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Enzalutamide
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Advanced AR drugs
1.ADT and apalutamide (Erleada) TITAN RCT a.https://www.nejm.org/doi/full/10.1056/nejmoa1903307#:~:text=The%20TITAN%20trial%20was%20a,this%20article%20at%20NEJM.org. 2.ADT and
enzalutamide
(Xtandi) ARCHES RCT a.https://www.cancertherapyadvisor.com/home/news/conference-coverage/esmo-2021/prostate-cancer-
enzalutamide
-adt-prolongs-survival-treatment
1.ADT and apalutamide (Erleada) TITAN RCT a.https://www.nejm.org/doi/full/10.1056/nejmoa1903307#:~:text=The%20TITAN%20trial%20was%20a,this%20article%20at%20NEJM.org. 2.ADT and
enzalutamide
(Xtandi) ARCHES RCT a.https://www.cancertherapyadvisor.com/home/news/conference-coverage/esmo-2021/prostate-cancer-
enzalutamide
-adt-prolongs-survival-treatment
Hidden
in
Advanced Prostate Cancer
2 years ago
Pluvicto plus Xtandi
At the beginning of June I started
Enzalutamide
(Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness. On July 7 I called my doc and stopped taking Xtandi and I started feeling better a few days later.
At the beginning of June I started
Enzalutamide
(Xtandi) 4x40 mg. After about a month I started having issues with fatigue, loss of appetite, nausea and dizziness. On July 7 I called my doc and stopped taking Xtandi and I started feeling better a few days later.
Rondief
in
Advanced Prostate Cancer
2 years ago
Trying to avoid the sense that I am on a downward slope
When this failed, about two months ago, I was placed on a strong dose of Xtandi (
enzalutamide
), and the side effects began to pile up. The confusion deepened, and was joined by fatigue, while physical side effects built up too -- fluid retention, aching joints and muscles, tender teeth (!)
When this failed, about two months ago, I was placed on a strong dose of Xtandi (
enzalutamide
), and the side effects began to pile up. The confusion deepened, and was joined by fatigue, while physical side effects built up too -- fluid retention, aching joints and muscles, tender teeth (!)
BrentW
in
Care Community
2 years ago
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Xtandi dilemma
I had a good run on
enzalutamide
(Xtandi)—almost 3 years. Over those years, I managed to squirrel away several bottles of the stuff. Now I don't know what to do with them. I hate to see them go to waste.
I had a good run on
enzalutamide
(Xtandi)—almost 3 years. Over those years, I managed to squirrel away several bottles of the stuff. Now I don't know what to do with them. I hate to see them go to waste.
Escudilla
in
Advanced Prostate Cancer
2 years ago
Dutasteride and Apalutamide
Is there any data available on what percentage of patients become castrate resistant after long term Lupron + Apalutamide/Aberaterone//
Enzalutamide
/Darolutamide? Can triplet therapy be started after long term Lupron and Apalutamide + radiation to prostate? Thanks
Is there any data available on what percentage of patients become castrate resistant after long term Lupron + Apalutamide/Aberaterone//
Enzalutamide
/Darolutamide? Can triplet therapy be started after long term Lupron and Apalutamide + radiation to prostate? Thanks
Squirrel71
in
Advanced Prostate Cancer
2 years ago
Should Early Use of Chemotherapy Be Avoided in the Treatment of Metastatic Prostate Cancer?
In the prospective randomized crossover trial to assess the optimal sequencing of
enzalutamide
and abiraterone acetate, time to prostate-specific antigen (PSA) progression of second-line
enzalutamide
and abiraterone acetate was 3.5 and 1.7 months (4), respectively, which was consistent with the results
In the prospective randomized crossover trial to assess the optimal sequencing of
enzalutamide
and abiraterone acetate, time to prostate-specific antigen (PSA) progression of second-line
enzalutamide
and abiraterone acetate was 3.5 and 1.7 months (4), respectively, which was consistent with the results
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Radiation again or Chemo
In the last 4 years, since failing
Enzalutamide
I’ve been successfully zapping Mets. In all cases, after radiation my PSA drops from about 20 to 3 slowly over a six month period. PET scans show only 2 Mets at a time. I’ve now had 6 treatments over the past 4 years, EBRT 60gy 30 days.
In the last 4 years, since failing
Enzalutamide
I’ve been successfully zapping Mets. In all cases, after radiation my PSA drops from about 20 to 3 slowly over a six month period. PET scans show only 2 Mets at a time. I’ve now had 6 treatments over the past 4 years, EBRT 60gy 30 days.
Ausi
in
Advanced Prostate Cancer
2 years ago
Small molecule, big potential for treating prostate cancer
The next line of defense relies on drugs such as abiraterone or
enzalutamide
, which block testosterone and related androgens from binding to androgen receptors.
