I had my thygland removed 14 years ago due to a papilliary cancerous nodule, found unexpectedly, so the whole of the gland was removed. I have been on varying doses of levo all this time, with various side effects... none of which I realised at the time, was probably due to the levo. All those years ago, I started on 150mg which over the years has steadily reduced. Now I am on 100 mcg for 5 days and 125mcg on 2 days. Until recently I was on alternate 125 and 100's. Now since the dose was decreased 6 weeks ago (only by 25mcg tho') I feel quite tired and achey now, whereas contrary to many people's experience I used to have loads of energy with a quick spurt about 10pm in the eve, when I would scrub the kitchen worsurfaces for 15 mins!!! I feeel dopey now, can that happen with such a small reduction in levo? and my legs are really sore. Roughly, for people with no thyroid what would be the optimum dosage? Thanks again for this brilliant site.