My cancer

[jwick527]

I am interested in the high testosterone therapy. Can anyone suggest a dr. or clinic that might be able to help?

Thanks,

Jon

[Tall_Allen]

Do not attempt this outside of a carefully controlled clinical trial! It may help or it may speed the cancer's progression. Some (Liebowitz, MSK) have tried CONSISTENT high doses of T therapy with no proof of benefit and some proof it made it worse (you can read about it in the link provided). Even the BIPOLAR therapy has equivocal results. It should NEVER be used in symptomatic men.

You didn't say if you are castration resistant or still hormone sensitive. Here's are articles explaining what is known so far - read whichever applies to your situation:

pcnrv.blogspot.com/2016/09/...

pcnrv.blogspot.com/2016/09/...

[jwick527 in reply to Tall_Allen]

thanks Allen, I have no symptoms but scans show some activity. was on extandi + Lupron but recently went on Estradiol patches instead of Lupron. Shown to be just as effective in reducing testosterone without the side effects. Snuffy Meyers did a video on it awhile back. DenMeade is starting another trial in a month or so. I think I am castrate resistant at the moment. Also started Dexamethasone in conjunction with the patches.

[Tall_Allen in reply to jwick527]

Why do they give dexamethasone with the estradiol patches? They aren't doing that in the UK PATCHES trial. Tamoxifen would make sense to me.

[Break60 in reply to Tall_Allen]

Allen

Are these the same estradiol patches (changed twice weekly)I've been using to reduce hot flushes while on lupron or trelstar? How can they be if they're a substitute for LHRH agonists?

Bob

[jwick527 in reply to Break60]

Yes they are the same patches. When used with higher dosage and increased amount they can reduce T just as well as Lupron. Do some google searches and pull up a video by Dr. Snuffy Meyers who explains their use in replacement of Lupron especially in older patients who cannot tolerate the side effects of Lupron. Check my other post re: a protocol that a fellow used to keep his PSA down.

[Tall_Allen in reply to Break60]

Yes - just as high doses of testosterone results in LOWER testosterone production, estrogen does too. Estrogen was the first drug ever used against prostate cancer. There is still a lot to be learned, especially about optimal timing. It may be helpful with early metastases and harmful with late-stage metastases. A drug called Capesaris was developed that is an estrogen receptor α agonist, and it tested pretty well. It doesn't have some of the low-estrogen-related side effects that Lupron has. Clotting, while less of a problem with patches, still has to be watched.

[jwick527 in reply to Tall_Allen]

Re-read the link to the post by Doug and "a protocol that worked for me". He is very specific about what he did and the results that others got along with bone density etc. His methods worked for 4 out of 6 that he knows of. So far it seems to be working for me. Bone pain is 0. 4 @.1 mg Estradiol patches twice a week + 1 mg Dexamethasone a day. I have also done zoledronic acid, Prolia, Provenge, Lupron, Casodex, Extandi, IV vitamin C, IV Artemesia, IV Poly MVA. Its a battle...…..but life is worth the fight...…………………..

[Ptclassics]

I tried it in a clinical trial and it made my cancer grow

[jwick527]

Check out Dexamethasone research. Also, google estradiol patches + dexamethasone. There is a post by a fellow who used the protocol to great success.

paact.help/a-prostate-cance...

[Break60]

Here's a link to Dr Morgentaler. I called him about bi-polar TRT. He's used it for some guys who have PC but cannot stand ADT. But he admits its risky.

androgenstudygroup.org/memb...

[jwick527]

Thanks, DenMeade is starting a trial in the next few weeks combining TRT with immune therapy. I have seen him @ Hopkins, nice guy. I am off to a German clinic outside of Munich tomorrow for 3-4 weeks. I will let you guys know how it goes.

[jwick527]

I am in the Phoenix area

[rfarley01]

Jwick, I have been adding weekly T injections for many years, under Dr controls. Im 56 and my normal levels should have been between 600-900. Mine was 68 and I felt terrible. Also look up the Sloan Kettering study on it. If high levels of testosterone were a problem, young men should have Pca. I believe if caught as the levels start to drop, adding the injection weekly, you are actually being protected. The PCa doesn't start to appear until a mans T levels are depleted. Like belly buttons, thats My opinion only, except for the university study.

Testosterone Therapy in Men With Prostate Cancer. - NCBI - NIH

ncbi.nlm.nih.gov/pubmed/267...

by AL Kaplan - ‎2016 - ‎Cited by 26 - ‎Related articles

Testosterone Therapy in Men With Prostate Cancer. ... Program, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ... responsible for prostate cancer growth was based on elegant yet limited studies from the 1940s ...