How Gabapentin Differs From Pregabalin

[rls-ottawa]

pharmacytimes.com/view/how-...

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[ChrisColumbus]

Do these 'Final Thoughts' summarise the key points, or have I missed something?

"Though pregabalin and gabapentin have somewhat similar pharmacokinetic and pharmacodynamic profiles, there are clearly significant differences.

Overall, pregabalin has more predictable pharmacokinetics, and it also shows a stronger binding affinity to its target receptor, increased potency, and a steeper dose-response curve in neuropathic pain that does not plateau over recommended dosing levels.

A few studies have found that pregabalin has fewer side effects and may be more efficacious for neuropathic pain than gabapentin. Several studies reviewing conversion of gabapentin to pregabalin predict that a rough ratio for conversion is about 6:1 gabapentin to pregabalin. In addition, a direct switch from gabapentin to pregabalin seems to be well tolerated, making the conversion simple.

Clinicians should note that pregabalin has various pharmacokinetic and pharmacodynamic advantages over gabapentin, and a conversion between the 2 medications is often well tolerated."

[ChrisColumbus in reply to ChrisColumbus]

The above dates from 2015: the link from that to the 2017 report on appropriate gabapentin dosing for neuropathic pain isn't working, so here's that:

pharmacytimes.com/view/appr...