In case you didn't see this. Not sure what this experimental drug (EPI-7386) is:
"EPI-7386 demonstrated a 20-fold improvement in androgen receptor-driven cellular potency over EPI-002. It is also highly stable in human hepatocytes and across animal species.
In vitro proliferation assays demonstrated on-target activity across a panel of prostate cancer cell lines, with activity in androgen receptor V7-driven cellular models."
"N-Terminal domain antiandrogens are a novel type of antiandrogen that bind to the N-terminal domain of the androgen receptor (AR) instead of the ligand-binding domain (where all currently-available antiandrogens bind) and disrupt interactions between the AR and its coregulatory binding partners, thereby blocking AR-mediated gene transcription. They are being investigated for the treatment of prostate cancer." [1]
"EPI-7386 – N-terminal domain androgen receptor antagonist for prostate cancer" [2]
-Patrick
Thanks for posting this.
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