Hi, Has anyone used this diet to loose weight when on warfarin? Two days in the week, either back to back or apart, you eat 500 calories for a woman, 600 for men. The other 5 days you eat "normally". Sounds like you can loose weight gradually, and I think it is a diet that I can manage around my family. Since being on warfarin, I have gained weight, mainly due to a big change in my lifestyle, and I believe that the warfarin makes me more lethargic. I regularly get my INR checked, and since I eat very seasonaly (what is growing current in my garden) my INR does vary according to my diet. ie. rhubarb, asparagus, etc. Summer eating more salads tends to raise my INR. I will talk with my GP about wanting to do this 5:2 diet before I start.