Blue Horizon Thyroid DNA results AA worse than GG?Also mention graves disease but been diagnosed with Hypothyroidism years ago?

[Stace268]

Does anyone understand this result?

[Jaydee1507 Administrator]

These type or test results take a bit of interpreting and you cannot take them literally. This is because you can carry the gene and as yet it hasn't been 'switched on'. It may never be switched on and the roll of the genetic dice for you has meant you got hypo, possibly Hashi's.

I've run myraw dna through a functional gene analyser and I carry genes for certain autoimmune bowel conditions which as yet I do not have. Maybe I will never have them if the genes don't get switched on. Maybe I will get them later in life. Welcome to the genetic lottery. 🙂

[Stace268 in reply to Jaydee1507]

I guess if I asked my GP do the test for graves I'd know. But my T3 always been quite near bottom of normal and T4 near top of range.

The strange thing is symptom of graves is heart failure n stroke my grandad had several strokes before he died, my dad has heart failure n me n my son get chest pains. A cardiologist told my dad he had Type of high cholesterol you're born with not from diet.Is it possible to use this data to genotype or whatever they call it?

Thinking I just paid over £100 for nothing 🙃

[Jaydee1507 Administrator in reply to Stace268]

The strange thing is symptom of graves is heart failure n stroke

This only happens if it is untreated. If you have been diagnosed as hypo and on Levo/T3 then it's highly unlikely you have Graves. I highly doubt your relatives do either as they would have had symptoms of Graves and been diagnosed/treated.

There are many causes of heart failure and stroke, these are things that run in my family too but certainly 2 of my relatives that have heart failure don't have any thyroid issues.

If you have a genetic tendency in your family to hypercholestrolemia I would talk to your GP and ask them to run tests for you.

It's nice that we can order tests but we need to be very careful to pick the right test to show what we need.

What is it that you want to find out with a test?

[Stace268 in reply to Jaydee1507]

I've ready had cholesterol tests that's one of reasons they suspected hypothyroidism as it was raised.Just don't understand the DNA test really

[Jaydee1507 Administrator in reply to Stace268]

They are using a traffic light system to indicate if the genes you have a risk for specific issues.

Green is good and there is no risk, yellow maybe a risk and red a definite risk. As I have said before though these genes are not necessarily activated.

It looks like you convert levo well.

[Stace268 in reply to Jaydee1507]

Though T3/T4 ratio was not good on thyroid panel. Do you understand the GG ?

[Jaydee1507 Administrator in reply to Stace268]

In the photo in the main post I can't see what it relates to as there is a red circle over a word. Is that DIO2?

I'm really only a very basic amateur at this and explaining it might be hard for me. You inherit one copy of each gene from both parents. Depending on what you inherit determines whether you get an A, C or G result. So the two letters you have relate to what you inherit from each parent. Different combinations obviously give different results.

dnafit.com/advice/dna-testi...

I don't see a result for DIO2.

[Stace268 in reply to Jaydee1507]

GG result refers to TRHR-Thyrotropin Releasing Hormone (TRH) Receptor Responsible for the body's receptivity to TRH which stimulates the secretion of TSH from the pituitary gland. In turn, TSH stimulates the production of thyroid hormones from the thyroid gland. TRH is an important part of the negative feedback loop that ultimately

regulates thyroid hormone levels. Variants have been shown to affect TSH

[Jaydee1507 Administrator in reply to Stace268]

As you are now being treated for hypothyroidism it's probably less relevant now as your T4/T4 is coming out of a packet as opposed to relying on any feedback looks to the pituitary.

[Stace268 in reply to Jaydee1507]

Think the oestrogen will be less of a problem in menopause as well. So yay something to look forward to

[CoeliacMum1 in reply to Stace268]

Look up a few articles from Hormone balance on Instagram or Facebook regarding oestrogen. There’s actually more to it than thinking oestrogen will be remedied re menopause. We need to eliminate bad oestrogen’s as these cause serious problems for women also our fat cells make oestrogen too, even though our ovaries may decline in production…we have several types of oestrogen some good and others recycling that are bad and need elimination - I’ll try and find a link that explains this along with good bad oestrogens and edit this post as I won’t remember crucial information without reminding myself so won’t explain it very well.

beingbrigid.com/estrogen-do...

Ignore the title of oestrogen dominance, but this article is full of information regarding the types of oestrogen and what they do…

[bookish in reply to CoeliacMum1]

Great article, thanks for the link.

[Stace268 in reply to CoeliacMum1]

Would estrogen cause chest pain and problems with blood n arteries etc? I've noticed my son has a tiny bit of Gynecomastia and my dad also has some of that and his had all sort of problems with heart estosterone prostate etc

[CoeliacMum1 in reply to Stace268]

Sorry I have no idea, best ask your GP if any risks or associations to the condition.

