LU177

[JanJames]

Can anyone give me the details for the clinic in Munich which specialises in LU177 treatment.

Also what is the percentage of men who are suitable for this treatment?

Jan

[tango65]

Dr Tauber at the Technical University of Munich:

mriu.de/k_mit.html

or Dr Harun Ilhan at the Ludwig Maximilian University in Munich

[e-mail]

Only people with metastasis visualized with a Ga 68 PSMA PET/CT are suitable for the Lu 177 PSMA treatment. Most people with advanced PC are positive with this technique. People with Small cell or NEPC may have a low expression of PSMA and they may not qualify for Lu 177 PSMA treatment.

[JanJames in reply to tango65]

Many Thanks for the info

[Tall_Allen]

I would talk to Uwe Haberkorn at the University of Heidelberg because he is working on new ligands and new radioemitters:

Email: [e-mail]

Phone: [phone]

[JanJames in reply to Tall_Allen]

thank you

[tango65]

There are other places in Germany besides Munich and Heidelberg, such as Bonn and Bad Berka. I believe you could have more chances to be accepted outside a clinical trial in Munich or Bonn than in Heidelberg. I was not accepted by Heidelberg but I was accepted in Bonn, the Technical University of Munich and The Ludwig Maximilian University in Munich.

[WimS]

There are other places in the world were you can get LU PSMA treatment. I have had 2 injections over the last half year in Sydney. Dr Lenzo's company theranostics.com.au/ website is very informative. While being treated I have met a couple of Americans from the West coast who found it to be the best deal for them. It depends on where you live. I live in New Zealand. Each injection cost A$10.000 and you will also have to allow for the cost of the PSMA scans. I am at present on a wait and see period of 3 months. I do not have any treatment at present and my next PSA test is end August. Which will show how successful the treatment is. However Tall_Allen's comment about new ligands and new radio emitters is may be worth to go to Germany for, it is I believe the source for this type of treatment.

[TenscTexan]

I am the “3rd” test rat in a new clinical trial using Lu177-PSMA-R2, experimental,

phase I, group I, patient 3 of 3, saftey group. I got real lucky being at the right place at the right time and failing Zytiga just right.

This new trial that started last month in Phoenix. This trial uses a different ligand than the other Lu177 treatments. Not to say the current treatment doesn’t work, as it certainly is more beneficial than not having the treatment. What this clinical trial is trying to achieve is by making that ligand (PSMA-R2) more accurate at going to cancer vs other organs that produce the PSMA scent which is a risk right now in the development of this treatment. Currently, the treatment in Germany and Australia is Lu177-PSMA617. This NEW trial is Lu177-PSMA-R2. This trial is open to recruiting right now, but could be waiting lists as this begins to move quickly because the entire trial only includes 96 patients. Phase I, will be cycle of 3 treatments 6 weeks apart for 3 men at a time basically every 120 days so timing is very critical. This phase is the dose limiting phase, every one gets the juice. (Can’t cheat on this one, anyone can buy a radiation detector on eBay for $20)

I found out about this trial from this website, the specifics and qualifications are strict and must be in the correct sequence. If you can not meet these qualifications, don’t contact the clinic, there will be no exceptions and my fear for me is that my blood, bones, prostate, or PSA will get out of wack and they kick me out of the trial without getting the full three doses.

Diagnosis: mCRPC

Treatments: Hormone treatments, (Lupron or equivalent.)

Docetaxel, only one cycle, six treatments max.

PSA rising.

I take Zytiga and am required to continue through trial.

My PSA was rising on Zytiga, that sealed my entry qualification.

You must pass a PSMA-R2 Ga68 scan prior for PSMA expression.

I had my first infusion July 11th, so I’m 2+ weeks in. No side effects yet outside of some heavy fatigue after about 10 days but I can’t say it was this treatment, I’m weak from 5 months Zytiga. I call Zytiga my daily poison, I hate what it has done to me. Possible side effects are saliva gland damage and kidney damage although no proof of where this will go as it has never been put in humans. I took the chance, three oncologists agreed this treatment was my best shot at extending survival with less side effects than anything left in the bag of tricks they can offer me. No treatment I’ve tried so far has been considered successful..... PSA drops in the beginning of treatment and then bounces back up before treatment cycles ends.

I do plan to start a thread on this clinical trial but want to see if me mentioning this trial will overwhem the phone to an extent. I told them I was planning to talk about it and they said, sure, we need support and more interest, and more participants. They didn’t offer an email address for inquiries.

Here is a website explaining the process and qualifications:

drfabio.com/imagingblog/201...

[TenscTexan]

There are two clinical trials being done currently in the US using Lu177-PSMA617.

These trials are on a cost to patient trial, probably in upwards of $50K total.

UCLA is conducting a trial, and

Excel Diagnostics in Houston, (no affiliation with MD Anderson)

I understand both of these may still be recruiting.

The Lu177-PSMA-R2 trial mentioned above is a “no cost” to patient trial, only travel expenses.

I understand MD Anderson will also being doing a PSMA clinical trial at some point but I do not know what ligand it will use or the status of the cost.