I had a Radical Prostatectomy, NSP, 3-23-99, at Kaiser Hospital, Baldwin Park, California. My Urologist, diagnosed a stage T1c adenocarcinoma of the prostate with PSA of 11.78, and Gleason Score 3+4=7 preoperatively and postoperatively. Subsequently my pathologist, reported that the tumor focally extended through the capsule, with microscopic invasion into adjacent soft tissue; tumor present in margin in right prostate; rare Foci consistent with vascular invasion; apical and bladder neck margins, seminal vesicles, vas deferens, and lymph nodes negative for malignancy. She diagnosed the malignancy as Gleason Score 3+5=8 postoperatively. In 2000, it was confirmed that I was in biochemical failure and following consultation with my Oncologist, I initiated EBRT.
Subsequent to the radiation washout my PS declined to .002, and then I used pomegranate to decrease the doubling time, Bee Propolis to prevent tumor formation, and PSP to induce aptosis. This worked until around 2012 when my PSA began to rise dramatically. I then initiated intermittent Lupron treatment bringing me down to 0.94 ng/mL. Subsequently I have used intermittent Lupron treatment and natural substances from all over the world to maintain my life. I resume Lupron treatment when my PSA rises to around 10 or 11 bringing it down to below two almost every time.
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Can you tell me what PSP is? Also how did you ingest the pomegranate and propolis. I'm a bee keeper so have ample supplies of propolis. Also would you mind sharing what the other natural substances are that you are using. I'm castrate resistant with 5 mets currently taking Zytiga daily (for past 12 months), Lupron every 3 months and Xgeva monthly. Xgeva strengthens my bones. To date my PSA has leveled off at 14.7, rising from a low of 7. Am looking at all paths to suspend the progression and have only scratched the surface of natural plant based options. Thanks in advance.
An over-the-counter natural remedy derived from honeybee hives arrests the growth of prostate cancer cells and tumors in mice, according to a new paper from researchers at the University of Chicago Medicine.
Caffeic acid phenethyl ester, or CAPE, is a compound isolated from honeybee hive propolis, the resin used by bees to patch up holes in hives. Propolis has been used for centuries as a natural remedy for conditions ranging from sore throats and allergies to burns and cancer. But the compound has not gained acceptance in the clinic due to scientific questions about its effect on cells.
In a paper published in Cancer Prevention Research, researchers combined traditional cancer research methods with cutting-edge proteomics to find that CAPE arrests early-stage prostate cancer by shutting down the tumor cells' system for detecting sources of nutrition.
"If you feed CAPE to mice daily, their tumors will stop growing. After several weeks, if you stop the treatment, the tumors will begin to grow again at their original pace," said Richard B. Jones, PhD, assistant professor in the Ben May Department for Cancer Research and Institute for Genomics and Systems Biology and senior author of the study. "So it doesn't kill the cancer, but it basically will indefinitely stop growth."
To study the purported anti-cancer properties of CAPE, first author Chih-Pin Chuu (now at the National Health Research Institutes in Taiwan) tested the compound on a series of cancer cell lines. Even at the low concentrations expected after oral administration, CAPE successfully slowed the proliferation of cultured cells isolated from human prostate tumors.
CAPE was also effective at slowing the growth of human prostate tumors grafted into mice. Six weeks of treatment with the compound decreased tumor volume growth rate by half, but when CAPE treatment was stopped, tumor growth resumed its prior rate. The results suggested that CAPE stopped cell division rather than killing cancerous cells.
To determine the cellular changes that mediated this effect, the researchers then used an innovative proteomics technique invented by Jones and colleagues called the "micro-western array." Western blots are a common laboratory tool used to measure the changes in protein levels and activity under different conditions. But whereas only one or a few proteins at a time can be monitored with Western blots, micro-western arrays allow researchers to survey hundreds of proteins at once from many samples.
