Talapro2 8 weeks later

[Maleko808]

PSA dropped to .4, scans show no progression with 2 mets to ribs not showing. Also Alkaline Phosphatase down to 138. My MO is very pleased with results. So am I.

[Hidden]

Thanks for sharing these great results .. I remember when you first came on line here...It a battle royals with pc ...Finally a bit of respit for he and you . we can’t ever lay back and ignore pc completely ... now the goal is to keep it away for many years ..Take a deeeep breath, and live well....Scott🥳

[Maleko808 in reply to Hidden]

Thanks Lulu700. Yep, things seemed so out of control when I first joined. But with some help, some from this sight, and a refocus of what really matters I'm in a good place. This clinical trial is getting results! Hope you are doing well...Mark

[Hidden in reply to Maleko808]

I’ve been clear over four years now and I’m also on a trail drug . Keep rolling Mark ........peace and improving health to you .. Scott

[AlanMeyer]

That is great news. I didn't know anything about Talapro so I looked it up and learned that it's a novel PARP inhibitor that is good at killing cells that have DNA mutations that force them to rely on PARP to repair DNA and survive. One source said that 20% of PCa patients have the DNA repair mutations that force them to rely on PARP. It could be a real game changer for those patients.

Do you know yet if you were on the PARP drug + enzalutamide, or just on placebo + enzalutamide? Even if you're on the placebo, you're still doing very well. It means you have an excellent response to enzalutamide - also a good thing.

Best of luck.

Alan

[Maleko808 in reply to AlanMeyer]

My MO suspects I am getting the PARP drug based on other indicators. But like you said, either way the results are good.

[topofthemountain]

Fantastic news, great result. I signed up today for prescreening for genomic testing for DNA repair genes from tissue bisopy. If accepted, I will go into a phase 3 randomized, double blind, placebo controlled study of Talazoparib/Placebo and Enzulutamide. I am hoping I am accepted.

[Maleko808 in reply to topofthemountain]

Same trial I am on. So far great results and the side effects have been minimal. Hope you get in so we can compare notes.

[Hidden in reply to Maleko808]

This is great news! Thank you 🥳🥳🥳

[topofthemountain in reply to Maleko808]

I am hopeful. I will keep you posted.

[Hidden in reply to topofthemountain]

I pray it works well and keeps you on the. Topofthemountain.🙏

[topofthemountain in reply to Hidden]

Thank you Lulu700

[j-o-h-n]

Good news... happy for you..... (Maleko = Hawaiian for Mark?)....

Beat those tiny little monsters.........

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 11/21/2019 6:54 PM EST

[Maleko808 in reply to j-o-h-n]

Yep, Maleko = Mark. Go to Hawaii so often the locals call me uncle Maleko.

I am enjoying the smack down of these suckers.

[j-o-h-n]

Make sure that you don't change your name to Malaka if you ever decide to visit Greece.....

Keep on smacking.....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 11/22/2019 11:42 PM EST - JFK assassination 1963