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A good description of a mis-folded Protein that causes PD
Live-cell microscopy revealed the highly dynamic nature of the αS inclusions: for example, their rapid clearance by certain known modulators of αS toxicity, including tacrolimus (FK506),
isradipine
, nilotinib, nortriptyline, and trifluoperazine.
Live-cell microscopy revealed the highly dynamic nature of the αS inclusions: for example, their rapid clearance by certain known modulators of αS toxicity, including tacrolimus (FK506),
isradipine
, nilotinib, nortriptyline, and trifluoperazine.
Sapeye2020
in
Cure Parkinson's
2 years ago
Isradipine plasma pharmacokinetics and exposure–response in early Parkinson’s
The findings suggest that "clinically attainable brain exposure to
isradipine
may slow early-stage Parkinsons progression" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951102/
The findings suggest that "clinically attainable brain exposure to
isradipine
may slow early-stage Parkinsons progression" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7951102/
Farooqji
in
Cure Parkinson's
3 years ago
Clinical Trial Highlights – an update on previously reviewed trials (Phase 3 in focus)
STEADY-PD III was a Phase 3, parallel group, placebo-controlled 36 months study evaluating the efficacy of
isradipine
10mg daily as a disease modifying agent in early PD. The primary outcome looked at change in ON state UPDRS I-III from baseline to 36 months.
STEADY-PD III was a Phase 3, parallel group, placebo-controlled 36 months study evaluating the efficacy of
isradipine
10mg daily as a disease modifying agent in early PD. The primary outcome looked at change in ON state UPDRS I-III from baseline to 36 months.
Hidden
in
Cure Parkinson's
3 years ago
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Bummer. Isradipine fails in Phase III Trial.
Long-term use of blood pressure medication Dynacirc (
isradipine
) does not slow disease progression in people with early Parkinson’s disease, according to findings from a Phase 3 clinical trial. https://parkinsonsnewstoday.com/2020/04/02/blood-pressure-medication-dynacirc-falls-short-phase-3-trial/
Long-term use of blood pressure medication Dynacirc (
isradipine
) does not slow disease progression in people with early Parkinson’s disease, according to findings from a Phase 3 clinical trial. https://parkinsonsnewstoday.com/2020/04/02/blood-pressure-medication-dynacirc-falls-short-phase-3-trial/
jimcaster
in
Cure Parkinson's
4 years ago
Isradipine results
https://www.aan.com/PressRoom/Home/PressRelease/2720 Disappointing...
https://www.aan.com/PressRoom/Home/PressRelease/2720 Disappointing...
ParlePark
in
Cure Parkinson's
5 years ago
Isradipine calcium phase 3 clinical trial: slow PD progression?
An ongoing, NIH sponsored, Phase 3 clinical trial in North America is testing the ability of one member of the dihydropyridine class (
isradipine
) to slow PD progression in early stage patients. The review summarizes the rationale for the trial and outlines some unanswered questions.
An ongoing, NIH sponsored, Phase 3 clinical trial in North America is testing the ability of one member of the dihydropyridine class (
isradipine
) to slow PD progression in early stage patients. The review summarizes the rationale for the trial and outlines some unanswered questions.
aspergerian13
in
Cure Parkinson's
5 years ago
Isradipine trial failed - BP drug does not improve Parkinson’s
https://www.healio.com/internal-medicine/neurology/news/online/%7B73b5dd3b-660f-4ef9-af18-c40dc1bcba44%7D/bp-drug-does-not-improve-parkinsons
https://www.healio.com/internal-medicine/neurology/news/online/%7B73b5dd3b-660f-4ef9-af18-c40dc1bcba44%7D/bp-drug-does-not-improve-parkinsons
Farooqji
in
Cure Parkinson's
5 years ago
Off label medication - how to choose
He didn't know what the DATscan showed, hadn't heard of
Isradipine
, and referred me to a neurologist appointment (back in June - appointment January 23rd. I just tried to change it, and next available is June 2019.
He didn't know what the DATscan showed, hadn't heard of
Isradipine
, and referred me to a neurologist appointment (back in June - appointment January 23rd. I just tried to change it, and next available is June 2019.
WinnieThePoo
in
Cure Parkinson's
6 years ago
Why I want to research active microbiome therapies for Parkinsons
Isradipine
, I can cheat. I have (borderline) hypertension and my UK GP had me on Amlodopine which I blamed for DIP before the DATscan confirmed true (quite advanced) PD. I stopped taking Amlodopine, but my French GP is prepared to prescribe
Isradipine
.
Isradipine
, I can cheat. I have (borderline) hypertension and my UK GP had me on Amlodopine which I blamed for DIP before the DATscan confirmed true (quite advanced) PD. I stopped taking Amlodopine, but my French GP is prepared to prescribe
Isradipine
.
WinnieThePoo
in
Cure Parkinson's
6 years ago
Phase 3 Isradipine Results Coming Soon
Results will be out 3 to 6 months later and it may be the first readily available drug shown to delay progression in PD. https://parkinsonsdisease.net/research/
isradipine
/
Results will be out 3 to 6 months later and it may be the first readily available drug shown to delay progression in PD. https://parkinsonsdisease.net/research/
isradipine
/
jimcaster
in
Cure Parkinson's
6 years ago
REVIEW ARTICLE: Drug Repurposing in Parkinson's Disease (31 July 2018)
Drugs covered in this review article: Ambroxol,
Isradipine
, Inosine, UDCA, Deferiprone, Exenatide, Nilotinib, Simvastatin. https://link.springer.com/epdf/10.1007/s40263-018-0548-y?
