Hi I have been on Sulfasalazine for o... - The Australian Sj...

The Australian Sjögren's Syndrome Association

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Hi I have been on Sulfasalazine for over 6 mths now and my symptoms have improved so much, most of my markers are normal except crp, why?

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Why would my crp still be increasing any advise please on how to bring it down. What could be causing it to be so high

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Jacquiwitt
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Hi there. Are you taking Sulfasalazine for primary Sjögren’s or for RA I wonder? And when you say your CRP is so high and yet your symptoms are improving - which symptoms are these and what number is your CRP? I ask because mine is usually high apart from when I’ve been on steroids. I’m on Mycophenolate now and it’s still raised as is PV/ ESR.

A Sjögren’s specialist says that raised CRP is not normally associated with Sjögren’s - more commonly associated with RA. I have primary Sjögren’s. I don’t hold it against Mycophenolate because some other bloods have improved as have joint symptoms - but it never came down fully when I was on Sulfasalazine (only lasted 3 weeks before anaphylaxis!), Hydroxichloraquine or Methotrexate.

Only steroids take my CRP down to normal.