Stem cells

Cells differentiate, and they can be put into a "tree" structure. The fully differentiated cells are the leaves of the tree, and the intermediates are the "stems". A stem cell is a cell that is not fully differentiated. The prostate cancer "stem" cells are cells that for some reason do not have all the characteristics of mature prostate cells. They are juveniles, and delinquents. A sort of new idea is that tumors also seem to have something called MDSC aka myeloid derived supressor cells. This is a goofy name. No leaf cell in the myeloid line has this name. Myeloid leaf cells include the red blood cells, and macrophages, and the neutorphils and the other phils. So these MSDC are juvenile delinquent Myeloid cells, probably would be macrophages when/if they grow up. The theraputic approach is to try to get rid of these MDSC cells, and see if then the immune system can recognize the juvenile prostate cells. Possibly the mature lymph cells think that these MDSC cells are adult macrophages, and so have the situation under control. However they don't.

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You had a biopsy that identified these undifferentiated cells! Yikes. The Gleason scale does not deal with these at all, AFAIK. Clearly this type of cell is a significant prognostic factor.

Something on that test: labtestsonline.org/tests/ch...

Makes sense to me, to rule out or downplay the suspicion of NET.

[CalBear74]

Hi Martin,

I would recommend reading the following text for a discussion of how to normalize cancer cells through the consumption of inositol hexaphosphate (IP6, aka "phytate", "phytic acid"). He also discusses cell differentiation.

amazon.com/IP6-Inositol-Nat...

I first started taking IP6 in the summer of 2015 and six weeks later had a PSA test. The results were a PSA lower than my urologist expected. He asked to perform a DRE and found no palpable nodules in my prostate (I am a stage 4, G 8 patient diagnosed in 2012). The author for the book is Dr. AKM Shamsuddin who discusses normalization and, at higher doses, apoptosis. I wrote him at the University of Maryland Medical School about my results and he told me cell normalization explains the disappearance of the nodules. My current therapy is Lupron every six months. My PSA has trended lower and has been 0.06 since 2017.

The second book you would enjoy, in light of your comments, is Dr. Vaclav Vetvicka's "Beta Glucan: Nature's Secret". He is a biochemist doing research at the University of Louisville Medical School. You can get a quick intro to beta glucan at vitawithimmunity.com where numerous physicians and Dr. Vetvicka are interviewed.

amazon.com/Beta-Glucan-Natu...

Your happy vegan, CalBear74