Rucaparib

[lewicki]

This has just been approved. What does this mean for life expectancy and

advanced prostate cancer?

[henukit]

Yep, good news fda.gov/drugs/fda-grants-ac...

It means that there's another tool in the collection to use in order to extend one' life. Overall response duration from different source 6-12 months. Then cancer adapts, resistance develops, and drug stops working as with many other drugs.

And it's applicable if you have failed previous SOC therapies and have metastatic castrate-resistant PCa and if you have BRCA1/2 mutation.

[tallguy2 in reply to henukit]

Excellent summary, easy to follow, thank you for posting this.

[Goldberg in reply to henukit]

It is great news I am taking olaparib.Does approval for Rucaparib Meaning that the cost will be covered. The Cost for olaparib Is $14,700 per month?

[lewicki]

Please post this. Thanks Nal

[bellyhappy58]

Pls do ...

[JazzMan42 in reply to bellyhappy58]

Me too!

[sgrama]

I’d like to see it. Thanks

[Gemlin_]

Meanwhile, for those who want to have some background reading:

en.wikipedia.org/wiki/PARP_...

[GreenStreet]

Would appreciate seeing Nal

[p96turbo]

only for braca 1/2, how about chek2

[Curehunter]

Please do. Thanks

[Pleroma]

Yes, please post a simplified version. Thanks.

[skateguy]

me too

[16starsky]

Please make it REALY simple Nal, for the likes of me !

[Lt036]

The simpler the better

Getting to where I can’t understand all the stuff put out

Thanks very much

[j-o-h-n]

Rucapa dance till you break a rib.......

youtube.com/watch?v=l0qeeLU...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 05/17/2020 4:49 PM DST

[lewicki in reply to j-o-h-n]

Great. Thanks for sharing.

[Cheerr]

Yes please do post a simplified version. Thank you.

[Easey]

Hey Nalakrats could you please include me thanks. I was on a trial which combined Rucaparib and Nivolumab, it was determined that I have a brca2 somatic mutation from a liver biopsy sample. I had probably a maximum 6 month benefit from the trial before it stopping working for me. Would in your opinion treatment with another Parp inhibitor such as Olaparib still be a choice ?

[ucladany]

Yes, please do it, if you have the time.

[vforvendetta]

I always appreciate and value your insight.

[sjc2]

Please, please post a simplified version. Thanks!!

[rx100m4]

I vote to see it.

[Nigu-1]

me to