Dr.sohir

[Sohir]

Please any person try to use ketocinazole to block cortisol oral or cream and tell me result

[radd]

Sohir,

An antifungal, also commonly used on dogs, whose side effects helps with Cushings.

Never heard of it, so had to google it.

Using a word associated with the subject as the title of your post, might invite further replies.

[MaisieGray in reply to radd]

radd That may be just the topical cream, the BNF describes its oral use as:

An imidazole derivative which acts as a potent inhibitor of cortisol and aldosterone synthesis by inhibiting the activity of 17α-hydroxylase, 11-hydroxylation steps and at higher doses the cholesterol side-chain cleavage enzyme.

It also inhibits the activity of adrenal C17-20 lyase enzymes resulting in androgen synthesis inhibition, and may have a direct effect on corticotropic tumour cells in patients with Cushing's disease.

[radd in reply to MaisieGray]

MaisieGray

Yes, the o/p refers to either oral or topical. Double, triple, quadruple (or a hundred times more) it’s strength and directive totally changes.