Why does PMR burn out eventually ?

[Daisyfield]

Does anyone know why PMR and GCA burn out eventually, when many autoimmune conditions are lifelong?

Just curious about the mechanism and wonder if the science can help shorten that process.

[Hidden]

Technically the burn out is just remission. Like other conditions it can flare.

The mechanisms are not fully understood and it's possible there are different version of PMR which complicates it's further.

Try this....

ncbi.nlm.nih.gov/pmc/articl...

[Daisyfield in reply to Hidden]

Thank you. V interesting.

[jinasc]

Until we find cause and cure, in the most difficult group of 800 registered orphan/auto-immune illnesses.

Most come when they want and go when they want and then repeat in some people. They have minds of their own.

It is our own body that decides to attack itself and that complicates everything. We might have much in common, but basically we are all different.

One example is penicillin helps lots of people, but there are people, like me, who have an allergic re-action and................

[PMRpro Ambassador]

No-one knows - it just makes it an autoimmune disease that is less worse ...

The use of tocilizumab MAY be working on the a/i part of PMR when it stops the generation of IL-6 which allows the reduction of pred and, for half, possibly even getting off pred. But it doesn't work for all - it can't do anything about other underlying mechanisms because it is so specific in what it does.

[Daisyfield in reply to PMRpro]

Thank you...seems so many factors affecting who gets it, how badly and for how long.

Good to know it can go into remission.