Many other things can cause these problems and an individual based diagnosis is best, your GP will have full medical history to be able to give you relevant information.

[helvella Administrator in reply to Stace268]

I'm confused because the AA in your image(s) - and what I thought you were asking about - relates to rs4680.

en.wikipedia.org/wiki/Rs4680

[Stace268 in reply to helvella]

😆 My lord that may explain why I get bored so easily 😐 nice link 👍

It's better than the one I found for altzeimer dementia and mitochondrial disease

[Jaydee1507 Administrator in reply to helvella]

Otherwise known as COMT gene and hers is slow which is a good thing.

[Stace268 in reply to Jaydee1507]

Why is that good? I don't have schizophrenia? 😆

[Jaydee1507 Administrator in reply to Stace268]

Actually you would need to know probaby a few other results to know how it would affect you. I think its to do with stress and how you respond to that. You could probably do a lot of reading on its effects but there are so many combinations of other genes that can affect it also.

potomacpsychiatry.com/blog/...

[Stace268 in reply to Jaydee1507]

Makes sense why my cortisol was high at one point

[Stace268 in reply to Jaydee1507]

Why is it good COMT slow?

[Jaydee1507 Administrator in reply to Stace268]

I think I was thinking of being able to tolerate certain supplements such as methyls.

This is a good read. drlamcoaching.com/blog/comp...

[Stace268 in reply to Jaydee1507]

Always knew I was different 😆.Thank you for information

[bookish in reply to Stace268]

It isn't - you really want COMT to be neither fast nor slow (AG, not slow AA or fast GG). Mine is slow and it is a problem. But one single SNP doesn't cause illness and it may not have expressed, you need to look at the whole pathway/s as interractions can get complicated. Some cannot tolerate methyl at all, some (like me) can and benefit considerably. But thanks for putting your test results on, because I'd not seen anyone make a direct link to poor thyroid function, although it makes sense because of slow catechol oestrogen metabolism. Cheers

[Stace268 in reply to bookish]

When you say methyl do you mean methylated vitamins?I think I have the MTHR gene as well as Rs225014 T>C OR Thr92Ala came up before which is linked to mitochondrial DNA apparently

[bookish in reply to Stace268]

Hi, yes I mean methylated forms of vitamins. Some do not tolerate well at all, so as usual take it slow if you decide to supplement. (But always do full B12/folate testing, preferably not just serum which is insufficient, before you take B12 or folate). As to DIO2 I can't help as never tested and have no info of use. We all have MTH(F)R, the question is how well you are actually functioning - and knowing what SNPs you have can be helpful, but again, may not have expressed and cannot be looked at in isolation. eg I only have a heterozygous SNP on C677T which shouldn't make much difference to anything but COMT and MTHFR potentially affect each other and I have other methylation/homocysteine/methionine synthase SNPs like MTR, so several small issues along the same pathways. The whole together was/is causing me some problems. You might find this interesting re MTHFR medlineplus.gov/lab-tests/m.... Cheers

[Stace268 in reply to bookish]

My mum, me and my son all have anemia. My son has been getting chest pains he is only 9. Would this test been routinely done at birth?methylation/homocysteine/methionine And I'm thinking I should get it done now for my son

[bookish in reply to Stace268]

I'm afraid it wouldn't be likely that any of them would have been considered at all and I doubt you'll get anyone to do any of them now except privately. What sort of anemia, do you all have the same?

[Stace268 in reply to bookish]

I'm not sure as only done basics checks I think on iron.I had two DNA test done and not sure I understand either

[bookish in reply to Stace268]

As I'm sure you know there are several different types of anemia. If it is iron, and all three of you, I'd be investigating absorption, particularly gluten - have you all been checked for coeliac, which is step one - gluten intolerance/NCGS is not something the NHS will look for, but you could get coeliac 'ruled out' as far as basic testing goes (it will only pick up those with significant damage, so a negative test doesn't mean you can't be coeliac but a positive will get you some help.) Any autoimmunity in the family already?

[Stace268 in reply to bookish]

No coeliac on any of us, I think its just blood type as me n son have low normal red cell distribution width is something I noticed on blood tests and I think my dad n grandad had thyroid problems as well, my dad's sister also

[bookish in reply to Stace268]

Unusual to have low RDW with a blood issue as far as I know. With low iron you usually get high RDW and low MDV, with folate (B9) and/or B12 deficiency it would show high RDW and high MCV, and with both low iron and low Bs you would be likely to show high RDW and variable MCV (can look normal as they cancel each other out).

As your COMT may well be slow, doing what you can to improve function might be worth your time. Have a look at CoeliacMum1's post link above.

[Stace268]

Graves disease test

Graves Test if suspected