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Myelofibrosis
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Pelabresib in Combination With Ruxolitinib for Myelofibrosis
This combination has the potential to improve the standard of care for treatment-naïve patients with
myelofibrosis
and warrants further investigation.
This combination has the potential to improve the standard of care for treatment-naïve patients with
myelofibrosis
and warrants further investigation.
Manouche
in
MPN Voice
1 year ago
Besremi clinical trial opportunity
I've was diagnosed with Jak2+ ET in March, though the BMB report stated they couldn't exclude pre-fibrotic
myelofibrosis
as a possible differential. It's been a bit of a crazy ride, but am now under the care of an MPN specialist (what a difference a specialist makes!)
I've was diagnosed with Jak2+ ET in March, though the BMB report stated they couldn't exclude pre-fibrotic
myelofibrosis
as a possible differential. It's been a bit of a crazy ride, but am now under the care of an MPN specialist (what a difference a specialist makes!)
WRLM
in
MPN Voice
8 months ago
FDA Issues Complete Response Letter for Ruxolitinib Extended-Release Tablets
Ruxolitinib, a Janus kinas (JAK)1/JAK2 inhibitor, is currently marketed under the brand name Jakafi for the treatment of
myelofibrosis
, polycythemia vera, and GVHD. Jakafi is supplied in 5mg, 10mg, 15mg, 20mg, and 25mg tablets.
Ruxolitinib, a Janus kinas (JAK)1/JAK2 inhibitor, is currently marketed under the brand name Jakafi for the treatment of
myelofibrosis
, polycythemia vera, and GVHD. Jakafi is supplied in 5mg, 10mg, 15mg, 20mg, and 25mg tablets.
PhysAssist
in
MPN Voice
1 year ago
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Ruxolitinib/Pegylated Interferon Alpha 2a Reduces Spleen Length in Myelofibrosis
decrease and potential eradication of hematopoietic stem cells » https://www.onclive.com/view/ruxolitinib-pegylated-interferon-alpha-2a-reduces-spleen-length-in-
myelofibrosis
decrease and potential eradication of hematopoietic stem cells » https://www.onclive.com/view/ruxolitinib-pegylated-interferon-alpha-2a-reduces-spleen-length-in-
myelofibrosis
Manouche
in
MPN Voice
1 year ago
New MF drugs in development by Incye
So in terms of mutant CALR it's about 25% to 30% of
myelofibrosis
and ET. It's a neoantigen that's expressed and the antibody targets that and could eradicate the clone.
So in terms of mutant CALR it's about 25% to 30% of
myelofibrosis
and ET. It's a neoantigen that's expressed and the antibody targets that and could eradicate the clone.
CanadaG
in
MPN Voice
8 months ago
update
To cut a long story short he is adding MDS to my
myelofibrosis
diagnosis in order to access both drugs (ruxolitinib and Azacitidine) which have been researched to act together better than either individually as soon as I’ve had the surgery to replace my port - scheduled for June 13 th So a result.
To cut a long story short he is adding MDS to my
myelofibrosis
diagnosis in order to access both drugs (ruxolitinib and Azacitidine) which have been researched to act together better than either individually as soon as I’ve had the surgery to replace my port - scheduled for June 13 th So a result.
beetle
in
MPN Voice
1 year ago
Managing Life With an MPN | What You Need to Know
Raajit Rampal, an MPN specialist, will share advice for making treatment decisions for patients with essential thrombocythemia (ET), polycythemia vera (PV), and
myelofibrosis
(MF). Dr.
Raajit Rampal, an MPN specialist, will share advice for making treatment decisions for patients with essential thrombocythemia (ET), polycythemia vera (PV), and
myelofibrosis
(MF). Dr.
hunter5582
in
MPN Voice
1 year ago
Royal Marsden Hospital Sutton - anyone else being treated there?
Hi I have primary
myelofibrosis
, still on rux 15 mg twice a day. Don’t seem to qualify for any of the other meds, 🙁 and I’m getting by with blood transfusions every month or so. Intervals irregular. .
Hi I have primary
myelofibrosis
, still on rux 15 mg twice a day. Don’t seem to qualify for any of the other meds, 🙁 and I’m getting by with blood transfusions every month or so. Intervals irregular. .
Gipsy123
in
MPN Voice
1 year ago
Travel Insurance
I have
myelofibrosis
and was insured the last couple of years on a family worldwide multi trip insurance but am struggling to get any this year for some reason. The company I was with last year can insure me again but it’s double the cost.
I have
myelofibrosis
and was insured the last couple of years on a family worldwide multi trip insurance but am struggling to get any this year for some reason. The company I was with last year can insure me again but it’s double the cost.
ajdolly
in
MPN Voice
1 year ago
Really??: Pruritus May Mark Severe Symptomology in Myeloproliferative Neoplasms"- From "Hematology Advisor"- Some surprising findings...
Participants had a median age of 68.6 years, 56.5% were women, 54.4% had essential thrombocythemia (ET), 37.7% had polycythemia vera (PV), and 7.9% primary
myelofibrosis
(PMF). Most participants (77.4%) had Janus activated kinase 2 (JAK2)-mutated disease.
