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Xtandi
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Checkpoint inhibitor therapy.
Not everyone benefited, but when
Xtandi
resistance occurs, there may be PD-L1 over-expression & a therapeutic response to a PD-L1 inhibitor. In a recent paper (2017) [6]: "We analyzed tumors from 51 patients with {lymph} node-positive prostate cancer ...
Not everyone benefited, but when
Xtandi
resistance occurs, there may be PD-L1 over-expression & a therapeutic response to a PD-L1 inhibitor. In a recent paper (2017) [6]: "We analyzed tumors from 51 patients with {lymph} node-positive prostate cancer ...
pjoshea13
in
Advanced Prostate Cancer
7 years ago
PLEASE READ THIS REQUEST
it's looking like docalutamide (currently in stage 3 trials) is going to be the NEXT drug after
Xtandi
, probably not due to be on the market until late 2018...or even 2019. Here's our problem. My husband needs it NOW. We requested a ''compassionate use'' designation.
it's looking like docalutamide (currently in stage 3 trials) is going to be the NEXT drug after
Xtandi
, probably not due to be on the market until late 2018...or even 2019. Here's our problem. My husband needs it NOW. We requested a ''compassionate use'' designation.
wifeofvet
in
Advanced Prostate Cancer
7 years ago
Zytiga
I have had 5 sessions on taxotere and now after the last chemo he is going to put me on zytiga or
xtandi
pills and said I will need to stay on them and my Lupron every 4 months. Just wondering if anyone has gone this route? My psa is down to 9 from 1400. Thanks for your help.
I have had 5 sessions on taxotere and now after the last chemo he is going to put me on zytiga or
xtandi
pills and said I will need to stay on them and my Lupron every 4 months. Just wondering if anyone has gone this route? My psa is down to 9 from 1400. Thanks for your help.
rxearl
in
Advanced Prostate Cancer
7 years ago
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Enzalutamide & drug interactions.
New Dutch paper below [1] In a recent post, I mentioned that
Xtandi
could cause the liver to metabolize more of certain drugs, thereby weakening the dose: Wiki [2]: "Enzalutamide is a moderate to strong inducer of multiple cytochrome P450 enzymes including CYP3A4, CYP2C9, and CYP2C19 and hence has a
New Dutch paper below [1] In a recent post, I mentioned that
Xtandi
could cause the liver to metabolize more of certain drugs, thereby weakening the dose: Wiki [2]: "Enzalutamide is a moderate to strong inducer of multiple cytochrome P450 enzymes including CYP3A4, CYP2C9, and CYP2C19 and hence has a
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Metformin & Xtandi Resistance.
New study below. "Although the newly developed second-generation anti-androgen drug enzalutamide can repress prostate cancer progression significantly, it only extends the survival of prostate cancer patients by 4-6 months mainly due to the occurrence of enzalutamide resistance." "We showed that metformin
New study below. "Although the newly developed second-generation anti-androgen drug enzalutamide can repress prostate cancer progression significantly, it only extends the survival of prostate cancer patients by 4-6 months mainly due to the occurrence of enzalutamide resistance." "We showed that metformin
pjoshea13
in
Advanced Prostate Cancer
7 years ago
My father will begin taking Xtandi-
My father will begin taking
Xtandi
- any personal experiences, stories to share on side effects, whatto exoect and how he might feel?
My father will begin taking
Xtandi
- any personal experiences, stories to share on side effects, whatto exoect and how he might feel?
Daddysdaughter
in
Advanced Prostate Cancer
7 years ago
Moving on from Zytiga
If I turn out to be ARV7 Neg, then we may add
Xtandi
simultaneously. I've known this would come, but I feel just a tiny bit more mortal this week. If any of you have stopped Zytiga and found a good way to use unopened bottles of the drug, please let me know.
If I turn out to be ARV7 Neg, then we may add
Xtandi
simultaneously. I've known this would come, but I feel just a tiny bit more mortal this week. If any of you have stopped Zytiga and found a good way to use unopened bottles of the drug, please let me know.
YostConner
in
Advanced Prostate Cancer
7 years ago
Xtandi and leg/foot swelling?
Hey guys, Been on
Xtandi
for over a month and it's been doing it's job and has dropped my psa, but I'm having an issue with one of my legs swelling at the calf down into my foot. Has anyone else experienced this on
Xtandi
? It lists leg swelling as a possible side effect on the
Xtandi
website.
Hey guys, Been on
Xtandi
for over a month and it's been doing it's job and has dropped my psa, but I'm having an issue with one of my legs swelling at the calf down into my foot. Has anyone else experienced this on
Xtandi
? It lists leg swelling as a possible side effect on the
Xtandi
website.
kepster
in
Advanced Prostate Cancer
7 years ago
Completed 2 rounds of chemo 8 to go. I can do this
When it went up the this last time me tried zytiga and
xtandi
. Both fail as my PSA was rapidly climbing. Well I was put on chemo (taxotere). My first round was terrible. I was as sick as you can get and experienced every side effect and more. It put me down hard for about 2 weeks but I got better.
When it went up the this last time me tried zytiga and
xtandi
. Both fail as my PSA was rapidly climbing. Well I was put on chemo (taxotere). My first round was terrible. I was as sick as you can get and experienced every side effect and more. It put me down hard for about 2 weeks but I got better.
Rexwayne
in
Advanced Prostate Cancer
7 years ago
Xtandi dosage
I am confused about the dosage of
Xtandi
, I'm sure I read some patients are taking 1 pill 4 times a day while others take 4 pills once a day. Did I read about these dosages on this site? I know what my oncologist said but I want it verified. Thank you.
