New study below [1].
"A microRNA ... is a small non-coding RNA molecule ... found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression." [2]
"Growing evidence indicates that deregulation of the epigenetic machinery comprising the microRNA (miRNA) network is a critical factor in the progression of various diseases, including cancer. Concurrently, dietary phytochemicals are being intensively studied for their miRNA-mediated health-beneficial properties, such as anti-inflammatory, cardioprotective, antioxidative, and anticancer properties. Available experimental data have suggested that dietary polyphenols may be effective miRNA-modulating chemopreventive and therapeutic agents."
"Resveratrol downregulated ... members of the oncogenic miR-17 family of miRNAs, which are overexpressed in prostate cancer."
"We have functionally validated the miRNA-mediated ability of resveratrol and its potent analog pterostilbene to rescue the tumor suppressor activity of PTEN in vitro and in vivo."
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/286...
Ann N Y Acad Sci. 2017 Jun 29. doi: 10.1111/nyas.13372. [Epub ahead of print]
Resveratrol and pterostilbene as a microRNA-mediated chemopreventive and therapeutic strategy in prostate cancer.
Kumar A1, Rimando AM2, Levenson AS1.
Author information
1
Arnold and Marie Schwartz College of Pharmacy and Health Sciences, Long Island University, Brooklyn, New York.
2
United States Department of Agriculture, Agricultural Research Service, Natural Products Utilization Research Unit, Oxford, Mississippi.
Abstract
Growing evidence indicates that deregulation of the epigenetic machinery comprising the microRNA (miRNA) network is a critical factor in the progression of various diseases, including cancer. Concurrently, dietary phytochemicals are being intensively studied for their miRNA-mediated health-beneficial properties, such as anti-inflammatory, cardioprotective, antioxidative, and anticancer properties. Available experimental data have suggested that dietary polyphenols may be effective miRNA-modulating chemopreventive and therapeutic agents. Moreover, noninvasive detection of changes in miRNA expression in liquid biopsies opens enormous possibilities for their clinical utilization as novel prognostic and predictive biomarkers. In our published studies, we identified resveratrol-regulated miRNA profiles in prostate cancer. Resveratrol downregulated the phosphatase and tensin homolog (PTEN)-targeting members of the oncogenic miR-17 family of miRNAs, which are overexpressed in prostate cancer. We have functionally validated the miRNA-mediated ability of resveratrol and its potent analog pterostilbene to rescue the tumor suppressor activity of PTEN in vitro and in vivo. Taken together, our findings implicate the use of resveratrol and its analogs as an attractive miRNA-mediated chemopreventive and therapeutic strategy in prostate cancer and the use of circulating miRNAs as potential predictive biomarkers for clinical development.
© 2017 New York Academy of Sciences.
KEYWORDS:
biomarkers; microRNAs; prostate cancer; pterostilbene; resveratrol
PMID: 28662290 DOI: 10.1111/nyas.13372
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