Participants had a median age of 68.6 years, 56.5% were women, 54.4% had essential thrombocythemia (ET), 37.7% had polycythemia vera (PV), and 7.9% primary
myelofibrosis
(PMF). Most participants (77.4%) had Janus activated kinase 2 (JAK2)-mutated disease.
PhysAssist
in
MPN Voice
1 year ago
Just a vent post. And future anxiety
As a person who is a medicine and surgery graduate and for better understanding of the disease i have asked around quite a bit, especially to people who have had longer periods of
myelofibrosis
free years, and it did seem like a symptomatic disease especially pruritus seemed to be almost absent in those
As a person who is a medicine and surgery graduate and for better understanding of the disease i have asked around quite a bit, especially to people who have had longer periods of
myelofibrosis
free years, and it did seem like a symptomatic disease especially pruritus seemed to be almost absent in those
Xuzy
in
MPN Voice
1 year ago
INCA033989 phase 1 clinical trial is recruiting patients
www.rarediseaseadvisor.com/news/mf-news-briefs/phase-1-trial-testing-potential-mf-therapy-recruiting/[/i] A new phase 1 clinical trial evaluating the safety, tolerability, and dose limiting toxicity of INCA033989 as a monotherapy or in combination with ruxolitinib in patients with myeloproliferative neoplasms including
myelofibrosis
www.rarediseaseadvisor.com/news/mf-news-briefs/phase-1-trial-testing-potential-mf-therapy-recruiting/[/i] A new phase 1 clinical trial evaluating the safety, tolerability, and dose limiting toxicity of INCA033989 as a monotherapy or in combination with ruxolitinib in patients with myeloproliferative neoplasms including
myelofibrosis
flamboyant_hawking
in
MPN Voice
1 year ago
myelofibrosis
I'm really really struggling with my new diagnosis of mf and the watch and wait approach,I am continually tired with no energy, what do others do to overcome this. Thank you.
I'm really really struggling with my new diagnosis of mf and the watch and wait approach,I am continually tired with no energy, what do others do to overcome this. Thank you.
glyndale
in
MPN Voice
2 years ago
Myelofibrosis
I have been on 90mcg weekly for about 2 years but have been told my dose may have to go up to 135mcg because my allele burden Is going up and my spleen has enlarged a bit. Does anyone have experience of more severe side effects from this higher weekly dose? I have MF .I had hoped that perhaps a bit
I have been on 90mcg weekly for about 2 years but have been told my dose may have to go up to 135mcg because my allele burden Is going up and my spleen has enlarged a bit. Does anyone have experience of more severe side effects from this higher weekly dose? I have MF .I had hoped that perhaps a bit
caroline_284
in
MPN Voice
2 years ago
Bone marrow edema not healing
Hi, Recently diagnosed with JAK2+ ET / possible pre-fibrotic
myelofibrosis
a month or so ago. Platelets have been consistently high since 2015, so I suspect I’ve gone undiagnosed for awhile. I broke my left foot late 2020.
Hi, Recently diagnosed with JAK2+ ET / possible pre-fibrotic
myelofibrosis
a month or so ago. Platelets have been consistently high since 2015, so I suspect I’ve gone undiagnosed for awhile. I broke my left foot late 2020.
WRLM
in
MPN Voice
1 year ago
myelofibrosis
Is anyone else here on" watch and wait ", am a bit unsure why treatment isn't started,forgot to ask my consultant cos I wasn't thinking straight.
Is anyone else here on" watch and wait ", am a bit unsure why treatment isn't started,forgot to ask my consultant cos I wasn't thinking straight.
glyndale
in
MPN Voice
2 years ago
myelofibrosis
Thank you everyone for your replies, advice,and links to further information, I am most concerned about the prognosis which differs depending what site you are on ,very confusing.
Thank you everyone for your replies, advice,and links to further information, I am most concerned about the prognosis which differs depending what site you are on ,very confusing.
glyndale
in
MPN Voice
2 years ago
myelofibrosis
Does anyone on here know if mf should always be treated,main symptom is fatigue, slightly enlarged spleen and slight anaemia ( for 3 years)not sure about the watch and wait approach.
Does anyone on here know if mf should always be treated,main symptom is fatigue, slightly enlarged spleen and slight anaemia ( for 3 years)not sure about the watch and wait approach.
glyndale
in
MPN Voice
2 years ago
myelofibrosis
well my et has progressed to mf,platelets normal ,wcc normal, hb slightly low spleen slightly enlarged, main symptom is fatigue. my score is low intermediate so just continue with aspirin and repeat bloods in 3 months.not sure how I feel about it all .
well my et has progressed to mf,platelets normal ,wcc normal, hb slightly low spleen slightly enlarged, main symptom is fatigue. my score is low intermediate so just continue with aspirin and repeat bloods in 3 months.not sure how I feel about it all .
glyndale
in
MPN Voice
2 years ago
myelofibrosis
Anyone diagnosed with mf and what are the main symptoms .Thanks.
Anyone diagnosed with mf and what are the main symptoms .Thanks.
glyndale
in
MPN Voice
2 years ago
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