{Questions}Active Surveillance, how long have you been doing it? How many require treatment?

[santer]

I received my biopsy results received last week. Gleason 6.

First opinion (from Uroligiost) is active surveillance. I have questions for the Urologist that are being followed up right now.

I will be seeking a second opinion.

My current research so far is in line with this opinion / suggestion.

A couple of pieces of research I haven't found answers too. If you know, please share. And / or share you experience(s)

QUESTION 1: What percentage of Active Surveillance individuals never require treatment?

QUESTION 2: For the folks who do require treatment, what are the percentages

- 5 years out

- 10 years out

- 15 years out

[RMontana]

This article takes you down the road a bit, but have you gotten a good scan of what you have; to fix a 'baseline' now and see going down the road if the tumor has grown. One way is to get a Multi Parametric MRI of the pelvis...another is what I would do as well is to get a PSMA PET scan. If your PSA is higher than a 0.20 (which is most likely is), it will work...use it to find out if you have PCa anywhere else and exactly where you have it in the gland...but, talk to your doctor and see if the MRI is better for the area of the Prostate itself. A PSMA PET otherwise will at least let you know (for sure) that you dont have PCa anywhere else...rule that out as well then 'watch' the tumor and see if it grows...a close friend saw his tumor grow by 100% in one year via a Pelvic MRI...but if you are not considering imaging, give it a second look...DRE's are IMHO are pretty useless...good luck...

210722 ART New Indications for PSMA and GRPR Imaging, Prostate Cancer Treatment Pipeline

Biology guided radiation therapy from a company called RefleXion. So instead of using the anatomical signal to guide the X-ray beam for external radiation you use the PET signal to do that

For many of the PSMA agents, evaluation of the prostate bed may be limited by the fact that the urine contains the drug.

So one potential benefit for Axumin is evaluating the prostate bed.

There are PSMA agents like PSMA-1007 with less urinary excretion that do not have the disadvantage.

PSMA agents have significant advantages over fluciclovine in terms of detection of disease at low PSA levels, such as <1 ng/ml. So it’s there where PSMA has significant advantages.

If you go to levels of PSA greater than five, the positivity rate between the two (Axumin) I think is comparable.

Trial with 10 participants who were involved, a pilot study, overall, both PSMA and RM2 (68Ga-RM2 is a synthetic bombesin receptor antagonist) had accuracy in the mid-80% range.

We saw a sensitivity of 100% for both of them and

specificity of also mid-80%.

healthunlocked.com/api/redi...

[EJC61]

I think the general figure given is 50% will need intervention in 10 years.As far as your case, you can get a second opinion by having slides sent to Johns Hopkins. You should also probably ask your team about getting a 3TmpMRI as additional data before pushing forward with AS and ideally annually going forward. Then clearly is quarterly PSA testing and annual DRE. I've been on AS for 4 years.