After being tested there are no known gene mutations in my husband’s DNA. All mutations were checked that are known to attribute to prostate cancer. My question : is it a good thing or a bad thing? I know it’s good for my family but is it for my husband in that if you have a gene mutation doesn’t it make it easier to attack the specific cancer you have? Isn’t the new lymparza study targeting dna mutations? Just wondering? Thank you!!
No known gene mutations: After being... - Advanced Prostate...
We have men both with mutations, and without living for long times. They will probably be treated differently. But maybe just as important, is an exacting description, of the pathology. I.E. a poor pathology of lets say Ductal Carcinoma, with no gene mutation, may not be as bad as plain adenocarcinoma, with Gene mutations.
Interesting question. Lynparza (olaparib) is what is called a PARP inhibitor. Sometimes in people with various cancers, and specific inherited mutations (e.g. BRCA-2), they try using it to see if they can get the more rapidly-growing cancer cells which may have damaged DNA to die off at a faster rate than normal cells. However, roughly 90% of men with prostate cancer don't have any of the few kinds of inherited mutations like this.
(Personally, I'd rather not have a mutation such as BRCA-2, or whatever, which allows sporadic DNA damage in my cells to go unrepaired at the same time that my body is already dealing with advanced prostate cancer and various other treatments.)
For anybody here who may actually have one of these inherited mutations, here's a link that provides an update on research and progress in the field. Table 2 provides information about several single agent PARP inhibitors clinical trials in progress.
"ASCO 2018: Optimal Integration of PARP Inhibitors for Prostate Cancer: Which Test, Which Patient, and Which Therapy?"