Experiences with

Cobimetinib

I've been reading the posts on this forum about Actemra (tocilizumab) and suppression of IL-6, the cytokine causing the negative symptoms of PMR. Searching the web led me to a scientific conjecture from 2018 that combimetinib may be useful for treating PMR. Has anyone heard anything further about

Atezolizumab - Vemurafinib - Cobimetinib. Ryan did not fair well on a dual therapy, so I’m not sure if that will be the course of action. Definitely has to be discussed. Once the bowel heals and functions correctly he will be able to eat without restrictions and go back to normal life.

IN10018 will be tested as a monotherapy and in combination with Roche's MEK inhibitor Cotellic (cobimetinib), which was approved to treat melanoma in 2015.

Three BRAF inhibitors -- dabrafenib, vemurafenib, and encorafenib -- are now approved by the FDA and the European Medicines Agency, as are three MEK inhibitors -- trametinib, cobimetinib, and binimetinib.

Her doctor has started her on 20 mg of a drug called Cobimetinib also known as Cotellic. Her doctor wants to add another chemo drug to this one. My sister in will give me that additional information tonight.