Chuu, Jones and their colleagues ran micro-western arrays to assess the impact of CAPE treatment on the proteins of cellular pathways involved in cell growth -- experiments that would have been prohibitively expensive without the new technique.
"What this allowed us to do is screen about a hundred different proteins across a broad spectrum of signaling pathways that are associated with all sorts of different outcomes. You can pick up all the pathways that are affected and get a global landscape view, and that's never been possible before," Jones said. "It would have taken hundreds of Westerns, hundreds of technicians, and a very large amount of money for antibodies."
The micro-western array results allowed researchers to quickly build a new model of CAPE's cellular effects, significantly expanding on previous work that studied the compound's mechanisms. Treatment with CAPE at the concentrations that arrested cancer cell growth suppressed the activity of proteins in the p70S6 kinase and Akt pathways, which are important sensors of sufficient nutrition that can trigger cell proliferation.
"It appears that CAPE basically stops the ability of prostate cancer cells to sense that there's nutrition available," Jones said. "They stop all of the molecular signatures that would suggest that nutrition exists, and the cells no longer have that proliferative response to nutrition."
The ability of CAPE to freeze cancer cell proliferation could make it a promising co-treatment alongside chemotherapies intended to kill tumor cells. Jones cautioned that clinical trials would be necessary before CAPE could be proven effective and safe for this purpose in humans. But the CAPE experiments offer a precedent to unlock the biological mechanisms of other natural remedies as well, perhaps allowing these compounds to cross over to the clinic.
"A typical problem in bringing some of these herbal remedies into the clinic is that nobody knows how they act, nobody knows the mechanism, and therefore researchers are typically very hesitant to add them to any pharmaceutical treatment strategy," Jones said. "Now we'll actually be able to systematically demonstrate the parts of cell physiology that are affected by these compounds."
The paper, "Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of p70S6K and Akt signaling networks," will be published online May 4 by Cancer Prevention Research. In addition to Chuu and Jones, authors include Mark F. Ciaccio, John M. Kokontis, Ronald J. Hause, Jr., Richard A. Hiipakka and Shutsung Liao of the University of Chicago; and Hui-Ping Lin of the National Health Research Institutes in Taiwan.
Research was supported by grants from the Cancer Research Foundation, American Cancer Society, National Institutes of Health, U.S. Department of Health, and National Science Council.
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(I recommend you go online to durhamsbeefarm for a website full of advice on the medicinal uses of bee substances. Perhaps you can create your own with the help of your bees. Bee derivatives are also available by perscription in Russia but I'm unaware of their pharmacopia)
Essence of Yunzhi Polysaccharide Peptide (PSP) contains protein bound polysaccharide
extracted from the mycelia of the COV-1 ® strain of the polypore mushroom. Only the YUNZHI variety, using the Canadian extraction method is a known as an active Aptosis inducing Naturopathic Anti-Cancer formulation. As such, the names of Yunzhi (as known in TCM), Coriolus Versicolor, Trametes versicolor (also known scientifically as Polystictus versicolor), Kawaratake (as known in Japan) and Turkey Tail (as known in North America) are commonly associated the same organic form of this organic mushroom product.
Polysaccharide Peptide (or PSP, as known in TCM) and Polysaccharide Krestin (or PSK, as known in Japan) are names commonly associated with the extracted, concentrated form of this polypore mushroom’s active ingredients.
PSK, the relative to PSP, the pharmacological version, is the most widely prescribed Anti-Cancer Drug in Japan and is approved to both prolong life, reduce pain, and increase the effectiveness of chemotherapeutic drugs. It has been around for quite a while and simply Googling it will produce lots of information.
PSP has had a number of significant trials in Europe, Asia, and Australia, and is presently becoming widely used in the treatment of Pancreatic Cancer.
