Brain metastisis-

[DSEE]

Less than 5% of PC patients have brain metastisis .

My husband has joined that group-

Would like to know who else on this forum is fighting the same-

We both post here- but getting difficult for him to do so.

Treatment regimens for PC spread to liver and brain greatly appreciated!

[Hidden]

Most likely will be some combination of chemotherapy. Has he has a biopsy of the liver?

If the cancer has neuroendocrine cells, the doctor will probably prescribe Carboplatin, possibly in addition to Taxotere or Jevtana.

For the brain mets, he might also be able to get radiation and/or surgery, depending on the size and number.

Wishing the best for him.

[DSEE in reply to Hidden]

Cyber knife radiation done-

Cancer not neuroendocrine-

Liver biopsy 4-08-19

Did all chemo you mentioned but could not finish cycle.

Only one Jevtana treatment done but due to weakness did not continue.

Getting second opinion soon....,

There has to be a tolerable treatment out there!

[Hidden in reply to DSEE]

What is his doctor saying at this point?

[DSEE in reply to Hidden]

PT to strengthen -

But bone pain makes it hard-

The goal is to increase strength so he can have chemo again.

Tough goal !

Going to seek opinion from Emory University PC specialist next week.

It is rare to find others that have metastasized to brain-

Seeking info on what their treatment options have been.

Need answers from those treated for brain- liver Mets.

[kathim in reply to DSEE]

Good Morning,

Sorry to hear this.

My husband had Brain Tumor diagnosed this past summer. The Dr.'s were very hesitant to say it was a met from the PCa. as this is very rare. ( It was discovered with the newer Gallium Scan, in Michigan, in July, this was the only met. identified with the GA scan) (Michael had surgery in August at MA General) and it was removed, biopsy confirmed it was PCa. Post surgery, radiation to the site. Unfortunately,

his PSA never went down, and continues to climb and we are now going to Stanford CA for another scan to hopefully find out what is going on. No further treatment until we see what else is happening. Which area of the brain, was the tumor? Did they offer surgery as an option?

Thinking of you

K

[DSEE in reply to kathim]

There are 4 lesions in soft tissue of brain that were cyber knifed with radiation.

They want to scan every 3 months.

We have appointment next week for second opinion.

[Tall_Allen]

Did they do CyberKnife on the brain met? Some are using carboplatin+cabazitaxel for liver mets, followed by olaparib, but the platin and the PARP inhibitor doesn't seem to work well unless there is a BRCA1/2 mutation (somatic or germline). I don't know how well any of those medicines penetrate the blood/brain barrier.

[DSEE in reply to Tall_Allen]

Yes cyberknife 5 treatments done for brain lesions.

Second line taxotere plus carbo taken but after addition of carbo to taxotere became neutropenic.

Then did 1 treatment Carboplatin-

No response-

PSA rose to 496 with PSA doubling time very rapid.

MO felt cabazitaxel showed no benefit due to sharp PSA rise.

Personally felt he abandoned treatment too soon.

Not BRCA positive

So seeking another opinion-

Looking for options everywhere.

Seems there are few options is not BRCA positive .

That is frustrating.

[Tall_Allen in reply to DSEE]

How soon after cabazitaxel was the PSA taken? Sometimes there is an immediate rise in PSA attributable to cancer cells dying. Liver enzymes may also rise immediately but settle down with time. Neulasta may obviate the problem of neutropenia.

[DSEE in reply to Tall_Allen]

Neulasta was given after each chemo.

PSA was three weeks after cabazitaxel-

See MO Tuesday -

Regular MO then Emory on the 4 th.

I feel they abandoned chemo too quickly.

[Tall_Allen in reply to DSEE]

Three weeks should be long enough. I've talked to some patients whose QOL was improved by mitoxantrone, an older chemo drug. Perhaps QOL should be the main focus now.

[DSEE in reply to Tall_Allen]

PSA over a matter of 5 months went 44-76- 196- almost 500.

Chemo was going on during this time.

[Hidden]

I know that LU-177 PSMA-617 has been used in conjunction with radiation in patients with brain metastases with some success. Not sure if LU-177 has been successful alone, but something to look into.

[Mauvemood]

My husband had both. He started having trouble talking and the Doctor found he had some atrophy of his tongue. They radiated the spot in his brain and his speech improved but there is still atrophy. As far as the PC cancer of the liver, have you investigated Y-90 (Sir Spheres)?

[Currumpaw]

Hey DSEE,

The Japanese have been prescribing Polysaccharide K for decades for patients that have chemo. Polysaccharide K is Turkey Tail mushroom. It boosts the immune system. There is much info online about this.

Chemo weakens and suppresses the immune system. Chemo kills cancer cells but not---cancer stem cells, which have the ability to cross the blood, brain barrier--as does the vitamin C in intravenous, Vitamin C infusions. Vitamin C infusions can be helpful.

My best to you,

Currumpaw

[Hidden]

My guy has mets in bones, lymphnodes, liver, lung, and cerebellum. Recently, he had 4 cycles of carboplatium, etoposide and an immomtherapy drug.... These drugs are very toxic and harsh... He will have scans in 2-3 weeks...

[DSEE in reply to Hidden]

Name of immunotherapy drug?

Provenge?

[sgrama]

We just found out Monday Dec. 21st 2020 my husbands prostate cancer has spread to his brain. So sudden he started having seizures on Monday with no know.edge of it being in the brain yet. Now today he’s in hospice. I HATE CANCER!!!