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American Thyroid Association - Thyroid Hormone Testing overview
Like most documents, this has strengths and weaknesses. You might find it easier to follow than some. Though some of it really is quite hard for those not already familiar with thyroid issues. Or more up-to-date (it was published this year - 2024). And it might provide some useful and quotable
Like most documents, this has strengths and weaknesses. You might find it easier to follow than some. Though some of it really is quite hard for those not already familiar with thyroid issues. Or more up-to-date (it was published this year - 2024). And it might provide some useful and quotable
helvella
Thyroid UK
in
Thyroid UK
23 days ago
US-based, Prospective, Blinded Study of Thyrotropin Receptor Antibody in Autoimmune Thyroid Disease
A rather disappointing paper. First, the full paper is, as so often, behind a paywall. Also, because the the paper doesn't come out with a clear "Yes, the tests are wonderful and reliable." It is quite clear that there is sufficient uncertainty to question all results from these tests. We have had
A rather disappointing paper. First, the full paper is, as so often, behind a paywall. Also, because the the paper doesn't come out with a clear "Yes, the tests are wonderful and reliable." It is quite clear that there is sufficient uncertainty to question all results from these tests. We have had
helvella
Thyroid UK
in
Thyroid UK
28 days ago
Suspected Graves
Hi just after some help please. I have had suppressed TSH levels since 2010, apart from a blip in 2014 when it was 2 pmol/l. (range is 0.35 to 4.7. ). My level has been consistently low at 0.02 pmol/l from 2018 to 2024. My T4 has been in range over the years ( 7.8 to 21) however my T3 was raised at
Hi just after some help please. I have had suppressed TSH levels since 2010, apart from a blip in 2014 when it was 2 pmol/l. (range is 0.35 to 4.7. ). My level has been consistently low at 0.02 pmol/l from 2018 to 2024. My T4 has been in range over the years ( 7.8 to 21) however my T3 was raised at
Gutsy2
in
Thyroid UK
2 months ago
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Takotsubo syndrome outcomes predicted by thyroid hormone signature: insights from cluster analysis of a multicentre registry
Brand new paper from Johannes Dietrich (one of diogenes' group) and others. [i]
What is takotsubo cardiomyopathy?
[/i] [i]British Heart Foundation[/i] https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy [i]
Takotsubo syndrome outcomes predicted by
Brand new paper from Johannes Dietrich (one of diogenes' group) and others. [i]
What is takotsubo cardiomyopathy?
[/i] [i]British Heart Foundation[/i] https://www.bhf.org.uk/informationsupport/conditions/cardiomyopathy/takotsubo-cardiomyopathy [i]
Takotsubo syndrome outcomes predicted by
helvella
Thyroid UK
in
Thyroid UK
5 months ago
secondary hypo and doctor questioning diagnosis
Hello everyone, I moved to a new GP in the last few years (house move). When I moved, my doctor just continued prescribing levothyroxine because it was on my records and although he wasn't testing T3 he did look at T4 and seemed to listen to me when I explained the levels I needed to be at, in order
Hello everyone, I moved to a new GP in the last few years (house move). When I moved, my doctor just continued prescribing levothyroxine because it was on my records and although he wasn't testing T3 he did look at T4 and seemed to listen to me when I explained the levels I needed to be at, in order
strawberrysorbet
in
Thyroid UK
7 months ago
Preconception Thyrotropin Levels and Thyroid Function at Early Gestation in Women With Hashimoto Thyroiditis
Of course, research is necessary. We can all make lots of assumptions, guesses, which turn out to be entirely wrong. But this paper does seem to endorse what many here have said. If you are going to become pregnant, that itself will tend to raise TSH levels. If you want to keep below any chosen TSH
Of course, research is necessary. We can all make lots of assumptions, guesses, which turn out to be entirely wrong. But this paper does seem to endorse what many here have said. If you are going to become pregnant, that itself will tend to raise TSH levels. If you want to keep below any chosen TSH
helvella
Thyroid UK
in
Thyroid UK
1 year ago
Early 50s male, healthy till hypothyroidism my first few months experience of treatment
I don't usually share info on the internet, but as a lot of material out there is aimed at women or Americans (I mean no offence to either!) I thought I'd stay my experience so far. Diagnosis, what does it all mean, and treatment/first medications. DIAGNOSIS Late 2022 I saw a nurse as I was taking longer
I don't usually share info on the internet, but as a lot of material out there is aimed at women or Americans (I mean no offence to either!) I thought I'd stay my experience so far. Diagnosis, what does it all mean, and treatment/first medications. DIAGNOSIS Late 2022 I saw a nurse as I was taking longer
BobMcBob
in
Thyroid UK
1 year ago
TSH is just the 'opinion' of your Pituitary about your dose ~ but your Pituitary's 'opinion' is a bit warped once you take Thyroid Hormone.
