A Prostate Cancer Patient’s 24-Year (1992-2016) Continuing Journey From Diagnosis to Treatment to Recurrence to Mentoring

[maack1]

A Prostate Cancer Patient’s 24-Year (1992-2016) Continuing Journey From Diagnosis to Treatment to Recurrence to Mentoring tinyurl.com/hcxuxv9

[joeoconnell]

many many thanks Chuck for your dedication and sharing. you may never know how many you have helped

[Hidden]

WOW!!! Chuck, you are God's gift to all - PCa patients current and prospective, their caregivers and their doctors.

[Rogersw]

24 years wow!. Your posts here in the UK have been greatly appreciated too. Thank you.

[CERICWIN]

Chuck, you've helped so many of us with your untiring efforts and endless research, and especially your willingness to give individual attention whenever asked.

You are a true humanitarian, you love your fellow man and your country.

I'm deeply honored to call you friend and brother.

CERICWIN (Eric)

[maack1]

"Always as close as the other end of your computer....."

[yope4]

Thanks Chuck for sharing the experiences and discoveries through your journey. You put in a lot of work to provide the many references you cited. Thank you.

[WendyL]

You continue to inspire, dear Chuck!

[Magnus1964]

I was also diagnosed 24 years ago, been through surgery, every hormonal ablation drug, radiation, and immune-therapy. The battle goes on. I am presently on the Eli Lilly drug trial that uses xtandi and the Lilly drug or placebo. Whether I am on the real drug or a placebo, the xtandi has taken my PSA from 130 to 25. The battle goes on.

[maack1 in reply to Magnus1964]

Congratulations! We are beating the odds! Tell me more about the trial and what is the Lilly drug?

[Magnus1964]

The trial started in April. I get xtandi and another bottle of something labeled LY3033514 or placebo. It is a blind study to measure how much longer men get a benefit from xtanti with this other mystery drug. So I don't know if I am getting the mystery drug or a placebo. Whether it's the drug or not I am responding well to the xtandi. My PSA went from 130 to 25 so far.

In spite of the gleason 9 score I got 24 years ago I have responded well to all treatments I have received. With a few drugs I have had bad side affects and had to stop them. But as long as medicine keeps coming up with new therapies I am happy.

[maack1]

As identified here, LY3023414 in the trial is a PI3 Kinase/mTOR Inhibitor:

clinicaltrials.gov/ct2/show...

This paper explains the activity of a mTOR inhibitor:

ncbi.nlm.nih.gov/pmc/articl...