Androgen Deprivation Therapy and Periodontal Disease

[cesanon]

ncbi.nlm.nih.gov/pubmed/172...

[pjoshea13]

It's good to know that BigPharma is interested in genetic variations that might be rare for a specific cancer but potentially profitable across all cancer types. Ultimately, this approach might be good news for some with cancers too rare to attract research funding.

"This is the second time the agency has approved a cancer treatment based on a common biomarker across different types of tumors rather than the location in the body where the tumor originated."

However, we have examples of drugs approved for one cancer being used off-label for another. Olaparib [Lynparza] was approved in 2014 for those with BRCA mutations & advanced ovarian cancer who had been treated with three or more prior lines of chemotherapy. In 2018, approval was extended to BCa patients. It has been found very effective for the minority of men with PCa who have genetic mutations in DNA damage repair genes.

But while a number of men here have been tested for BRCA variations, how long before testing for NTRK fusions becomes common?

-Patrick

[pjoshea13 in reply to pjoshea13]

cesanon,

This is odd! I was responding to your other post & had not even opened this one. Anyone else experienced this? -Patrick

[cesanon in reply to pjoshea13]

Nope

[20PeteG16 in reply to pjoshea13]

Yes, during my first Eligard series I developed dental problems and even with quick intervention by a noteworthy oral surgeon, I lost one molar. No problems since off Eligard.

PeteG

[j-o-h-n in reply to pjoshea13]

to pjoshea13:

Did you at least leave a little in the bottle for us?

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 12/08/2018 6:37 PM EST

[cesanon in reply to pjoshea13]

Now I am experiencing the same thing Patrick

[Emmett50]

Wow! I just talked recently to both my husband’s MO and dentist about this. Both of his top front teeth are about to fall out. Yes, he has had a lot of dental issues over the years but nothing like teeth falling out. Neither the dentist nor the MO thought ADT could have anything to do with his dental problem. I was testing the the theory that ADT either caused or accelerated bone loss and periodontal disease. They didn’t agree.

Since Paul hasn’t been able to work, we simply don’t have the funds for two dental implants. I was hoping to make the argument that since treatment caused the problem, perhaps some of the cost could be handled by medical insurance. I feel terrible for him that he’ll have to lose teeth on top of the effects of the ADT. His mood and self image are challenged enough. Anybody have any suggestions?

[cesanon in reply to Emmett50]

Not certain if the argument will work. My guess is you will need to appeal it.

First you appeal to the insurance company.

But now under Obamacare you will have a right to appeal to an independent arbitrator after you appeal to the insurance company and get turned down.

[cigafred in reply to Emmett50]

Similar experience. After about 1.5 years of ADT, loss of bone in lower jaw resulted in 3 lower front teeth falling out. Urologist said bone loss from ADT occurs in structural supporting bones (or something like that), this is unrelated. I had no gum disease, all else around those teeth was fine. Didn't think of trying to get help from medical insurance.

[Stegosaurus37]

I've been on Lupron for a year and a half now. I was warned about the possibility of osteoporosis and have been getting Zometa infusions and taking extra calcium for all this time. So far no problems.

We really have two diseases: the cancer and the treatment regimen. The interesting question is which one will get us first.

[cesanon in reply to Stegosaurus37]

The real issue is that you never ever want to mix zoneta with dental work. Ever.

[Stegosaurus37 in reply to cesanon]

More detail? I've had a filing replaced since I started and there didn't seem to be a problem.

[cesanon in reply to Stegosaurus37]

"Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw.[1] "

en.m.wikipedia.org/wiki/Zoledronic_acid

The above applies to all Bisphosphonates.

en.m.wikipedia.org/wiki/Bis...

I would schedule monthly visits to your dentist for a few months, and set something up so that if something seems untoward you can go to their office without an appointment.

[StonePilot]

Yes, be very weary of Zometa. There was an article in the NYT about 2004 and it saved my Jaw. I had extensive jaw necrosis and it took myself off of it to the objection fo my Urologist. It took years to grow back properly. In the Last three years a have had two teeth simply crack in half for no apparent reason. I have some mild osteoporosis after 19 years on continuous Lupron.