I am confused about the dosage of
Xtandi
, I'm sure I read some patients are taking 1 pill 4 times a day while others take 4 pills once a day. Did I read about these dosages on this site? I know what my oncologist said but I want it verified. Thank you.
docbulldog
in
Advanced Prostate Cancer
7 years ago
Jevtana Results
I have already gone through
Xtandi
, Zytiga etc.... Your thoughts, Lou
I have already gone through
Xtandi
, Zytiga etc.... Your thoughts, Lou
LP16
in
Advanced Prostate Cancer
7 years ago
About to start Extandi
I'm about to start
Xtandi
. Planning on taking four pills at one time at bedtime with a glass of milk. Any advice on : when is the best time of day to take the four pills ? With or without food? If with, what food? Any other helpful hints?
I'm about to start
Xtandi
. Planning on taking four pills at one time at bedtime with a glass of milk. Any advice on : when is the best time of day to take the four pills ? With or without food? If with, what food? Any other helpful hints?
chascri
in
Advanced Prostate Cancer
7 years ago
I'm at the scary door labeled chemo
I have gone thru Zytiga and now
Xtandi
all while on Lupron and Exgeva. I was a gleason 8 with an initial PSA of 35. Prostate was removed in 2013 at 55yo. My previous scans showed I have 6 bone mets all centered in the pelvic and lower spine and no soft tissue involvement.
I have gone thru Zytiga and now
Xtandi
all while on Lupron and Exgeva. I was a gleason 8 with an initial PSA of 35. Prostate was removed in 2013 at 55yo. My previous scans showed I have 6 bone mets all centered in the pelvic and lower spine and no soft tissue involvement.
charmander
in
Advanced Prostate Cancer
7 years ago
Failed all gold standard treatments and both Chemos? Whats next?
Have failed all gold standard treatments, Lupron, casodex, Zytiga,
Xtandi
, Taxotere, cabazitaxel, etc. was about to start Xofigo but then was refused due to mets on the liver. My PSA is 600 now.
Have failed all gold standard treatments, Lupron, casodex, Zytiga,
Xtandi
, Taxotere, cabazitaxel, etc. was about to start Xofigo but then was refused due to mets on the liver. My PSA is 600 now.
sinjonn
in
Advanced Prostate Cancer
7 years ago
Diagnosis + 18 years; update since Xofigo
My PSA has risen to 5.35 so my medical oncologist has started me on
Xtandi
. The fetanyl patch has made controlling the pain much easier. I am still able to do my daily activities, play bocce 5 days a week, and light exercises.
My PSA has risen to 5.35 so my medical oncologist has started me on
Xtandi
. The fetanyl patch has made controlling the pain much easier. I am still able to do my daily activities, play bocce 5 days a week, and light exercises.
chascri
in
Advanced Prostate Cancer
7 years ago
Preparing for Round Two
I have appointments in September with my oncologist and two doctors at the Cancer Agency and I am guessing it won't be long before they put me on an androgen receptor inhibitory drug like
Xtandi
or Zytiga.
I have appointments in September with my oncologist and two doctors at the Cancer Agency and I am guessing it won't be long before they put me on an androgen receptor inhibitory drug like
Xtandi
or Zytiga.
RyderLake2
in
Advanced Prostate Cancer
7 years ago
Apalutamide (ARN-509) & the SPARTAN Trial.
(Apalutamide might be an improvement on
Xtandi
.) I mentioned SPARTAN 2 years ago (pasted from [1]), but no results have yet been published: "In September 2013, J&J initiated the development of a major, randomized, double-blind, Phase III clinical trial of ARN-509 (the ...
(Apalutamide might be an improvement on
Xtandi
.) I mentioned SPARTAN 2 years ago (pasted from [1]), but no results have yet been published: "In September 2013, J&J initiated the development of a major, randomized, double-blind, Phase III clinical trial of ARN-509 (the ...
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Tell Us How Xtandi is affecting you.
Astellas, the manufacturer of
Xtandi
, is looking for brand Ambassaders .... people who with hopeful stories about their use of
Xtandi
to share on national media. Those selected will be compensated, but the real value is for you to share your story on a national platform.
Astellas, the manufacturer of
Xtandi
, is looking for brand Ambassaders .... people who with hopeful stories about their use of
Xtandi
to share on national media. Those selected will be compensated, but the real value is for you to share your story on a national platform.
Darryl
Partner
in
Advanced Prostate Cancer
7 years ago
Gleason 9 (5+4) 10+ years ago - widely metastatic cancer and running out of options!
He’s considering clinical trials (now that his cancer has been let loose, so to speak), but he won’t do any chemo, Zytiga, or
Xtandi
. I appreciate advice!
He’s considering clinical trials (now that his cancer has been let loose, so to speak), but he won’t do any chemo, Zytiga, or
Xtandi
. I appreciate advice!
23casa
in
Advanced Prostate Cancer
7 years ago
AR-V7 Video.
New video for those interested/concerned about AR-V7 & Zytiga/
Xtandi
resistance. I don't know what form AR-V7 test results takes. One can have a few AR-V7 cells at diagnosis, but that shouldn't stop one from using either drug.
New video for those interested/concerned about AR-V7 & Zytiga/
Xtandi
resistance. I don't know what form AR-V7 test results takes. One can have a few AR-V7 cells at diagnosis, but that shouldn't stop one from using either drug.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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