SUV in relation to PSMA pet scans

[Miguelnumerouno]

Anyone able to offer simple explanation of significance of fluctuation and rising

SUV....standard uptake values .....of tumour sites as detailed on 3 separate PSMA /Pet scans over a period of one year ?

Comments linked to PSMA avidity on same type of scan appreciated also.

Reason for question is to better understand the pathway to forthcoming Lu 177 and Actinium 225 treatment .

Thank you.

Michael UK

[Tall_Allen]

They have to look at SUV max relative to background. Didn't you get a radiologist's report?

[Miguelnumerouno in reply to Tall_Allen]

Thank you TA.. ...yes on each occasion of scan I received said report .....it seems my SUV readings have gone up progressively ( with a couple of fluctuations ) over the three that I have had ......I guess my question is :....

With the indicated rise is SUV generally .....does this indicate more avidity for lu177 and Ac225 combination to bind upon via the tracer ?

I really cant seem to knuckle down my understanding on this aspect of the problem.

Thank you for your help.

Michael

UK

[Tall_Allen in reply to Miguelnumerouno]

It depends upon what the report says. It's not enough for SUV max to be increasing - it has to be significantly higher than background. PSMA is the target for Lu-177-PSMA-617 and Ac-225-PSMA-617.

[Miguelnumerouno in reply to Tall_Allen]

Thank you very much....how do you fancy a private read

TA?

Michael

[Tall_Allen in reply to Miguelnumerouno]

Always a good idea to have it read by an experienced radiologist - especially with a fairly new scan.

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I’m pulling for you with upcoming treatments.. success for you ,might just spell success for others as well . Thanks