Omeprozole

[cicek]

Hi again. Hope everyone is having a good weekend and getting some rest. I am, as you know weaning off Roprinirole and have been given some Pregabalin by my GP which I will begin next week when I reduce to .50 mg. Not been able to sit down in the afternoon or evenings for over 3 weeks now but am getting some sleep which is helping. I obtained some Codeine 15mg from a friend, took one yesterday evening , and have to say I got some peace and actually sat down! Needless to say I will take another one this evening. Enough waffling, my question is Omeprozole. I saw a post on here (about a day ago), stating Opeprozole makes RLS worse. Is this right as I have never heard it mentioned before and I take it daily? Thanks.

[Madlegs1]

Most "prazoles" make rls worse.You would need to Google for alternatives.

Or check with Dr/ pharmacist?

Good luck.

Depending on the dose, it could be a major source of your RLS troubles.

This is why we need to know your full medications history when you come on here.😎

[cicek in reply to Madlegs1]

Thanks. I have been taking it for years but certainly not before my RLS began. I have had years of peace from Roprinirole even while taking Omeprozole. I just saw a post on here saying it was a trigger so needed to ask. I don't take it for acid reflux, I was given it as a stomach protection because I am on a lot of drugs. Initially the main culprit for taking it was Naproxen but I don't take that any longer. Perhaps, as you suggest, I should as the pharmacist. Thank you for your continued good advice.

[Hidden]

I take a omeprazole every morning and it has no affect on my RLS.

[cicek in reply to Hidden]

Thanks Elisse. I have been taking it for years, certainly all the time during my RLS years.

[Elffindoe]

Hi,

I don't really know why you're delaying with the pregabalin you could start now. However, if you're only down to 0.5mg, it may not make a lot of difference.

Proton pump (PPI) and H2 inhibitor antacids are generally recognised as not advisable for RLS.

They may not necessarily affect everybody to the same degree and tbeir effect may not be immediate.

The explanation for them affecting RLS is that they can prevent iron absorption. Depending on your current iron levels, this may or may not be am immediate problem..

I suggest you try the omeprazole (a PPI), and if you have benefit without affecting RLS, that's OK. I have recently taken it a month without ill effect, but then stopped it,

I do suggest you have blood tests for serum iron, transferrin saturation and ferritin. Then follow the reccommendations for iron therapy depending on the results. These apply to everybody with RLS, PPI or not. Have the tests repeated every 6 months.

See under "General Considerations" in this link.

mayoclinicproceedings.org/a...

[cicek in reply to Elffindoe]

Hi. I'll start my 0.5mg tomorrow. I have now had my Pregabalin prescription made up and will begin, I think, when I reach 0.25mg. I understand you say it probably won't work while I am still on Roprinirole but hopefully by that stage, two weeks on the low dose and two weeks following, the Pregabalin should be well into my system. I do already take Omeprazole and have been doing for years. I am also having a Ferritin blood test on 29th November. It was 90 in 2020. I think I mentioned before that due to the fact I have Polcythemia, my GP suggested I didn't take any extra iron until he had taken advice from the Haematology Department. They take my blood every 8 weeks to see whether I need an venesection or not. Again thanks for all your helpful advice on here. I for one (certainly at the moment and in the past) couldn't get by without it especially at the bad times like now x

[Hidden in reply to Elffindoe]

After reading your comment i will ask for blood tests as per your advice i haven’t had one for my ferritin for a while as a Primary RLS sufferer not sure having a higher ferritin level would make any difference to my RLS. It’s the same now as it was before i started the omeprazole the highest my ferritin level has been was 118 I had bloods done recently as i was being investigated for something else so they were looking for other results from not ferritin level

[Elffindoe in reply to Hidden]

I believe ferritin levels are as much an issue in Primary RLS, in fact more so, as Brain Iron Deficiency is a fundamental cause of primary RLS.

This is due to the poor transportation of iron across the blood brain barrier which people who do not have primary RLS do not suffer from.

People with primary RLS need to have higher ferritin levels than nom-primary/non-RLS in order to have the same iron levels. Around 200.

[AlexMac83]

I know from personal experience I had some acid reflux issues a couple of years ago, my ferritin level pre medication was 129, after 16 months of mainly daily Omeprazole use I started with various leg pain / problems / muscle twitching etc, I was left on Omeprazole for months with no check ups etc

Bloods done again in July this year & ferritin was now 66 , so basically halved.

Few docs spoke to not that interested in that fact but I'm hoping it's why I'm having leg problems as docs just given up now after several appointments and just got to live with the twitching/pain as they not concerned it's something bad!

