Risk Of Testosterone Flare??

[Dayatatime]

Interesting read and apparently no risk at all....

eu-focus.europeanurology.co...

Ron

[Startanew]

If you're getting lupron injections and taking casodex the odds of a flare-up are very small

[Dayatatime in reply to Startanew]

The article is stating there is not a need for anti-androgens at all with initial start up. The flare doesn't cause any harm. The standard of practice since the 80's has been to take an anti-androgen for a period when HT is started for seemingly logical reasons....there is nothing logical about this disease

[tom67inMA]

Very interesting. I didn't get an AA with my first Eligard injection, and in the weeks that followed did have a major increase in both pain and PSA. Of course, this could also be explained if my doubling time a month or less and it was just the natural progression of the disease until my T levels fell to a therapeutic level.

[pjoshea13]

Ron,

As he says - unless T is less than 250 ng/dl, the saturation point. I suspect that a significant percentage of men are.

-Patrick

[Dayatatime in reply to pjoshea13]

Does that mean if T is below the saturation point it can cause a PSA elevation and possible problems with a flare? Good point, especially since the majority of men with advanced disease are older and less testosterone.

Ron

[Tall_Allen]

My understanding is that antiandrogen preadministration is only needed when there are multiple bone mets, which the testosterone surge can make painful.

[ctarleton]

When I was first diagnosed 5 years ago at age 65 and very metastatic to many bones, I was still in a hospital with severe pain due to mets in the lower spine and also in the most enlarged lymph node. My T level was already at a relatively high 908. I was already on strong pain killers, and I was more than happy to have gotten the Casodex just prior to starting Lupron. The last thing I wanted was any chance of a further "testosterone flare". I just wanted the T level way down, and as fast as possible, and for that pain to go away (which it did within a couple of weeks).

[j-o-h-n]

If I knew having Pca would mean reading and reading and reading I would have told my doctor "fuck it. Never mind I don't want cancer, period".

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 02/13/2019 2:54 PM EST