Urinary incontinence med.

[E2-Guy]

Have any of you warriors ever heard of a urinary incontinence drug called "Spasmo-lyt", 20 mg tablets? It is produced by Madaus in Germany and tablets contain 'Trospium chloride'. Have any of you ever used this med?

[cesces]

It has side effects typical of drugs like it, namely dry mouth, stomach upset, and constipation; these side effects cause problems with people taking their medicine as directed. However it doesn't cause central nervous system side effects like other drugs of its class.[3] It is pregnancy category C and is excreted somewhat in breast milk.[4]

Chemically it is a quaternary ammonium cation which causes it to stay in periphery rather than crossing the blood-brain barrier.[5] It works by causing the smooth muscle in the bladder to relax.[2]

It was patented in 1966 and approved for medical use in 1974.[6] It was first approved in the US in 2004, and an extended release version with once a day dosing was brought to market in 2007. It became generic in Europe in 2009 and in the US the first extended-release generic was approved in 2012.

Medical uses

Trospium chloride is used for the treatment of overactive bladder with symptoms of urge incontinence and frequent urination.[2][3][4]

It shouldn't be used with people who retain urine, who have severe digestive conditions, myasthenia gravis, narrow-angle glaucoma, or tachyarrhythmia.[2]

It should be used in caution with people who have problems with their autonomous nervous system (dysautonomia) or who have gastroesophageal reflux disease, or in whom fast heart rates are undesirable, such as people with hyperthyroidism, coronary artery disease and congestive heart failure.[2]

Trospium chloride is rated Pregnancy Category C,[4] as there are no adequate and well-controlled studies of trospium chloride in pregnant women and there were signs of harm to the fetus in animal studies. The drug was excreted somewhat in the milk of nursing mothers.[2] The drug was studied in children.[2]

Side effects

Side effects are typical of gastrointestinal effects of anticholinergic drugs, and include dry mouth, indigestion, and constipation. These side effects lead to problems with adherence, especially for older people.[3] The only CNS side effect is headache, which was very rare. Tachycardia is a rare side effect.[2

Https://en.wikipedia.org/wiki/Trospium_chloride

[E2-Guy in reply to cesces]

Thank you so much for the detailed and informative information.

[E2-Guy]

Thank you Nal.

[Magnus1964]

A quick search of Trospium chloride tells me it my not be any different than other drugs for over active bladder.

Most of these drugs are for over active bladder. If that is your problem. The only drug that works directly on the sphincter is imipramine.

[E2-Guy in reply to Magnus1964]

Thank you Magnus!

[Tall_Allen]

I've used a different antimuscarinic, Vesicare, and didn't like the side effects (mental side effects, dry mouth, etc.). Try it - see how you do with it. If bladder spasms are your problem, you may like Myrbetriq (mirabegron) better - fewer side effects.

[E2-Guy in reply to Tall_Allen]

Thank you Allen!

[j-o-h-n]

Depends.......

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 05/19/2020 7:46 PM DST

[E2-Guy in reply to j-o-h-n]

Yeah, I guess it all "depends" on how bad your problem is!