Testosterone levels and Prostate Cancer Risk - 1

[janebob99]

This plot shows the association of baseline testosterone levels with PCa aggressiveness. For example, if you have low aggressive PCA, your testosterone is likely to be Normal. But, if you have metastatic PCa, your testosterone is likely to be very Low. This shows that having normal testosterone levels is protective against prostate cancer.

Ref: spandidos-publications.com/...

[Justfor_]

Mine was in the 800 to 900 range, 99+ percentile for age, but this didn't protect me from GS=9 and pT3b.

[tarhoosier]

Your conclusion is not at all what this study shows. You confuse correlation with causation, a basic error. It is also possible, though the researchers do not state this, that higher Gleason (aggression) tumors consume more testosterone than lower grade, more "normal" prostate tumors and benign prostate tissue itself. This would lead to lower serum T for those with higher G tumors.

[janebob99 in reply to tarhoosier]

Interesting thought. More studies are needed.

[janebob99]

Good thought!

There are older papers that support your suggestion (from 2016 time frame). See papers by A. Morgentaler from Harvard.

Attached is a schematic of the Morgantaler Saturation Model. It's important to note that a T-level > 250 ng/dL still has a non-zero Prostate Cancer Growth Rate. So, high testosterone won't prevent all prostate cancer. But, higher testosterone above 250 is associated with less aggressive PCa.

Bob

Morgentaler Saturation Model