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Anyone taking Avodart (Dutasteride) as your only form of ADT?
Just curious as to whether any of you have been able to control your PSA after recurrence? Since dutasteride is an inhibitor of all three 5a-reductase isoforms, it appears to be an effective suppressor of DHT which is a considerably more potent androgen than the testosterone it is derived from. After
Just curious as to whether any of you have been able to control your PSA after recurrence? Since dutasteride is an inhibitor of all three 5a-reductase isoforms, it appears to be an effective suppressor of DHT which is a considerably more potent androgen than the testosterone it is derived from. After
E2-Guy
in
Advanced Prostate Cancer
4 years ago
After Zytiga & Extandi....?
Zytiga and
Avodart
.
Zytiga and
Avodart
.
4luvofrob
in
Advanced Prostate Cancer
4 years ago
PCa patients can benefit from 5-alpha-reductase Inhibitors.
I will continue to use
Avodart
. I view it as a 'safety play'. -Patrick [1] https://pubmed.ncbi.nlm.nih.gov/32547884/ PeerJ . 2020 Jun 1;8:e9282. doi: 10.7717/peerj.9282. eCollection 2020.
I will continue to use
Avodart
. I view it as a 'safety play'. -Patrick [1] https://pubmed.ncbi.nlm.nih.gov/32547884/ PeerJ . 2020 Jun 1;8:e9282. doi: 10.7717/peerj.9282. eCollection 2020.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
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Prednisone Caution
I also continued Lupron and
Avodart
. I also have vision/eye issues including Macular Degeneration and I have regular eye injections, and less not forget heart problems.
I also continued Lupron and
Avodart
. I also have vision/eye issues including Macular Degeneration and I have regular eye injections, and less not forget heart problems.
middlejoel
in
Advanced Prostate Cancer
4 years ago
what if chemo only brings down psa to 5.8 what is next
My husband was diagnosed in 2011, gleason 8, psa 22, many years of treatment, IMRT, zytiga, Lupron/
Avodart
. Treated with Dr. Snuffy Myers until his retirement. Psa has never been to 0. All scans stable, cancer in lymph nodes, no bone involvement.
My husband was diagnosed in 2011, gleason 8, psa 22, many years of treatment, IMRT, zytiga, Lupron/
Avodart
. Treated with Dr. Snuffy Myers until his retirement. Psa has never been to 0. All scans stable, cancer in lymph nodes, no bone involvement.
Judymin
in
Advanced Prostate Cancer
4 years ago
5 alpha reductase in inhibitors
There are many on this forum that take
Avodart
to reduce DHT levels. I perused the NCCN Guidelines Version 1.2020 - Prostate Cancer and searched Pubmed but did not find any guidance or reports that would support using an 5 alpha reductase inhibitor.
There are many on this forum that take
Avodart
to reduce DHT levels. I perused the NCCN Guidelines Version 1.2020 - Prostate Cancer and searched Pubmed but did not find any guidance or reports that would support using an 5 alpha reductase inhibitor.
PhilipSZacarias
in
Advanced Prostate Cancer
4 years ago
TMPRSS2 & COVID-19
. & men on
Avodart
may be protected from the "alternative pathway". -Patrick [1] https://en.wikipedia.org/wiki/TMPRSS2 [2] https://prost8blog.com/2020/03/29/covid-19-adt-and-prostate-cancer/ [3] https://pubmed.ncbi.nlm.nih.gov/29773553/?
. & men on
Avodart
may be protected from the "alternative pathway". -Patrick [1] https://en.wikipedia.org/wiki/TMPRSS2 [2] https://prost8blog.com/2020/03/29/covid-19-adt-and-prostate-cancer/ [3] https://pubmed.ncbi.nlm.nih.gov/29773553/?
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Association Between Dihydrotestosterone and Long-Term Risk for PCa Mortality
At that point, I started to use
Avodart
to inhibit 5alpha-reductase.
At that point, I started to use
Avodart
to inhibit 5alpha-reductase.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Nuclear Receptor ERRα Contributes to Castration-Resistant Growth of Prostate Cancer via Its Regulation of Intratumoral Androgen Biosynthesis
(The reason some use a statin &/or
Avodart
.) Note. ERRα is: estrogen-related receptor alpha.
(The reason some use a statin &/or
Avodart
.) Note. ERRα is: estrogen-related receptor alpha.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Go to MO or not?
Been on Lupron, Casodex,
Avodart
forever. MO Appt tomorrow here in NJ. No discernible Covid 19 symptoms; T=97.5-98.5F! Do I go or postpone? (84, GS6, T2B in 1997, Pd+XBRT,recurred in 2001. Current psa on hormones: 0.4!; hi bp, triple bypass in '17).
Been on Lupron, Casodex,
Avodart
forever. MO Appt tomorrow here in NJ. No discernible Covid 19 symptoms; T=97.5-98.5F! Do I go or postpone? (84, GS6, T2B in 1997, Pd+XBRT,recurred in 2001. Current psa on hormones: 0.4!; hi bp, triple bypass in '17).
herb1
in
Advanced Prostate Cancer
5 years ago
Good times in a crazy world
I had a talk with my MO about
Avodart
, and he doesn't have a problem with me taking it, and I will start doing this shortly. He is not too keen on IADt( The reason I want to start
Avodart
) because of my high Gleason score(9), but is willing to consider it at a later stage in my treatment.
