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TP53 Outperforms Other Androgen Receptor Biomarkers to Predict Outcomes With Abiraterone or Enzalutamide in mCRPC
The authors of this study evaluated outcomes in 168 men with mCRPC prior to treatment with androgen receptor signaling inhibitors (abiraterone,
enzalutamide
).
The authors of this study evaluated outcomes in 168 men with mCRPC prior to treatment with androgen receptor signaling inhibitors (abiraterone,
enzalutamide
).
tango65
in
Advanced Prostate Cancer
5 years ago
Re-sensitizing Zytiga and Xtandi
It seems that Niclosamide also has the potential to re-sensitize both
enzalutamide
(Xtandi) and abiraterone acetate (Zytiga). A few find that Zytiga and Xtandi doesn't work for them which is often due to the presence of the splice variant AR-V7.
It seems that Niclosamide also has the potential to re-sensitize both
enzalutamide
(Xtandi) and abiraterone acetate (Zytiga). A few find that Zytiga and Xtandi doesn't work for them which is often due to the presence of the splice variant AR-V7.
Terje
in
Advanced Prostate Cancer
5 years ago
Adding Casodex (Bicalutamide) a good idea ?
I’ve read that it was a predecessor to
Enzalutamide
but not as effective as E. Would taking it now mean that
Enzalutamide
would be out as an option later? Would taking it reduce the effectiveness of Abiraterone? Any wise thoughts from the experts in this community would be most appreciated.
I’ve read that it was a predecessor to
Enzalutamide
but not as effective as E. Would taking it now mean that
Enzalutamide
would be out as an option later? Would taking it reduce the effectiveness of Abiraterone? Any wise thoughts from the experts in this community would be most appreciated.
hansjd
in
Advanced Prostate Cancer
5 years ago
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Enzalutamide & Abiraterone ... higher T = more favorable prognosis.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in
Enzalutamide
- and Abiraterone-Treated Castration-Resistant Prostate Cancer.
Higher Serum Testosterone Levels Associated with Favorable Prognosis in
Enzalutamide
- and Abiraterone-Treated Castration-Resistant Prostate Cancer.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
U.K. news - Enzalutamide (Xtandi)
"
Enzalutamide
(Xtandi) is a type of hormone therapy that is already given to some people with prostate cancer that has spread to other parts of the body.
"
Enzalutamide
(Xtandi) is a type of hormone therapy that is already given to some people with prostate cancer that has spread to other parts of the body.
pjoshea13
in
Advanced Prostate Cancer
5 years ago
AR-V7 and Circulating Tumor Cell DNA Testing - Availability and Use
The detection of AR-V7 in the nucleus is associated with a reduced response to abiraterone and
enzalutamide
and better response to chemotherapy such as docetaxel and cabazitaxel.
The detection of AR-V7 in the nucleus is associated with a reduced response to abiraterone and
enzalutamide
and better response to chemotherapy such as docetaxel and cabazitaxel.
PhilipSZacarias
in
Advanced Prostate Cancer
5 years ago
Androgen Receptor Splice Variant 7 and Hormone Therapy Resistance in High-Risk Castration-Resistant Prostate Cancer
RESULTS We enrolled 118 men with mCRPC who were starting abiraterone or
enzalutamide
treatment.
RESULTS We enrolled 118 men with mCRPC who were starting abiraterone or
enzalutamide
treatment.
Balsam01
in
Advanced Prostate Cancer
5 years ago
Integrating Novel Targets and Precision Medicine Into Prostate Cancer Care—Part 1: The Non-Androgen–Targetable Pathways in Castration-Resist
As reported, a phase III trial of atezolizumab and
enzalutamide
vs
enzalutamide
is also underway (NCT03016312).
As reported, a phase III trial of atezolizumab and
enzalutamide
vs
enzalutamide
is also underway (NCT03016312).
JLS1
in
Advanced Prostate Cancer
5 years ago
Clinical Trial Trials
My concern is that if his PSA is rising while on Lupron and
Enzalutamide
/Placebo, that he may be becoming castrate resistant. Thought?
My concern is that if his PSA is rising while on Lupron and
Enzalutamide
/Placebo, that he may be becoming castrate resistant. Thought?
COG1
in
Advanced Prostate Cancer
6 years ago
Current Understanding of Resistance to Abiraterone and Enzalutamide in Advanced PCa
Mentions 14 ongoing clinical trials, including this: "Another approach that we have begun to test here at Johns Hopkins is the use of high-dose testosterone in patients with CRPC that has become resistant to abiraterone or
enzalutamide
(NCT02090114).
Mentions 14 ongoing clinical trials, including this: "Another approach that we have begun to test here at Johns Hopkins is the use of high-dose testosterone in patients with CRPC that has become resistant to abiraterone or
enzalutamide
(NCT02090114).
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Intense ADT before prostatectomy.
Patients were randomly assigned 2:1 to ELAP {
enzalutamide
and leuprolide with abiraterone + prednisone} or EL {
enzalutamide
and leuprolide} for 24 weeks followed by RP {radical prostatectomy}."