Vitamin E Tocotrienol Shows Increased Cancer Cell Apoptosis Without Toxicity In Phase 1 Pancreatic Cancer Trial
Davos Life Science (DavosLife) has announced preliminary results of a phase I clinical trial of its Natural e3 delta-tocotrienol (Natural e3) in patients with resectable pancreatic cancer. Tocotrienols are highly potent members of the Vitamin E family that have been found by researchers to inhibit the growth and survival of various types of cancer cells. This clinical trial revealed that Natural e3 was able to increase apoptosis (cell death) in pancreatic cancer tumours, with no toxicity. The study was carried out by researchers at The H. Lee Moffitt Cancer Center & Research Institute in Florida, United States, and supported by DavosLife and by the U.S. National Institute of Health. This data was presented by the Moffitt Cancer Center at the recent American Association for Cancer Research (AACR) Annual Meeting.
For a period of 2 weeks prior to surgery, 12 subjects received Natural e3, with 3 subjects at each dose level of 200 mg, 400 mg, 600 mg and 800 mg per day. This oral treatment occurred pre-surgery to examine the effect of Natural e3 on the resected pancreatic cancer tumour. To assess for toxicity, blood samples were collected pre-dose on day 1, day 8, on the day of the patients' surgery and 3-6 weeks post-surgery. This trial occurred between October 2009 and August 2010.
The Moffitt Cancer Center researchers, led by Dr Mokenge Malafa, found no adverse drug-related events in the patients and no change in the rate of post-operative complications at doses up to 800 mg per day. They also found that giving patients daily doses of Natural e3 greater than 200 mg increased apoptosis in the pancreatic tumours as well as increased expression of p27, an important kinase inhibitor involved in the regulation of the cell cycle. Reduced levels of p27 have been found in some types of cancers.
"Pancreatic cancer is a highly fatal form of cancer with average 5 year survival rates at less than 10% from the time of discovery. We at The Moffitt Cancer Centre are researching into novel but safe compounds that could potentially help cancer patients. We are very pleased by the good biomarker activity and tolerability profile of Natural e3 found so far in our pancreatic cancer patients. We are moving ahead with the Phase I dose escalation trial with the next dose level of 1600mg per day already in progress," said Dr Malafa, Head of Pancreatic Oncology, at The Moffitt Cancer Center. Two phase 1 trials of Natural e3 in healthy subjects have also been initiated at the Moffitt Cancer Center.
"We are pleased to be supporting Moffitt's early Phase clinical trials of Natural e3 for cancer prevention and treatment. DavosLife is supplying all of the Natural e3 as well as part funding for the trials. Tocotrienols have been shown by various researchers to have good bio-activity in a range of human diseases. This is part of our efforts to advance the research into tocotrienols into new areas," said Mr Arthur Ling, CEO of DavosLife.
Clinical Studies of its effectiveness against PCa have been underway for some time in both Europe and Asia and have recently been initiated in the United States. Some of the preliminary reports indicate the substance is very promising.....
Thanks for sharing your story and looking forward to hearing more. Had you tracked your doubling time pre and post the use of pomegranate. I ask because it made no difference in my doubling time when I took it, my doubling time as been less than 6 months with and without it.
Pomengranite must be of the Wonderful variety. There are several encapsulated Israeli varieties that are better than drinking juice. The juice is very sweet and sweets of any kind are bad for cancer. I used it twenty years ago prior to NSRP when my PSA was 11 and it more than halves it in two weeks and then gradually brought it down to less than 2. It is a phytoestrogen therefor I would not recommend it to someone who is experience biochemical failure.
My golden rule is that wherever there is a natural substance that may enhance, replace, or assist in treating you disease do not be afraid to try it!
Thanks for sharing. My Naturopath has me on a ton of supplements that cost a fortune. Much of it is to boost my immune system (with RIBRAXX derived from shiitake mushrooms and rice bran) and Vitamin D oral spray.
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Diagnosed with Stage 4 Metastatic PCa in the end of May
Hx of heavy alcohol use may be associated with more aggressive PCa
New to site. Diagnosed at 50. 
Homocysteine, hypermethylation/PCa aggressiveness and MTFHR mutation
Post RALP path report 
