PC-SPES

[arete1105]

Anybody have any experience PC-SPES and PomT 10X It seems to act as a natural HT.

pcspes.net/

[tango65]

mskcc.org/cancer-care/integ...

[Tall_Allen]

PC-SPES was recalled for being adulterated with DES. The manufacturer stopped making it. If you want to try estrogen, talk to your oncologist.

Since all the ingredients in POM-T except broccoli extract has been proven to have no effect, why not just buy sulforaphane?

Be careful of stuff with outrageous claims that you see on the net. You are easy prey.

[arete1105 in reply to Tall_Allen]

Tall_Allen- here is another explanation for the presence of estrogenic activity in the PC-SPES product: nejm.org/doi/10.1056/NEJM19...

When the product was analyzed, it was found that the 8 herbs alone showed estrogenic activity w/o the actual pharmaceutical drugs present.

[pjoshea13]

When I joined PCa groups 15 years ago, the original PC-SPES was no longer available. I met a number of men online who were very bitter about the demise of the product. It had kept men with CRPC alive for a number of years & many of them died soon after PC-SPES was withdrawn.

There was a great deal of sympathy for Sophie Chen [New York Medical College], who had developed PC-SPES for her brother-in-law in Taiwan, who had PCa. Some blamed Chen's brother, president of BotanicLab, who ultimately took over production & marketing when word of the efficacy of PC-SPES spread.

PC-SPES was estrogenic. From a 1998 paper in the NEJM [1]:

"In complementary yeast assays, a 1:200 dilution of an ethanol extract of PC-SPES had estrogenic activity similar to that of 1 nM estradiol, and in ovariectomized CD-1 mice, the herbal mixture increased uterine weights substantially. In six of six men with prostate cancer, PC-SPES decreased serum testosterone concentrations (P<0.05), and in eight of eight patients it decreased serum concentrations of prostate-specific antigen. All eight patients had breast tenderness and loss of libido, and one had venous thrombosis. High-performance liquid chromatography, gas chromatography, and mass spectrometry showed that PC-SPES contains estrogenic organic compounds that are distinct from diethylstilbestrol {DES}, estrone, and estradiol."

Nonetheless, later researchers reported that some batches did contain DES, in varying amounts, & that marked the end of the product.

Sophie Chen didn't fit the profile of the usual shady character, with fake credentials, a clinic in Mexico & a long list of dubious products. I never heard anyone say something bad about her. Here are examples of her research work [2, 3]. She was devastated by the news of the contamination.

Which perhaps explains why there have been attempts by others to revive the product, which originally contained:

"chrysanthemum, isatis, licorice, Ganoderma lucidum, Panax pseudo-ginseng, Rabdosia rubescens, saw palmetto, and scutellaria (skullcap)"

It takes a lot of nerve to revive it under the discredited name.

I haven't heard any buzz about the new product. I wouldn't use it.

-Patrick

[1] nejm.org/doi/10.1056/NEJM19...

[2] ncbi.nlm.nih.gov/pubmed/115...

[3] ncbi.nlm.nih.gov/pubmed/215...

[arete1105 in reply to pjoshea13]

pjoshea13- I have some info I would like you to comment on, but I don't know how to insert a link to my desk top.