Genetic testing found several genomic alterations

I have castrate-resistant prostate cancer and am just finishing my second line of treatment, which is Zytiga w/prednisone (PSA went from .94 in late September to 3.84 in November). My oncologist suggested genetic testing, and the results just came back. I have these genomic alterations identified: ATM Y2755fs, BRAF ZC3HAV1-BRAF fusion, ERBB3 S846I, CDK12 S343fs*8, W920fs*26, MDM4 amplification - equivocal and PIK3C2B amplification - equivocal. If you are so kind, please let me know if you have any of these mutations and what treatments they opened up for you.

6 Replies

  • Here's a really good article that goes into many of the gene mutations in prostate cancer and the targeted treatments available for them. It's called: Molecular landscape of prostate cancer: Implications for current clinical trials

  • Thank you gregg57, for the link.


  • Hi gregg57, thank you so much for the link. It article is loaded with great information and I'm learning quite a bit while reading it. You've been a big help, and I really appreciate it!

  • Thanks

  • Good Morning joeinwis,

    From the results from a Guardant360 liquid biopsy, we discovered that my cancer had an ATM defect. Dr. Charles "Snuffy" Myers then prescribed Lynparza, a PARP inhibitor, which worked for me for about 9 months. As it retails for about $10,000/month, you must have insurance coverage.

    Best wishes. Never Give In.

  • Hi vandy69, thank you for sharing your experience. My oncologist and I discussed PARP inhibitors, and it appears that this medicine or a similar one is in my future. Thankfully, I do have good insurance (I went 15 years without good insurance and stumbled into a job with great insurance just 14 months before being diagnosed). What a blessing! Best wishes to you, too. I hope and pray all is well.

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