Patients were randomly assigned 2:1 to ELAP {
enzalutamide
and leuprolide with abiraterone + prednisone} or EL {
enzalutamide
and leuprolide} for 24 weeks followed by RP {radical prostatectomy}."
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Lu-177 "Vision" trial NCT03511664 Protocols
Novel androgen axis drugs [NAADs] (such as abiraterone or
enzalutamide
) are allowed." " COSTS "Lu-PSMA will be provided free of charge in this study to you. The administration of the radionucleotide will be billed to your insurance company.
Novel androgen axis drugs [NAADs] (such as abiraterone or
enzalutamide
) are allowed." " COSTS "Lu-PSMA will be provided free of charge in this study to you. The administration of the radionucleotide will be billed to your insurance company.
Fairwind
in
Advanced Prostate Cancer
5 years ago
Adenocarninoma with neuroendocrine differentiation
He has had first line hormone therapy, 10 sessions of docetaxel, and
enzalutamide
for 2 years. In January he had a procedure to remove some of the prostate tumour that was pushing in to the bladder making it difficult to urinate).
He has had first line hormone therapy, 10 sessions of docetaxel, and
enzalutamide
for 2 years. In January he had a procedure to remove some of the prostate tumour that was pushing in to the bladder making it difficult to urinate).
Ssiddy
in
Advanced Prostate Cancer
6 years ago
Might Enzalutamide [Xtandi] sensitize PCa to radiation?
CONCLUSIONS: These results provide evidence that the
enzalutamide
/radiotherapy combination could maximize therapeutic responses in patients with
enzalutamide
-sensitive prostate cancer.
CONCLUSIONS: These results provide evidence that the
enzalutamide
/radiotherapy combination could maximize therapeutic responses in patients with
enzalutamide
-sensitive prostate cancer.
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Patient-Reported Outcomes Following Enzalutamide or Placebo in Men With Nonmetastatic, Castration-Resistant Prostate Cancer
FINDINGS Between Nov 26, 2013, and June 28, 2017, 1401 patients were enrolled and randomly assigned to receive
enzalutamide
(n=933) or placebo (n=468). Median follow-up was 18·5 months (IQR 10·7-29·2) in the
enzalutamide
group and 15·1 months (7·4-25·9) in the placebo group.
FINDINGS Between Nov 26, 2013, and June 28, 2017, 1401 patients were enrolled and randomly assigned to receive
enzalutamide
(n=933) or placebo (n=468). Median follow-up was 18·5 months (IQR 10·7-29·2) in the
enzalutamide
group and 15·1 months (7·4-25·9) in the placebo group.
Balsam01
in
Advanced Prostate Cancer
6 years ago
My Story
Also another patient told me that abiretherone had better results than
enzalutamide
but I was offered no advice, only told to choose one or the other. I am an NHS patient so not sure they would allow me to have abiretherone having made my choice.
Also another patient told me that abiretherone had better results than
enzalutamide
but I was offered no advice, only told to choose one or the other. I am an NHS patient so not sure they would allow me to have abiretherone having made my choice.
ellyras
in
Advanced Prostate Cancer
6 years ago
Latest outcome from Lu177 treatments
To make the next and last treatment more effective, I docs put me on Xtandi,
enzalutamide
because it makes the tumours express more PsMa avidity so that more Lu177 gathers where the Pca is active. I welcome their expertise to supercharge the Lu177. So far, no side effects from Enza Lootamide.
To make the next and last treatment more effective, I docs put me on Xtandi,
enzalutamide
because it makes the tumours express more PsMa avidity so that more Lu177 gathers where the Pca is active. I welcome their expertise to supercharge the Lu177. So far, no side effects from Enza Lootamide.
Patrick-Turner
in
Advanced Prostate Cancer
5 years ago
Two new advanced hormonal agents (apalutamide and enzalutamide) increase survival in metastatic hormone sensitive prostate cancer (mHSPC)
New indications for 2 previously approved drugs - Erleada and Xtandi. I don't have all the details yet on Xtandi, but it is clearly successful for mHSPC. I'll update after the ASCO meeting. Here's what I know so far: https://pcnrv.blogspot.com/2019/05/two-new-advanced-hormonal-agents.html
New indications for 2 previously approved drugs - Erleada and Xtandi. I don't have all the details yet on Xtandi, but it is clearly successful for mHSPC. I'll update after the ASCO meeting. Here's what I know so far: https://pcnrv.blogspot.com/2019/05/two-new-advanced-hormonal-agents.html
Tall_Allen
in
Advanced Prostate Cancer
5 years ago
Looking to purchase Xtandi (Enzalutamide)
Anyone selling Xtandi?
Anyone selling Xtandi?
Frank_M
in
Advanced Prostate Cancer
5 years ago
asking for members' input
For those in favor, any opinions on abi v
enzalutamide
? I know on paper he has responded well to treatment thus far. My dad and I want to be aggressive, and it seems to make sense to continue attacking the sucker from another angle while it is weak. Thanks.
For those in favor, any opinions on abi v
enzalutamide
? I know on paper he has responded well to treatment thus far. My dad and I want to be aggressive, and it seems to make sense to continue attacking the sucker from another angle while it is weak. Thanks.
mediocra
in
Advanced Prostate Cancer
6 years ago
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