These first two papers can be used to prove that on T4 monotherapy , a dose that is enough to 'satisfy' the hypothalamus /pituitary (ie. lowers TSH to the bottom end of the ref range) , does not necessarily provide 'enough' T3 to all the other tissues... some other tissues can remain hypothyroid despite
These first two papers can be used to prove that on T4 monotherapy , a dose that is enough to 'satisfy' the hypothalamus /pituitary (ie. lowers TSH to the bottom end of the ref range) , does not necessarily provide 'enough' T3 to all the other tissues... some other tissues can remain hypothyroid despite
tattybogle
in
Thyroid UK
1 year ago
Computer-Assisted Levothyroxine Dose Selection for the Treatment of Postoperative Hypothyroidism
A paper which causes me significant concern. This is my blog which explains, I hope, my deep scepticism about existing prediction of required levothyroxine doses. [i]
helvella - Estimation of Levothyroxine Dosing in Adults
A discussion about the use of formulas to estimate levothyroxine
A paper which causes me significant concern. This is my blog which explains, I hope, my deep scepticism about existing prediction of required levothyroxine doses. [i]
helvella - Estimation of Levothyroxine Dosing in Adults
A discussion about the use of formulas to estimate levothyroxine
helvella
Thyroid UK
in
Thyroid UK
1 year ago
[i]Causal relationship between thyroid dysfunction and hallux valgus[/i]
Hallux valgus is commonly referred to as a bunion. The paper is complex - but the take-home is that there is a genetic relationship in at least some patients between hallux valgus and hypothyroidism. Another one to add to the list... [i]Causal relationship between thyroid dysfunction and hallux
Hallux valgus is commonly referred to as a bunion. The paper is complex - but the take-home is that there is a genetic relationship in at least some patients between hallux valgus and hypothyroidism. Another one to add to the list... [i]Causal relationship between thyroid dysfunction and hallux
helvella
Thyroid UK
in
Thyroid UK
1 year ago
useful 'Evidence' that TSH between 0.04 - 0.4 has no increased risk to patients on Levothyroxine (UPDATED~new study does show small risk)
This paper forms part of the evidence base for the current NHS thyroid treatment guidelines , it was referenced as evidence to back up their concerns about "low TSH /overtreatment with levo/ risk to bones and heart" ( so they cannot say it is 'not good enough evidence' when you put it under their
This paper forms part of the evidence base for the current NHS thyroid treatment guidelines , it was referenced as evidence to back up their concerns about "low TSH /overtreatment with levo/ risk to bones and heart" ( so they cannot say it is 'not good enough evidence' when you put it under their
tattybogle
in
Thyroid UK
1 year ago
Serum Thyrotropin and Triiodothyronine Levels in Levothyroxine-Treated Patients
Comment by Bianco: [i]In LT4-treated patients (blue box=ref. FT4 range), the increase in FT4 is associated with a major drop in TSH, but the increase in blood T3 is minimal. LT4 is really good at normalizing TSH; not nearly as good at restoring T3, the active thyroid hormone.[/i] I don't think
Comment by Bianco: [i]In LT4-treated patients (blue box=ref. FT4 range), the increase in FT4 is associated with a major drop in TSH, but the increase in blood T3 is minimal. LT4 is really good at normalizing TSH; not nearly as good at restoring T3, the active thyroid hormone.[/i] I don't think
helvella
Thyroid UK
in
Thyroid UK
2 years ago
Plasma Metabolomics Reveals Systemic Metabolic Alterations of Subclinical and Clinical Hypothyroidism
This paper does what I have long been waiting for. Takes some blood, just the serum, and do a comprehensive analysis of pretty much everything they can detect in that serum. The subjects were divided into Control, Subclinical Hypothyroid and Hypothyroid groups. They found clear differences
This paper does what I have long been waiting for. Takes some blood, just the serum, and do a comprehensive analysis of pretty much everything they can detect in that serum. The subjects were divided into Control, Subclinical Hypothyroid and Hypothyroid groups. They found clear differences
helvella
Thyroid UK
in
Thyroid UK
2 years ago
TSH problems in diagnosis
This paper highlights the problems of using TSH in diagnosis. Hindawi Journal of yroid Research Volume 2019, Article ID 4106816, 8 pages https://doi.org/10.1155/2019/4106816 Review Article Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction Salman
