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Cobimetinib
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any info about using cobimetinib, an IL-6 inhibitor, for PMR?
I've been reading the posts on this forum about Actemra (tocilizumab) and suppression of IL-6, the cytokine causing the negative symptoms of PMR. Searching the web led me to a scientific conjecture from 2018 that combimetinib may be useful for treating PMR. Has anyone heard anything further about
I've been reading the posts on this forum about Actemra (tocilizumab) and suppression of IL-6, the cytokine causing the negative symptoms of PMR. Searching the web led me to a scientific conjecture from 2018 that combimetinib may be useful for treating PMR. Has anyone heard anything further about
benhemp
in
PMRGCAuk
4 years ago
Update on insanity
Atezolizumab - Vemurafinib -
Cobimetinib
. Ryan did not fair well on a dual therapy, so I’m not sure if that will be the course of action. Definitely has to be discussed. Once the bowel heals and functions correctly he will be able to eat without restrictions and go back to normal life.
Atezolizumab - Vemurafinib -
Cobimetinib
. Ryan did not fair well on a dual therapy, so I’m not sure if that will be the course of action. Definitely has to be discussed. Once the bowel heals and functions correctly he will be able to eat without restrictions and go back to normal life.
kellyOd
in
Melanoma Caregivers
4 years ago
BOLO: New melanoma trial coming from China
IN10018 will be tested as a monotherapy and in combination with Roche's MEK inhibitor Cotellic (
cobimetinib
), which was approved to treat melanoma in 2015.
IN10018 will be tested as a monotherapy and in combination with Roche's MEK inhibitor Cotellic (
cobimetinib
), which was approved to treat melanoma in 2015.
missyrand
Ambassador
in
Melanoma Caregivers
4 years ago
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BRAF/MEK combo raises risk of cardiovascular adverse events compared to BRAF monotherapy only
Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors -- trametinib,
cobimetinib
, and binimetinib.
Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors -- trametinib,
cobimetinib
, and binimetinib.
missyrand
Ambassador
in
Melanoma Caregivers
5 years ago
Recurrence metastatic brain, bone and skin cancer need info on drug Cotellic AKA Cpbemetinib
Her doctor has started her on 20 mg of a drug called
Cobimetinib
also known as Cotellic. Her doctor wants to add another chemo drug to this one. My sister in will give me that additional information tonight.
Her doctor has started her on 20 mg of a drug called
Cobimetinib
also known as Cotellic. Her doctor wants to add another chemo drug to this one. My sister in will give me that additional information tonight.
RLN-overcomer
in
SHARE Breast Cancer Support
6 years ago
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