I had a talk with my MO about
Avodart
, and he doesn't have a problem with me taking it, and I will start doing this shortly. He is not too keen on IADt( The reason I want to start
Avodart
) because of my high Gleason score(9), but is willing to consider it at a later stage in my treatment.
Arnie1970
in
Advanced Prostate Cancer
5 years ago
Health Risks Associated With Long-Term Finasteride and Dutasteride Use: It's Time to Sound the Alarm
Incidentally,
Avodart
has a long half-life. Taking a vacation from the drug isn't so easy. -Patrick [1] https://pubmed.ncbi.nlm.nih.gov/32202088/?
Incidentally,
Avodart
has a long half-life. Taking a vacation from the drug isn't so easy. -Patrick [1] https://pubmed.ncbi.nlm.nih.gov/32202088/?
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Need advice after failed RP
If
Avodart
works for me that won't happen anyway (hopefully). Recently I see evidence that high testosterone treatments are being suggested but this is completely opposite to conventional treatment, should I dismiss this immediately?
If
Avodart
works for me that won't happen anyway (hopefully). Recently I see evidence that high testosterone treatments are being suggested but this is completely opposite to conventional treatment, should I dismiss this immediately?
Afterglow
in
Advanced Prostate Cancer
5 years ago
For PCx - Should I get Doxycycline and Avodart prescripts from oncologist or dermatologist?
Should I get Doxycycline and
Avodart
prescripts from a med oncologist or dermatologist, if my intended benefits are to slow the prostate cancer growth?
Should I get Doxycycline and
Avodart
prescripts from a med oncologist or dermatologist, if my intended benefits are to slow the prostate cancer growth?
GeorgeGlass
in
Advanced Prostate Cancer
5 years ago
LAMOTRIGINE ER
Currently I am on Lupron +
Avodart
+ Zytiga + Prednisone + Metformin, Anyone here on this forum familiar with Lamotrigine? It's usually used for seizures. I have been tested for Alzheimer's and I Don't have that disease. middlejoe
Currently I am on Lupron +
Avodart
+ Zytiga + Prednisone + Metformin, Anyone here on this forum familiar with Lamotrigine? It's usually used for seizures. I have been tested for Alzheimer's and I Don't have that disease. middlejoe
middlejoel
in
Advanced Prostate Cancer
5 years ago
TRT and measurable uPSA after RRP
https://imgur.com/a/nibLuxB I stopped the
Avodart
after 3 weeks as I became concerned that I could be masking a BCR. I also discovered
Avodart
can have effect up to 4-6 months after stopping it.
https://imgur.com/a/nibLuxB I stopped the
Avodart
after 3 weeks as I became concerned that I could be masking a BCR. I also discovered
Avodart
can have effect up to 4-6 months after stopping it.
LowT
in
Advanced Prostate Cancer
5 years ago
DHT / Avodart
There have been some negative posts regarding the potential benefit of Dutasteride [
Avodart
] against PCa. Dr Myers used
Avodart
in men on ADT who nonetheless produced significant levels of dihydrotestosterone [DHT]. (The true target of ADT is DHT - not testosterone [T].)
There have been some negative posts regarding the potential benefit of Dutasteride [
Avodart
] against PCa. Dr Myers used
Avodart
in men on ADT who nonetheless produced significant levels of dihydrotestosterone [DHT]. (The true target of ADT is DHT - not testosterone [T].)
pjoshea13
in
Advanced Prostate Cancer
5 years ago
Is Anyone Using Testosterone Therapy?
I take
Avodart
daily and 0.5 mg Arimidex 3x per week. I am considering supplemental Testosterone Therapy (TTh). Dr. Morgentaler thinks I am a candidate for continuous TTh. Is anyone doing TTh?
I take
Avodart
daily and 0.5 mg Arimidex 3x per week. I am considering supplemental Testosterone Therapy (TTh). Dr. Morgentaler thinks I am a candidate for continuous TTh. Is anyone doing TTh?
davidhike
in
Advanced Prostate Cancer
5 years ago
Avodart when off ADT a mistake?
If one is trying to prevent prostate cancer cells from becoming insensitive to ADT, then is it wise to continue dutasteride while on the off cycle? If per Snuffy most of the support for PC cells comes from DHT not T, then just as stopping T reduces the DHT, is not dutasteride acting in a similar way
If one is trying to prevent prostate cancer cells from becoming insensitive to ADT, then is it wise to continue dutasteride while on the off cycle? If per Snuffy most of the support for PC cells comes from DHT not T, then just as stopping T reduces the DHT, is not dutasteride acting in a similar way
cigafred
in
Advanced Prostate Cancer
5 years ago
What to expect from chemo, if doesn't work what is next?
Snuffy Myers, had
Avodart
, Firmagon, later on to Zytiga which worked for almost 3 years. Now Snuffy is retired, see a new oncologist, scans show some slight elevation in pelvic lymph nodes, bone scan negative but psa now up to 30!!!.
Snuffy Myers, had
Avodart
, Firmagon, later on to Zytiga which worked for almost 3 years. Now Snuffy is retired, see a new oncologist, scans show some slight elevation in pelvic lymph nodes, bone scan negative but psa now up to 30!!!.
Judymin
in
Advanced Prostate Cancer
5 years ago
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