SBRT for high risk - results may be as good as brachy boost therapy, and toxicity may be lower

[Tall_Allen]

A small (n=60) pilot trial in Canada of high-risk men treated with SBRT (or SABR) reported great results. Half the men had whole pelvic radiation (+ seminal vesicles), half had prostate and seminal vesicles only, with a higher SV dose. After 5 years, biochemical failure only occurred in 15% of the men who had SBRT to the prostate+SV-only, and was ZERO among the men who received whole pelvic radiation. Pretty impressive so far.

pcnrv.blogspot.com/2017/03/...

[dentaltwin]

Thanks for this--very encouraging. The Alayed paper is behind a pay wall--do you know if the cohorts were randomly assigned?

[Tall_Allen in reply to dentaltwin]

They were actually from two different trials done consecutively. They had the same recruitment criteria.

[dentaltwin in reply to Tall_Allen]

Thanks--yes, small trial and not statistically powerful, but encouraging nonetheless. Particularly positive given the non-inferiority with pelvic radiation.

[Tall_Allen in reply to dentaltwin]

I worried about the toxicity of whole pelvic SBRT - but at least in those 30 men, it didn't seem to be an issue. It should only be done in clinical trials for now.