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Abiraterone
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Re-treatment with radium-223.
Concomitant agents were allowed at investigator discretion, excluding chemotherapy and initiation of new
abiraterone
or enzalutamide.
Concomitant agents were allowed at investigator discretion, excluding chemotherapy and initiation of new
abiraterone
or enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
STAMPEDE Trial: Adding Abiraterone Acetate or Docetaxel Plus Prednisone to ADT.
Failure–free and progression-free survival clearly favoured SOC+
abiraterone
+prednisone, and with less certainty, metastasis-free survival favoured SOC+
abiraterone
+prednisone.
Failure–free and progression-free survival clearly favoured SOC+
abiraterone
+prednisone, and with less certainty, metastasis-free survival favoured SOC+
abiraterone
+prednisone.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
New AR-V7 Test. German; simpler; cheaper(?).
Moreover, it can also determine whether or not the tumor is resistant to treatment with
abiraterone
and enzalutamide.
Moreover, it can also determine whether or not the tumor is resistant to treatment with
abiraterone
and enzalutamide.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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Advanced Metastatic Prostate Cancer Survivor
PSA after 7 months of treatment on the stampede trials program using
Abiraterone
/Prostap is less than 0.1ng/ml. Currently, my cancer is managed very well indeed...
PSA after 7 months of treatment on the stampede trials program using
Abiraterone
/Prostap is less than 0.1ng/ml. Currently, my cancer is managed very well indeed...
alsam
in
Advanced Prostate Cancer
7 years ago
Dad's first Oncology appointment
Also I asked my Dad to raise the possibility of early use of
abiraterone
/zytiga as we have all seen the recent groundbreaking results from the STAMPEDE trial about the benefits. Apparently the oncologist said that NICE had not granted a licence for
abiraterone
yet and so this wasn't possible.
Also I asked my Dad to raise the possibility of early use of
abiraterone
/zytiga as we have all seen the recent groundbreaking results from the STAMPEDE trial about the benefits. Apparently the oncologist said that NICE had not granted a licence for
abiraterone
yet and so this wasn't possible.
Jlcwonderboy
in
Advanced Prostate Cancer
7 years ago
Olaparib & Durvalumab ... ASCO 2017
All were treated with enzalutamide (35%),
abiraterone
(6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
All were treated with enzalutamide (35%),
abiraterone
(6%) or both (59%). Most were ECOG status 0-1. 63% had bony and visceral metastatic disease.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins + CRPC
"We assessed the effects of statin use in patients with advanced prostate cancer receiving
abiraterone
. Patients treated with a statin plus
abiraterone
appeared to live longer than those treated with
abiraterone
only.
"We assessed the effects of statin use in patients with advanced prostate cancer receiving
abiraterone
. Patients treated with a statin plus
abiraterone
appeared to live longer than those treated with
abiraterone
only.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
AR-V7 Tests - Video
So, the usefulness of the test really becomes important after
abiraterone
or enzalutamide particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
So, the usefulness of the test really becomes important after
abiraterone
or enzalutamide particularly. The second AR-V7 test, which was developed at Johns Hopkins by Dr. Luo’s lab, is an RNA-based expression.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Zytiga + Statins in CRPC
KEYWORDS: SLCO transport;
abiraterone
acetate; duration; prostate cancer; statins PMID: 28762529 DOI: 10.1002/pros.23390
KEYWORDS: SLCO transport;
abiraterone
acetate; duration; prostate cancer; statins PMID: 28762529 DOI: 10.1002/pros.23390
pjoshea13
in
Advanced Prostate Cancer
7 years ago
First line therapy changes
On June 3, 2017, it printed the following trial conclusion: “Among men with locally advanced or metastatic prostate cancer, ADT plus
abiraterone
and prednisolone was associated with significantly higher rates of overall and failure-free survival than ADT alone.
