New MD Anderson Trial with Adenosine Receptor Antagonist and Small Molecule Inhibitor

[WhiteStrat]

My MO called today and asked if I am interested in an upcoming trial at MD Anderson. It involves the following drugs: 1) AB928, an adenosine receptor antagonist; 2) AB680, a small molecule inhibitor (CD73 inhibitor); and 3) Zimberelimab, an anti-PD-1.

I have done a little research on these drugs but haven't come up with much. Can someone explain what they are and how they may help with mCRPC? I have bone and lymph node mets.

[tango65]

These are links to info about these drugs provided by the National Cancer Institute:

cancer.gov/publications/dic...

cancer.gov/publications/dic...

cancer.gov/publications/dic...

It is about my pay grade, but it seems to me they are trying to boost the activity of T cells and also eliminate PD-1 in the T cells to facilitate identifying the cancer cells. You should discuss how big is the risk of developing autoimmune diseases when treated with the combination of these drugs.

abcam.com/cancer/cancer-imm...

[pjoshea13]

Basic info for the group:

Trial: clinicaltrials.gov/ct2/show...

AB928: arcusbio.com/etrumadenant/

Zimberelimab: arcusbio.com/zimberelimab/

ab680: arcusbio.com/ab680/

Adenosine receptor: en.wikipedia.org/wiki/Adeno...

Locations:

United States, California

The University of California, Los AngelesNot yet recruiting

Encino, California, United States, 91436

Contact: Site Coordinator 818-995-8044 [e-mail]

Principal Investigator: Sandy Liu, MD

The University of California, Irvine Medical CenterNot yet recruiting

Orange, California, United States, 92868

Contact: Site Coordinator 714-456-7005 [e-mail]

Principal Investigator: Edward Uchio, MD,FACS, CPI

The University of California, San FranciscoNot yet recruiting

San Francisco, California, United States, 94158

Contact: Site Coordinator 415-353-2051

Principal Investigator: Lawrence Fong, MD

The Oncology Institute of Hope & InnovationRecruiting

Whittier, California, United States, 90603

Contact: Kirsten Bettino 562-698-6888 [e-mail]

Principal Investigator: Merrill Shum, MD

United States, Connecticut

Yale School of MedicineNot yet recruiting

New Haven, Connecticut, United States, 06520

Contact: Site Coordinator 203-200-2328 [e-mail]

Principal Investigator: Joseph Kim, MD

United States, Florida

Florida Cancer Specialists NorthNot yet recruiting

Saint Petersburg, Florida, United States, 33705

Contact: Site Coordinator

Principal Investigator: Vijay Patel, MD

Florida Cancer Specialists SouthNot yet recruiting

Sarasota, Florida, United States, 34232

Contact: Site Coordinator 941-377-9993

Principal Investigator: Elizabeth Guancial, MD

Florida Cancer Specialists PanhandleNot yet recruiting

Tallahassee, Florida, United States, 32308

Contact: Site Coordinator 850-877-8166

Principal Investigator: Viralkumar Bhanderi, MD

Florida Cancer Specialists EastNot yet recruiting

West Palm Beach, Florida, United States, 33401

Contact: Site Coordinator 561-366-4100

Principal Investigator: Daniel Spitz, MD, FACP

United States, Illinois

Northwestern University Feinberg School of MedicineNot yet recruiting

Chicago, Illinois, United States, 60611

Contact: Site Coordinator 312-695-1102 [e-mail]

Principal Investigator: David VanderWeele, MD, PhD

United States, Maryland

Johns Hopkins UniversityNot yet recruiting

Baltimore, Maryland, United States, 21287

Contact: Site Coordinator 410-955-8964 [e-mail]

Principal Investigator: Michael Carducci, MD

United States, New York

New York University, Langone HealthNot yet recruiting

New York, New York, United States, 10016

Contact: Site Coordinator 212-731-6366

Principal Investigator: David Wise, MD, PhD

United States, Ohio

Cleveland ClinicNot yet recruiting

Cleveland, Ohio, United States, 44195

Contact: Site Cooordinator 866-223-8100

Principal Investigator: Moshe Ornstein, MD, MA

United States, Tennessee

Tennessee Oncology - ChattanoogaNot yet recruiting

Chattanooga, Tennessee, United States, 37404

Contact: Site Coordinator 423-698-1844

Principal Investigator: Edward Arrowsmith, MD

Tennessee Oncology - NashvilleNot yet recruiting

Nashville, Tennessee, United States, 37203

Contact: Site Coordinator 615-320-5090

Principal Investigator: Johanna Bendell, MD

United States, Texas

MD Anderson Cancer CenterRecruiting

Houston, Texas, United States, 77030

Contact: Site Coordinator

Principal Investigator: Sumit Subudhi, MD, PhD

United States, Washington

Medical Oncology Associates, PS (dba Summit Cancer Centers)Recruiting

Spokane, Washington, United States, 99208

Contact: Monika Chaudhry 855-786-6482 [e-mail]

Principal Investigator: Arvind Chaudhry, MD, PhD

United States, Wisconsin

University of Wisconsin Carbone Cancer CenterNot yet recruiting

Madison, Wisconsin, United States, 53792

Contact: Site Coordinator 608-265-1700 [e-mail]

Principal Investigator: Hamid Emamekhoo, MD

Canada, Alberta

Tom Baker Cancer CenterNot yet recruiting

Calgary, Alberta, Canada, T2N 4N2

Contact: Site Coordinator 403-521-3723

Principal Investigator: Steven Yip, MD, MSc

Canada, New Brunswick

The Moncton HospitalNot yet recruiting

Moncton, New Brunswick, Canada, E1C 6Z8

Contact: Site Coordinator 506-857-5111 [e-mail]

Principal Investigator: Mahmoud Abdelsalam, MD, CCFP

Canada, Ontario

Juravinski Cancer CenterNot yet recruiting

Hamilton, Ontario, Canada, L8V5C2

Contact: Site Coordinator 905-387-9495 ext 64417 [e-mail]

Principal Investigator: Sebastien Hotte, MD

Canada, Quebec

Centre hospitalier de l'Université de Montréal (CHUM) Centre de RechercheNot yet recruiting

Montréal, Quebec, Canada, H2X 3E4

Contact: Site Coordinator 514-890-8000 ext 27466 [e-mail]

Principal Investigator: Fred Saad, MD, FRCS

-Patrick

[j-o-h-n]

You ask for info..... and you sure get it here.........

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 08/16/2020 11:57 AM DST