Response with Lu PSMA 's first cycle for my father.

[Summm]

Hello Everyone,

I hope you all are slaying the big C each moment and emerging fitter and better by the day.

Since i took your feedback and opinion on the LU-PSMA trial for my father, before initiating.

I must write an update on his response to the treatment too. So Great news and bad news - both.

He took his first cycle on 11th Dec 2018, He didn't have any major difficulties or side effects, to say. No dry mouth etc. After 1- 2 weeks his pains started decreasing and now after nearly 6 weeks, his PSA dropped from 580 to 182, which is a great outcome. Although his legs are very weak to be out at work by his own, so he does stay home, but is definitely better and not struggling with the deadly pains.

Although he has shown hematotoxicity, which only under 10% patients show.

May be because his Bone marrow is affected by the disease or other reasons, but his Leukocyte counts has dropped to 3500 (normal being 4000 - 10000)

His Platelet cells have lowered to 93,000 (normal being 150,000 -450,000)

HB has dropped to 7.7 too.

He is being given whole blood transfusions and seen if the decreasing trend stops, his next cycle (already postponed to 11th feb) may have to further be postponed till the counts stabilize.

But over all he looks better and happy and i cant thank god enough for it.

Sending healing vibes to everybody on this community.

Om!!!!

[GP24]

This is a great result! I would suggest that your father exercises walking.

What you describe are common side effects of the PSMA treatment. About one third of the patients have Leukopenia, Anemia or Thrombocytopenia.

jnm.snmjournals.org/content...

[Summm in reply to GP24]

Thanks GP24. He did try to take short walks but unfortunately lost balance and fell down two times, so it worries him and us too. His disease has made him loose 26 kgs of weight and his legs seem toooo weak.

But for sure, after a few days, we shall ask him to try taking those walks again.

I hope the leukopenia, anemia and thrombocytopenia are managed well and he is able to take his second transfusion soon in time. It is definitely great to see him look and feel better.

[GP24]

To avoid falls he can use a rollator like these:

amazon.com/s/ref=nb_sb_noss...

Dr. Ryan thinks that exercise improves survival, see this article:

urotoday.com/center-of-exce...

[Summm in reply to GP24]

Thanks GP24 for sharing the useful links.

I think this rollator is great substitute to the walking canes. This might be useful.

Thanks Again.

[Carmen2]

What a great response! Sorry to hear the side affects are so troublesome. Hopefully they will resolve quickly. My husband just had his 3rd lu 177 treatment. He has not gotten dramatic psa reduction but has had a big reduction in pain.

Best Wishes

[Summm]

Thanks Carmen. Wow! Good to know about the your husbands PSA decline and pain reduction. Nothing better than not hearing about the pain.

Wishing your husband the best and positive vibes.

Om!

[Hidden]

Where did your Dad get his LU-PSMA treatment ?

[Summm in reply to Hidden]

Hi Mikew45

My Dad got his treatment at Rajiv Gandhi Cancer Research Institute, New Delhi, India.

[j-o-h-n]

Om to you too and namaste. You write as if you're in the medical field. Is that so? Sometimes support stocking help with his leg issues. Hopefully he will use a walker and get around to using his legs, because you don't want them to atrophy. I don't know if you're still in India but when I leave any east Indians I don't say namaste, I say "umustay" and "imustgo"...

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 01/21/2019 5:46 PM EST

[Summm]

Hi John!!

Dads PCa is teaching me a lot about medical field though i was engrossed in my own design and architects- wonderland.

We did try support stockings, made him very uncomfortable, his knees joints show degeneration and disease already- is the reason.

Thanks. I will surely encourage him to use rollaters/walker and be more mobile- want to see him that way.

'Umustay' and 'imustgo' is hillarious. I am definitely going to use it - handsfolded (namaste pose) :)))

Keep up the humour John.

Wish you the best of health and abundance of healing life force energy.

OM! 🙏🙏

[snoraste]

Great response to treatment. Studies have shown that early >50% drop in PSA has a good prognosis.

[Summm]

Thanks Snoraste for the reassurance. Looking forward an improving quality of life for him.

Wish you too the best of health and smiles. :))