On June 3, 2017, it printed the following trial conclusion: “Among men with locally advanced or metastatic prostate cancer, ADT plus
abiraterone
and prednisolone was associated with significantly higher rates of overall and failure-free survival than ADT alone.
leswell
in
Advanced Prostate Cancer
7 years ago
free Testosterone [fT] & survival.
in 47% of patients in the
abiraterone
arm, while none of the patients continuing regular androgen deprivation exhibited serum testosterone levels below the detection threshold.
in 47% of patients in the
abiraterone
arm, while none of the patients continuing regular androgen deprivation exhibited serum testosterone levels below the detection threshold.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
Quercetin & AR-V7.
The splice variants AR-V7 and Arv567es have been implicated in the resistance to not only enzalutamide, but also to
abiraterone
and other conventional therapeutics such as taxanes.
The splice variants AR-V7 and Arv567es have been implicated in the resistance to not only enzalutamide, but also to
abiraterone
and other conventional therapeutics such as taxanes.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
abiraterone
hi all a short question i started
abiraterone
+ prednisone in january 17 but after some months or years ? chemio? mha.......... by
hi all a short question i started
abiraterone
+ prednisone in january 17 but after some months or years ? chemio? mha.......... by
Sergio1
in
Advanced Prostate Cancer
7 years ago
LATITUDE - Zytiga & ADT - NEJM Paper
Rates of grade 3 hypertension and hypokalemia were higher in the
abiraterone
group.
Rates of grade 3 hypertension and hypokalemia were higher in the
abiraterone
group.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
LATITUDE - Zytiga & ADT
Median OS for the
abiraterone
acetate plus prednisone in combination with ADT arm was not reached, while the median OS for the placebo plus ADT arm was 34.7 months.
Median OS for the
abiraterone
acetate plus prednisone in combination with ADT arm was not reached, while the median OS for the placebo plus ADT arm was 34.7 months.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
abiraterone & nausea
hi i 'm from italy and i'm 66 old I use abiraterome since January, 4 pills a day, and unlucky I suffer from a slight nausea. Can anyone give me quache advice? Thanks Sergio
hi i 'm from italy and i'm 66 old I use abiraterome since January, 4 pills a day, and unlucky I suffer from a slight nausea. Can anyone give me quache advice? Thanks Sergio
Sergio1
in
Advanced Prostate Cancer
7 years ago
Help - Zytiga (Abiraterone) with Lupron & anything else you would recommend.
Hi All, I am 56 years old, have been on board with you since April. I was dx in February 2017 with pca, GS 8, PSA 8.8, spreading to left seminal vesicle and two bone mets, one in right pelvis and one in right femur. I have been on Lupron with Casodex (50 mgs daily) and feel a million times better
Hi All, I am 56 years old, have been on board with you since April. I was dx in February 2017 with pca, GS 8, PSA 8.8, spreading to left seminal vesicle and two bone mets, one in right pelvis and one in right femur. I have been on Lupron with Casodex (50 mgs daily) and feel a million times better
Stickingaround1
in
Advanced Prostate Cancer
7 years ago
Taking Abiraterone with food
I have been taking for the last six months or so, 3
abiraterone
with my evening meal and then one at bed time. This certainly dropped my PSA initially, but now it is rising again. Has anyone any experience of taking one with each meal throughout the day?
I have been taking for the last six months or so, 3
abiraterone
with my evening meal and then one at bed time. This certainly dropped my PSA initially, but now it is rising again. Has anyone any experience of taking one with each meal throughout the day?
NiallMcC
in
Advanced Prostate Cancer
7 years ago
CRPC & Prednisolone or Dexamethasone. Neutrophil to Lymphocyte Ratio [NLR].
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior
abiraterone
or enzalutamide therapy."
A 2015 paper [2] details a Phase II study "among chemotherapy naïve CRPC patients who had not received prior
abiraterone
or enzalutamide therapy."
pjoshea13
in
Advanced Prostate Cancer
7 years ago
STAMPEDE - Zytiga at ADT initiation.
Abiraterone
can clearly help many more prostate cancer patients than was first thought.
Abiraterone
can clearly help many more prostate cancer patients than was first thought.
pjoshea13
in
Advanced Prostate Cancer
7 years ago
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