Anti PD1 immune therapy

[podsart]

Has anyone had any experience with anti PD1 immune therapy? How were the side effects, especially cases where unleashed immune system starting to attack healthy organs, how were they handled?

[ctarleton]

Some related info here:

uptodate.com/contents/toxic...

Charles

[podsart]

Thanks

[podsart]

Thanks - immunology is a specialty that my new dr has, he has mentioned use of anti pd1 therapy as possibility

[sfboy58]

I was on an anti-PDL1 with Xtandi clinical trail at the NIH for almost one year. During that time my PSA and bone lesions remained stable. The only major side effects I had was dry mouth. I continue to take pills to help with the dry mouth which means the damage was permanent.

[podsart in reply to sfboy58]

So your Pca stayed unchanged despite combined effect of anti PD1 and Xtandi

Do you mind sharing more about your Pca, Gleason , staging , prior protocols?

Did they say what was damaged to create dry mouth symptom?

Thanks

[sfboy58 in reply to podsart]

I was diagnosed in 2002 with Gleason 4+3 (7) and PSA of 6.6. I had my prostate removed and after a few months my PSA began to rise and I had salvage radiation in 2003. My PSA was undetectable for two years then started to rise with a 12 - 15 month doubling time from 2006 to until August 2012 (PSA range 0.1 to 1.7) . I have had many treatments since then . My PSA while on the NIH imunotherapy clinical trial remained in a range from 30 to 70. It bounced around a lot, but my scans were always stable. The dry mouth was probably caused by the immunotherapy drug, but it was a new side effect that only several people on the clinical trial experienced. You can read details of my treatments on my profile page. I am currently on cabazetaxel with carboplatin and my PSA ranges from 2500 to 3000, but my scans have been stable since I started this protocol.

[podsart]

I also have Gleason 4+3, had RP and subsequent biological recurrence.

One thing may interest you, my Dr ( retiring nov1), strongly believes in Caris labs to obtain genetic info and associated drugs that prob work and which won't and the newer Guardant 360 blood drawn genetic test to see what's happening real time genetically with Pca.

If your have mutation of your brac1/2, ATM, or Chek genes, lymparza has been found help many rather strongly

Found my PTEN gene was silenced epigenetically via hyper methylation, so this key cancer brake doesn't work for me

Thanks for your info, wish you much luck