The next line of defense relies on drugs such as abiraterone or
enzalutamide
, which block testosterone and related androgens from binding to androgen receptors.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Recent Cardio Experience
Zeroing in on
Enzalutamide
didn’t seem very scientific/logical. I refused to make any decisions until i had spoken to my oncologist. Thankfully my oncologist concurred & we have decided to continue with the
Enzalutamide
.
Zeroing in on
Enzalutamide
didn’t seem very scientific/logical. I refused to make any decisions until i had spoken to my oncologist. Thankfully my oncologist concurred & we have decided to continue with the
Enzalutamide
.
PSA680
in
Advanced Prostate Cancer
2 years ago
PSA, Blood Workup 2 months after 2nd cycle of Lu177 (with Enzalutamide)
and also what about
enzalutamide
?
and also what about
enzalutamide
?
pka21
in
Advanced Prostate Cancer
2 years ago
More information on Lu PSMA treatment failure
There seems to be anecdotal evidence that combining
enzalutamide
with Lu PSMA yields better benefit, but the sample size is small.
There seems to be anecdotal evidence that combining
enzalutamide
with Lu PSMA yields better benefit, but the sample size is small.
Javelin18
in
Advanced Prostate Cancer
2 years ago
PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Among them, 12 patients received ARV-110 combined with
enzalutamide
(ENZ)/abiraterone (ABI), and 14 patients received prior chemotherapy.
Among them, 12 patients received ARV-110 combined with
enzalutamide
(ENZ)/abiraterone (ABI), and 14 patients received prior chemotherapy.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Salmon Protein Hydrolysate
Bicalutamide [8], and more modern ARIs such as
enzalutamide
, darolutamide, and others, have been implemented in clinical use [9].
Bicalutamide [8], and more modern ARIs such as
enzalutamide
, darolutamide, and others, have been implemented in clinical use [9].
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Latest from BATman Denmeade
Currently, we are conducting the “Sequential Testosterone and
Enzalutamide
Prevents Unfavorable Progression (STEP-UP) trial (NCT04363164) at Johns Hopkins and several other sites around the United States.
Currently, we are conducting the “Sequential Testosterone and
Enzalutamide
Prevents Unfavorable Progression (STEP-UP) trial (NCT04363164) at Johns Hopkins and several other sites around the United States.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
New BAT article
Most people get some benefit especially in reactivating previously failed antiandrogens such as
enzalutamide
. Something else the article did not mention: it does not work so well with abiraterone. In my case I reasoned that the easiest, cheapest way to find out if it works for me was just do it.
Most people get some benefit especially in reactivating previously failed antiandrogens such as
enzalutamide
. Something else the article did not mention: it does not work so well with abiraterone. In my case I reasoned that the easiest, cheapest way to find out if it works for me was just do it.
kaptank
in
Advanced Prostate Cancer
2 years ago
Second hormone therapy drug- decision needed-any views?
My Lu-177 onco would prefer me to start
Enzalutamide
(Xanti) instead to avoid prednisolone. My understanding is my private healthcare cover will pay for either- any advice here as my London onco prefers Abi!
My Lu-177 onco would prefer me to start
Enzalutamide
(Xanti) instead to avoid prednisolone. My understanding is my private healthcare cover will pay for either- any advice here as my London onco prefers Abi!
Brysonal
in
Advanced Prostate Cancer
2 years ago
Cardiotoxicity of Abiraterone and Enzalutamide in Metastatic Castration-Resistant Prostate Cancer
I don't recall this being posted: "... the abiraterone acetate group was at greater risk of cardiovascular-related hospitalization compared to the
enzalutamide
group (hazard ratio (HR) 1.82 ...).
I don't recall this being posted: "... the abiraterone acetate group was at greater risk of cardiovascular-related hospitalization compared to the
enzalutamide
group (hazard ratio (HR) 1.82 ...).
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Erleada vs. Xtandi
https://www.onclive.com/view/apalutamide-outperforms-
enzalutamide
-in-mcspc
https://www.onclive.com/view/apalutamide-outperforms-
enzalutamide
-in-mcspc
Hidden
in
Advanced Prostate Cancer
2 years ago
Effect of Covid on 2020 UK PCa stats.
Treatment patterns shifted towards those that limit the risk of Covid-19 exposure including increased use of transperineal biopsy, hypofractionated radiation, and
enzalutamide
.
Treatment patterns shifted towards those that limit the risk of Covid-19 exposure including increased use of transperineal biopsy, hypofractionated radiation, and
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
2021 Top Story in Advanced Prostate Cancer? ....
Interestingly, 77.8% of patients who received BAT followed by
enzalutamide
had a PSA50 response compared with 21.3% among those who received BAT after
enzalutamide
.
Interestingly, 77.8% of patients who received BAT followed by
enzalutamide
had a PSA50 response compared with 21.3% among those who received BAT after
enzalutamide
.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
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