For Eryl

8 years later and I still agree with this post. I think Eryl will too:

Brett85

8 years ago

so some people with renal failure will notice the drops in iron and some won't notice the drops in iron. Your big point is that while we are sleeping, our iron availability dropsfor all people but only some will have symptoms of that happening.

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8 years ago

Yes and no, now that you put it that way. I believe there is a genetic variable with an environmental trigger. It might not be so much a "sensitivity" as an over-reaction to infections and inflammation in our bodies. We REALLY withhold iron in the face of infection and inflammation. We produce more hepcidin than EVIAN has water. Add to that the natural drop of serum iron at night and we get RLS. I bet if we were free of infection and inflammation and disease there would be no symptoms of RLS. There would just be this really defensive gene ready to strike at a moment's notice. If that notice never comes then the gene is silent and so are our legs.