Drugs covered in this review article: Ambroxol,
Isradipine
, Inosine, UDCA, Deferiprone, Exenatide, Nilotinib, Simvastatin. https://link.springer.com/epdf/10.1007/s40263-018-0548-y?
jeffreyn
in
Cure Parkinson's
6 years ago
Why progress is so slow in finding a solution to Parkinson's Disease
shorter time, less risk, less cost, side effects known, rapidly explored hypothesis Anti-diabetics: glitazones, exenatide Cholesterol lowering drugs: simvastin Anti-hypertensives:
isradipine
Anti-cancer drugs:
shorter time, less risk, less cost, side effects known, rapidly explored hypothesis Anti-diabetics: glitazones, exenatide Cholesterol lowering drugs: simvastin Anti-hypertensives:
isradipine
Anti-cancer drugs:
FMundo
in
Cure Parkinson's
6 years ago
Isradipine and PD
Anyone taking
Isradipine
and if so has it helped you?
Anyone taking
Isradipine
and if so has it helped you?
mroll
in
Cure Parkinson's
6 years ago
Disease Modification in Parkinson's Disease: Current Approaches, Challenges, and Future Considerations. (Wiley Online Library)
"Beyond the current phase 2 or 3 studies underway evaluating treatments directed at oxidative stress (inosine), cytosolic Ca2+ (
isradipine
), iron (deferiprone), and extracellular α‐synuclein (passive immunization), and upcoming trials of interventions affecting c‐Abl, glucagon‐like peptide‐1, and glucocerebrosidase
"Beyond the current phase 2 or 3 studies underway evaluating treatments directed at oxidative stress (inosine), cytosolic Ca2+ (
isradipine
), iron (deferiprone), and extracellular α‐synuclein (passive immunization), and upcoming trials of interventions affecting c‐Abl, glucagon‐like peptide‐1, and glucocerebrosidase
MBAnderson
in
Cure Parkinson's
6 years ago
Stomach Issues
Take Neupro and Azilect
Isradipine
Lisinipril as well. Advice anyone?
Take Neupro and Azilect
Isradipine
Lisinipril as well. Advice anyone?
Ruffinglgo
in
Cure Parkinson's
6 years ago
Caffeine and Azilect generic and other
Neupro 4mg patch and BP meds Lisinipril 5mg
Isradipine
5 mg and anxiety pill Lexapro generic 5 mg (also increases serotonin levels)Blood pressure jumped after taking Rasagiline and I was so hyper felt like my legs would March in place without me and the right leg wanted to get ahead tingling sensation
Neupro 4mg patch and BP meds Lisinipril 5mg
Isradipine
5 mg and anxiety pill Lexapro generic 5 mg (also increases serotonin levels)Blood pressure jumped after taking Rasagiline and I was so hyper felt like my legs would March in place without me and the right leg wanted to get ahead tingling sensation
Ruffinglgo
in
Cure Parkinson's
7 years ago
Over medicated?
Also, I am in a blind clinical trial, and may be taking
isradipine
10 mg twice a day (I don't know if it's that or a placebo). Does it seem as if I am overmedicated for the extent of my symptoms?
Also, I am in a blind clinical trial, and may be taking
isradipine
10 mg twice a day (I don't know if it's that or a placebo). Does it seem as if I am overmedicated for the extent of my symptoms?
S70AWD
in
Cure Parkinson's
7 years ago
Importance of publishing results of Clinical Trials
AAV2-hAADC Ambroxol AZD3241 BIIB054 CDNF 18 Exenatide (Diabetes Drug) Fucoidan GM608 Inosine
Isradipine
LDN (Low Dose Naltrexone) LRRK2 Mannitol MSDC-0160 (Diabetes Treatment) NAC Neurturin Nilotinib Nicotine NPT200-11 NRF2 Opicaone OXB-102 PRX002 Ursodiol Uridine Vatiquinone
AAV2-hAADC Ambroxol AZD3241 BIIB054 CDNF 18 Exenatide (Diabetes Drug) Fucoidan GM608 Inosine
Isradipine
LDN (Low Dose Naltrexone) LRRK2 Mannitol MSDC-0160 (Diabetes Treatment) NAC Neurturin Nilotinib Nicotine NPT200-11 NRF2 Opicaone OXB-102 PRX002 Ursodiol Uridine Vatiquinone
FMundo
in
Understanding Clinical Trials
7 years ago
What's in the PD Clinical Trial Pipeline?
In addition, a few others — for example,
isradipine
— have been used for years to treat other health conditions and supplements such as NAC and inosine. Does anyone have experience with any of these Phase I / II trials? Phase I: AAV2-GDNF.
In addition, a few others — for example,
isradipine
— have been used for years to treat other health conditions and supplements such as NAC and inosine. Does anyone have experience with any of these Phase I / II trials? Phase I: AAV2-GDNF.
p-oui
in
Cure Parkinson's
7 years ago
ISRAPIDINE IN STAGE III CLINICAL TRIALS AFTER SHOWING PROMISING RESULTS IN SLOWING PD. ANYONE INVOLVED IN THESE TRIALS?
record-pace-of-recruitment-speeds-
isradipine
-trial
record-pace-of-recruitment-speeds-
isradipine
-trial
p-oui
in
Cure Parkinson's
8 years ago
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