How to know when Jevtana is no longer... - Advanced Prostate...

Advanced Prostate Cancer

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How to know when Jevtana is no longer working, is it PSA alone?

HOPEFULSPOUSE profile image
7 Replies

My husband's PSA has bounced around while on jevtana - 8 cycles now - but just spike 50% over a 2 week period. Have a call out to his onco but would love feedback here. Thank you!

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HOPEFULSPOUSE
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7 Replies
Tall_Allen profile image
Tall_Allen

You have to look at the whole picture, especially scan results. PSA can become a less useful biomarker over time.

HOPEFULSPOUSE profile image
HOPEFULSPOUSE in reply to Tall_Allen

Thank you - makes a lot of sense.

Raymonda100 profile image
Raymonda100 in reply to HOPEFULSPOUSE

My husband's PSA has never been higher than 18 in an 18 month period, but his scans from initial diagnosis have shown extensive bone mets. His oncologist told us that we should use only the scans to determine the effectiveness -- or lack thereof - of treatments.

I agree, you have to look at the bigger picture. You don't change treatments based on PSA alone. Imaging is more important along with how the person feels, pain symptoms, etc.

HOPEFULSPOUSE profile image
HOPEFULSPOUSE in reply to

Thank you so much - makes sense.

whatsinaname profile image
whatsinaname

Take a PSMA PET-CT scan and see whether the tumors have increased in size and qty. If they have, stop Jevtana as it is obviously not working. Only screwing up your husband's immune system.

HOPEFULSPOUSE profile image
HOPEFULSPOUSE in reply to whatsinaname

Thanks - great idea.

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