Thyroid UK

Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter

I freely admit, I did not know of Takotsubo Cardiomyopathy and had to look it up.

Takotsubo cardiomyopathy

An image of a heart from a person with Takotsubo cardiomopathy

Takotsubo cardiomyopathy, also known as Takotsubo syndrome, is a temporary condition where your heart muscle becomes suddenly weakened or ‘stunned’.

The left ventricle, one of the heart’s chambers, changes shape and enlarges. This means this part of the heart doesn’t pump well.

This condition is also called acute stress-induced cardiomyopathy, broken heart syndrome and apical ballooning syndrome.

Takotsubo cardiomyopathy was first reported in Japan in 1990. The word ’Takotsubo’ means ‘octopus pot’ in Japanese, as the left ventricle of the heart changes into a similar shape as the pot - developing a narrow neck and a round bottom.

The condition can develop at any age, but typically affects more women than men.

The good news is that often the condition is temporary and reversible.

Int J Angiol. 2016 Dec;25(5):e121-e122. doi: 10.1055/s-0035-1548548. Epub 2015 Mar 23.

Takotsubo Cardiomyopathy Associated with Primary Hyperthyroidism Secondary to Toxic Multinodular Goiter.

Murdoch D1, O'Callaghan W2, Reda E2, Niranjan S3.

Author information

1Department of Cardiology, The Prince Charles Hospital, Brisbane, Australia; School of Medicine, The University of Queensland, Brisbane, Australia.

2Department of Endocrinology, Gold Coast University Hospital, Gold Coast, Australia.

3Department of Endocrinology, Gold Coast University Hospital, Gold Coast, Australia; School of Medicine, Griffith University, Gold Coast, Australia.


Takotsubo cardiomyopathy is increasingly recognized as a distinct clinical entity. An association with thyroid disease has been identified in several case reports, mostly in the context of Grave disease. We report the case of a 67-year-old woman presenting with takotsubo cardiomyopathy and thyrotoxicosis secondary to toxic multinodular goiter. Previously unreported, this suggests that this association is related to the direct effects of thyroid hormone, rather than an autoimmune mechanism. Thyroid disease should be considered in patients presenting with takotsubo cardiomyopathy.


cardiomyopathy; hyperthyroidism; takotsubo; toxic multinodular goiter

PMID: 28031674

DOI: 10.1055/s-0035-1548548

2 Replies

I had a takotsubo in July 14 & it is indeed temp. A follow up MRI showed my heart had returned to normal months later .. hope that is reassuring 😊 Happy new year

1 like

Thank you so much for responding.

Do you feel completely recovered? Certainly hope so.

Do you know what your thyroid hormone levels were like at the time?


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