I have been diagnosed with Macrcytosis and alot of the symptoms are familiar to me... with whom do I discuss this? Help!

[kellymmdavis]

[nostoneunturned]

As you have macrocytosis confirmed surely your doctor knows that you should be treated in accordance with the British National Formulary as you must also have low B12 levels - presumably checked, so what are they, plus the folate and ferritin levels also?

Meantime, here is what he should be doing, straight from the doctors' "Bible".

Page 593, September 2011 edition of BNF

Hydroxocobalamin

Dose

By intramuscular injection, pernicious anaemia and other macrocytic anaemias without neurological involvement, initially 1mg 3 times a weekfor 2 weeks then 1mg every 3 months.

Pernicious anaemia and other macrocytic anaemias with neurological involvement, initially 1mg on alternate days until no further improvement then 1mg every two months.

Prophylaxis of macrocytic anaemias associated with vitamin B12 deficiency, 1mg every 2-3 months.

You have symptoms, so the second treatment seems to be applicable. Or perhaps you have a dumb doctor like mine who was contemptuous of my pleas for treatment, watched baffled as my muscles leapt and writhed spontaneously, listened to my 28 or so other symptoms then described me as having health anxiety and dismissed me from his presence - permanently! Enough to make a horse laugh - but it is not funny, really.

Please keep in touch about this because it truly is NOT funny and I am sure I can help you as I did myself, but do try for the injections first as they are best, really.

[kellymmdavis in reply to nostoneunturned]

Many thanks for your very informative response, I had a major health scare recently, which has luckily come to nothing and have, therefore, ignored the macrocytosis - will chase GP...I do find their attitudes "Holier than Thou" at times.

[Hidden]

Hi,

It depends what is the cause of the macrocytosis, it can be caused by B12 def, and or folate def, hypothyroid and other reasons, so it will need investigating...

Kind regards,

Marre.

[Hidden]

Hi Pettals,

Marcocytosis is:

"Definition

Macrocytosis means that the red blood cells are larger than normal"

See:

patient.co.uk/doctor/Macroc...

"Epidemiology[2]

•One study found that the most common cause of macrocytosis was medication (37%), followed by alcoholism (26%). Serum B12 and/or folate deficiency, bone marrow dysplasia and nonalcoholic liver disease each accounted for 6%.[3]

•The most common cause of megaloblastic anaemia is pernicious anaemia. The peak age of diagnosis is 60 years with a female to male ratio of 1.6:1. There is often a family history and it may be associated with other autoimmune disorders.

•Vitamin B12 deficiency or folic acid deficiency together account for most cases of megaloblastic anaemia.

•Vitamin B12 deficiency can be due to disease of the terminal ileum, especially Crohn's disease and other rare causes"

KInd regards,

Marre.

[sansin]

Hi nostoneunturned,

I have been given exactly same treatment B12 every other day for 2 weeks and then they have planned for every 3 months. I am low on Iron, Folate and B12 and GP has started my iron tablets and folic acid tablest and now B12 injections. They did Coelic's disease test, Intrinsic factor test and both are negative. Vitamin D result is still pending. My GP is very slow in finding the cause for this deficiencies.

What do you think could cause the B12 deficiency if there is no PA and Coelic disease?

What other tests should I ask my GP to do to find the cause?

I also have very sensitive, if I take one pint of beer I starts having rashes on my whole body and GP is not listening on this, just ignores me.

If I eat any high protein food like peanut butter or soya drinks, with in 15 minutes i starts having sever neck pain in my neck. This indicates my neurological system is not accepting high protein, what would this happen?

Please reply if you have any idea on this.