I'm off the Omeprazole now & trying to build my ferritin levels up, but this can be a long process unfortunately

Good luck

[Elffindoe in reply to AlexMac83]

Have you been diagnosed with RLS?

What treatment have you been advised or what treatment are you taking?

[AlexMac83 in reply to Elffindoe]

Nope, had say 8 docs appointments from July-Oct & eventually a doc has referred me to Neurology but reckon be waiting a while & only because it is really starting to worry me

Docs happy nothing sinister but easy to Dr Google & come to worst case, eg MND......I'm hoping it's either low Iron as shown in my bloods or side effects of Covid jab as started having my leg issues couple weeks after 2nd jab and after first had 2 nights of really bad leg pain, but obviously once I mention that people look at you oddly!

Main symptoms are twitching in calves mainly and other odd places, keep straining leg muscles / ligaments and general pain in calves.

So bit in limbo at the moment with it all

[Elffindoe in reply to AlexMac83]

I'm sorry to hear this and can appreciate you getting worried.

As you may appreciate Dr Google is not the best Dr as in effect, you are self-diagnosing. Obviously, I'm not in any position to say you have MND or not. I'd say unlikely, since yo\\>÷€€u make no mention of weakness anywhere.

Also, 8 docs will at some time have managed to do a neurological exam at some time?

From your symptoms, neurology sounds in the right direction.

It's always awful to know there is something wrong and not knowing what it is and what can be done to put it right. Waiting to get a diagnosis is the worst part.

Again obviously, I'm not in any position to offer any diagnosis. However can offer some thoughts about RLS.

You say you haven't been diagnosed with RLS, but since you're on this site then you may have thought of it, or it's been suggested as a possibility.

Let's look at that.

Firstly, you say your iron is low. The result you give is ferritin and this is 66.

This is not actually low! Quite normal.

More significant would be your serum iron, transferrin saturation (TSAT) and haemoglobin.

If the first two are low, then you can say you have low iron. If haemoglobin is also low then iron deficiency anaemia, (IDA).

This is significant because IDA can cause "secondary RLS".

A ferritin level of 66 is only really significant if you have "primary RLS" An inherited condition.

RLS is diagnosed by its symptoms. There are no real tests for it.

Hence it's a matter of comparing symptoms to the diagnostic criteria.

From the symptoms you describe, I wouldn't exclude these as being RLS. However, with such little detail it's impossible to say.

Twitching is notbuncommon in RLS, despite it not being in the criteria.

The same applies to pain.

The principal symptom of RLS is the urge to move. That is a feeling that you just need to move. Sometimes this can result in involuntary movements.

What's important however is that these symotoms -

Usually occur when you are sutting or lying down

Are usually relieved by moving

Only occur at night or are worse at night.

If these apply to you, then I suspect you may have RLS.

If not, then at least that can be excluded.

I hope you find out an answer soon.

[Bluebboat]

You have possibly tried this already but I thought I should mention that I completely resolved acid reflux and all digestive issues but cutting right down on gluten and dairy. I try to follow Dr Sarah Myhill on diet I think she is brilliant. Lots of chronic conditions simply disappear when you follow her paleo ketogenic diet.

[cicek in reply to Bluebboat]

Thanks for that info. I don't actually get acid reflux but take it as a stomach protection. I know what you mean about diet though!

[Mum007]

I have tried ALL the ppi drugs plus over the counter gaviscon and they all give me restless legs after taking them for a few days. I now take mastic gum and it is the most helpful thing I have tried.

[cicek in reply to Mum007]

Thank you. Just as a matter of interest, what is mastic gum?

[Mum007]

Mastic gum is a resin sourced from the mastic tree (Pistacia lentiscus) in Greece. It is traditionally used as chewing gum to freshen breath and aid in digestion. Practitioners of alternative medicine have long touted mastic gum as a natural remedy for indigestion, acid reflux, peptic ulcers, inflammatory bowel disease (IBD), respiratory problems, gum disease, and various bacterial or fungal infections. The aromatic oils in mastic gum—the flavor of which is best described as a mix between pine and eucalyptus—can also help fight bad breath.

[cicek in reply to Mum007]

Thank you that sounds very interesting.

[marsha2306]

I just started taking it a week and a half ago. It’s definitely not making my RLS worse but it’s killing my stomach. Graphically, constipating but always feel like you have to go.

[Gmc54]

I've been taking omeprazole for about a year now. It's made no difference to my rls.