oncologist he immediately advised stopping aberaterone as of now ! This suggest aberaterone could be the cause?

Any ideas?

[Hidden]

My husband had horrible issues with full dose Zytiga. Shortness of Breath, heart skipping beats, dizzy, no balance, just about every issue. He too had all the tests for heart and everything came back fine. Oncologist suggested to stop Zytiga for three weeks to see if it was the medication. He felt great in about a week of stopping. Went back to the oncologist and he suggested cutting the dose in half. He did that and had no issues since. Still a little tired but livable. His PSA is still down to 0.05. Talk to your oncologist to see what he says. Good luck.

[Dondodoc in reply to Hidden]

Thank you

[j-o-h-n in reply to Dondodoc]

ZYTIGA® may cause serious side effects including:

High blood pressure (hypertension), low blood potassium levels (hypokalemia), fluid retention (edema), and irregular heartbeats. Your healthcare provider will check your blood pressure, do blood tests to check your potassium levels, and check for signs and symptoms of fluid retention every month.

Dizziness

Fast or irregular heartbeats

Feel faint or lightheaded

Headache

Confusion

Muscle weakness

Pain in your legs

Swelling in your legs or feet

Adrenal problems may happen if you stop taking prednisone, get an infection, or are under stress.

Liver problems. You may develop changes in liver function blood tests. Your healthcare provider will do blood tests to check your liver before treatment with ZYTIGA® and during treatment with ZYTIGA®. Liver failure may occur, which can lead to death. Tell your healthcare provider if you notice any of the following changes:

Yellowing of the skin or eyes

Darkening of the urine

Severe nausea or vomiting

Increased risk of bone fracture and death when ZYTIGA® and prednisone or prednisolone is used in combination with a type of radiation called radium Ra 223 dichloride. Tell your healthcare provider about any other treatments you are taking for prostate cancer

The most common side effects of ZYTIGA® include:

Feeling very tired

Joint pain

High blood pressure

Nausea

Swelling in your legs or feet

Low blood potassium levels

Hot flushes

Diarrhea

Vomiting

Infected nose, sinuses, or throat (cold)

Cough

Headache

Low red blood cells (anemia)

High blood cholesterol and triglycerides

High blood sugar levels

Certain other abnormal blood tests

ZYTIGA® may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

THESE ARE NOT ALL THE POSSIBLE SIDE EFFECTS OF ZYTIGA®.

FOR MORE INFORMATION, ASK YOUR HEALTHCARE PROVIDER OR PHARMACIST.

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/25/2020 1:52 PM DST

[GoBucks in reply to j-o-h-n]

But other than that......

[j-o-h-n in reply to Hidden]

** SEE SIDE EFFECTS LISTED ABOVE **

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 08/25/2020 1:53 PM DST

[Dondodoc in reply to j-o-h-n]

Thanks john

[timotur]

I was on Zytiga for five months and paused due to high BP, but stayed on Lupron, and PSA dropped anyway, so I didn't restart it. I was taking one pill with yogurt in the mornings as one full dose, and I could hear my ears start ringing almost immediately as the BP rose, from about 120 to 165 systolic. I also have occasional arrhythmia episodes, usually alleviated by lying down and drinking water, but there was one time on Zytiga I felt like I couldn't control it, and was close to going to ER.

Also, ADT in general with lower testosterone is associated with a prolonged QT interval, which is associated with cardiac arrhythmia, such as tachycardia. You may ask your Onc if a reduced dose is plausible, perhaps 2x 250mg/day.

Although much has been written about cardiovascular complications of ADT, one aspect that has not been investigated in a controlled setting is the potential effect of ADT on the cardiac conduction system. In an electrocardiogram (ECG), ventricular depolarization and repolarization are represented by the QRS complex and T wave, respectively. The QT interval duration corresponds to the total time from ventricular depolarization to repolarization. The QT interval corrected for heart rate (QTc) has been widely used in clinical settings to assess the risk of arrhythmias; indeed, prolongation in QTc is considered a risk factor for tachyarrhythmias and sudden cardiac death [14–16]. Previous studies have shown that gonadal steroids, testosterone in particular, modulate QTc. Indeed, the QTc duration is similar in newborn male and female babies [17], and no sex-related differences are observed before 10 years of age [18]. However, after puberty, the QTc significantly shortens in boys compared with girls, suggesting a direct effect of testosterone production of cardiac conduction system [19]. Studies in young men have shown that endogenous serum testosterone levels are inversely associated with QTc duration [20]. However, as men age, their QTc durations also increase, which is associated with age-related decline in serum testosterone levels [21, 22]. Clinical trials in community-dwelling men with low serum testosterone levels have also shown that testosterone administration is associated with shortening of QTc [23]. Hence, it is conceivable that profound androgen deficiency that occurs because of ADT slows ventricular repolarization and consequently leads to QTc prolongation, which, in turn, might predispose these patients to cardiac arrhythmias [24]. Indeed, a previous small, uncontrolled study had also observed prolongation of QTc with ADT [25].

ncbi.nlm.nih.gov/pmc/articl....

[Dondodoc in reply to timotur]

Thank you for that information

[GoBucks]

Make sure you are not getting too much caffeine. Also discuss taking a lower dose.

[Dondodoc in reply to GoBucks]

Thank you, oncologist has now stopped zytiga cardiologist has put me on digoxin and Apixaban. Wait and see I guess. Thanks for your reply

[Grumpyswife]

My husband experienced the same thing on full dose abiraterone with dexamethasone. He stopped the abiraterone and had a series of heart tests and wore a monitor.

In the mean time his PSA doubled over 90 days as all the heart tests were normal. Try to avoid that from happening to you as it will be a long road back and he may never get back to the previous level.

Luckily some thyroid blood tests indicated his heart/bp problems were related to hypothyroidism called Graves Disease and that medication (methimazole) was doubled. He also uses Atenolol to regulate the heartbeat and losartan for bp.