This paper highlights the problems of using TSH in diagnosis. Hindawi Journal of yroid Research Volume 2019, Article ID 4106816, 8 pages https://doi.org/10.1155/2019/4106816 Review Article Challenges in Interpreting Thyroid Stimulating Hormone Results in the Diagnosis of Thyroid Dysfunction Salman
diogenes
in
Thyroid UK
2 years ago
Gluten-free diet and vitamin D uptake in patients with Hashimoto disease
This paper demonstrates that gluten-free diets with Hashimoto's may have an influence on vitamin D uptake. Just a thing to be aware of. Gluten-free diet attenuates the impact of exogenous vitamin D on thyroid autoimmunity in young women with autoimmune thyroiditis: a pilot study October 2022
This paper demonstrates that gluten-free diets with Hashimoto's may have an influence on vitamin D uptake. Just a thing to be aware of. Gluten-free diet attenuates the impact of exogenous vitamin D on thyroid autoimmunity in young women with autoimmune thyroiditis: a pilot study October 2022
diogenes
in
Thyroid UK
2 years ago
Yet another definitive paper on relation between FT4 and TSH
This paper brings together my collaborator Prof Hoermann and a similar group in Australia who have been studying the phenomena in parallel with us. It shows that TSH and FT4 are linked, but there is no correct way of measuring sensitivity of TSH. In this it brings our two groups together (not without
This paper brings together my collaborator Prof Hoermann and a similar group in Australia who have been studying the phenomena in parallel with us. It shows that TSH and FT4 are linked, but there is no correct way of measuring sensitivity of TSH. In this it brings our two groups together (not without
diogenes
in
Thyroid UK
2 years ago
Pregnancy and thyroid function
The rate of relevant publication is getting fiercer and fiercer. This August publication discusses the superior measurement of FT4 in pregnancy rather than TSH. The whole paper is available. I append the abstract here. Note the claim of superiority in diagnosis using FT4 over TSH. The application
The rate of relevant publication is getting fiercer and fiercer. This August publication discusses the superior measurement of FT4 in pregnancy rather than TSH. The whole paper is available. I append the abstract here. Note the claim of superiority in diagnosis using FT4 over TSH. The application
diogenes
in
Thyroid UK
2 years ago
Hypothyroidism in pregnancy
This paper examines the relationships between TSH and FT4 as diagnostics in pregnancy (behind a paywall ). No FT3 done. Hypothyroid symptoms throughout pregnancy are predominantly associated with thyroxine and not with thyrotropin concentrations August 2022 Thyroid DOI: 10.1089
This paper examines the relationships between TSH and FT4 as diagnostics in pregnancy (behind a paywall ). No FT3 done. Hypothyroid symptoms throughout pregnancy are predominantly associated with thyroxine and not with thyrotropin concentrations August 2022 Thyroid DOI: 10.1089
diogenes
in
Thyroid UK
2 years ago
A recent review of the failings of the currently held model for thyroid treatment
I don't think I've already posted this. This review again sets out the failings of the TSH-T4 dominated model of thyroid therapy and treatment. Open to download Endocrine https://doi.org/10.1007/s12020-021-02851-6 VIEWPOINT Thyroid testing paradigm switch from thyrotropin to thyroidhormones—Future
I don't think I've already posted this. This review again sets out the failings of the TSH-T4 dominated model of thyroid therapy and treatment. Open to download Endocrine https://doi.org/10.1007/s12020-021-02851-6 VIEWPOINT Thyroid testing paradigm switch from thyrotropin to thyroidhormones—Future
diogenes
in
Thyroid UK
2 years ago
Inappropriate TSH syndrome
This Argentinian paper discuss the etiology of the inappropriate TSH syndrome and discusses its origins. Unfortunately no doi number but you can find it using the journal volume and page.
REVISIÓN
Revista Argentina de Endocrinología y MetabolismoCopyright
This Argentinian paper discuss the etiology of the inappropriate TSH syndrome and discusses its origins. Unfortunately no doi number but you can find it using the journal volume and page.
REVISIÓN
Revista Argentina de Endocrinología y MetabolismoCopyright
diogenes
in
Thyroid UK
2 years ago
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